Böcker utgivna av Springer Verlag, Singapore

This book describes the authorΓÇÖs work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrroleΓÇôimidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author''s own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.This work will attract readersΓÇÖ interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the authorΓÇÖs studies and to perform similar and extended studies themselves.

This book is a collection of research articles that deal with three aspects of simulation and gaming for social design: (1) Theory and methodology, including game system theory and agent-based modeling;

This comprehensive edited book on microbial prospective discusses the innovative approaches and investigation strategies, as well as provides a broad spectrum of the cutting-edge research on the processing, properties and technological developments of microbial products and their applications.

This book constitutes the refereed post-conference proceedings of the 5th International Conference on Cognitive Systems and Signal Processing, ICCSIP 2020, held in Zhuhai, China, in December 2020. The 59 revised papers presented were carefully reviewed and selected from 120 submissions.

This book presents the cold side of the Universe illustrated by the rest-frame, far-infrared emission with Atacama Large Millimeter/submillimeter Array (ALMA).

This book constitutes the refereed post-conference proceedings of the 15th CCF Conference on Computer Supported Cooperative Work and Social Computing, ChineseCSCW 2020, held in Shenzhen, China, in November 2020.The 40 revised full papers and 15 revised short papers were carefully reviewed and selected from 137 submissions.

This book brings together strategies and innovations that educators from diverse educational contexts have conceptualized and implemented to cater to differences in academic ability, as well as in other domains such as psychosocial contexts and developmental needs.

This book gives a rigorous and up-to-date study of the various AI and machine learning algorithms for resolving environmental challenges associated with blasting. A small amount of explosive energy is only used during blasting to fracture rock in order to achieve the appropriate fragmentation, throw, and development of muck pile.

The common cavity deformity (CCD) of the inner ear is characterized by cochlea and vestibule forming a single cavity. This book describes the embryology of CCD, preoperative auditory, balance and vestibular evaluation, and electrophysiology and radiology aspect for CCD.

This book highlights a timely and accurate insight at the endeavour of the bioinformatics and genomics clinicians from industry and academia to address the societal needs. The contents of the book unearth the lacuna between the medication and treatment in the current preventive medicinal and pharmaceutical system. It contains chapters prepared by experts in life sciences along with data scientists for examining the circumstances of health care system for the next decade. It also highlights the automated processes for analyzing data in clinical trial research, specifically for drug development. Additionally, the data science solutions provided in this book help pharmaceutical companies to improve on what had historically been manual, costly and laborious process for cross-referencing research in clinical trials on drug development, while laying the groundwork for use with a full range of other drugs for the conditions ranging from tuberculosis, to diabetes, to heart attacks and many others.

This book draws on both in and out of school literacy practices with teachers and families to enhance the numeracy of early learners. It provides highly illustrative exemplars, targeted for learners up to approximately eight years of age whose home language differs from the language of instruction. It identifies the challenges faced by these learners and their families, and shares ways of building both literacy and numeracy skills for some of the vulnerable learners nationally and internationally.The book shares the outcomes and strategies for teaching mathematics to early years learners and highlights the importance of literacy practices for learners for whom the language of instruction is different from their home language. Readers will gain a practical sense of how to create contexts, classrooms and practices to scaffold these learners to build robust understandings of mathematics.

This two-volume set (CCIS 1367-1368) constitutes reviewed and selected papers from the 10th International Advanced Computing Conference, IACC 2020, held in December 2020. The 65 full papers and 2 short papers presented in two volumes were thorougly reviewed and selected from 286 submissions.

Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR.

The book is about climate resilience and environmental sustainability approaches, discussing knowledge at global level and the local challenges, presented by authors from various countries.

The book reviews globalisation by identifying causes behind the discontent it has produced in recent years. It variously engages in economics, political economy, development and policy discourses to study experiences of countries and institutions in managing and adjusting to globalisation.

This book is about the role played by microbes in their community mode in sustaining ecosystems. The descriptions given in its chapters indicate clearly that microbial communities are more effective in delivering multifaceted benefits to the soil-plant system than those offered by microbial monocultures in planktonic modes.

This book constitutes the refereed proceedings of the 6th International Conference on Soft Computing in Data Science, SCDS 2021, which was held virtually in November 2021. The 31 revised full papers presented were carefully reviewed and selected from 79 submissions. data analytics and technologies; data mining and image processing;

This book discusses the impact of climate change, land use and land cover, and socio-economic dynamics on landslides in Asian countries.

This book introduces typical inertial devices and inertial-based integrated navigation systems, gyro noise suppression, gyro temperature drift error modeling compensation, inertial-based integrated navigation systems under discontinuous observation conditions, and inertial-based brain integrated navigation systems.

This book identifies ten linguistic traps in our everyday language usage and provides philosophical justification for a method of determining internally consistent definitions of groups of related terms that avoid all ten traps.

This book aims to examine the multiple effects of the COVID-19 pandemic on China-Southeast Asia relations from both Chinese and Southeast Asian perspectives.

This book focuses on basic fundamental and applied aspects of micro-LED, ranging from chip fabrication to transfer technology, panel integration, and various applications in fields ranging from optics to electronics to and biomedicine.

This book presents state-of-the-art research on quantum hybridization, manipulation, and measurement in the context of hybrid quantum systems. It covers a broad range of experimental and theoretical topics relevant to quantum hybridization, manipulation, and measurement technologies, including a magnetic field sensor based on spin qubits in diamond NV centers, coherently coupled superconductor qubits, novel coherent couplings between electron and nuclear spin, photons and phonons, and coherent coupling of atoms and photons. Each topic is concisely described by an expert at the forefront of the field, helping readers quickly catch up on the latest advances in fundamental sciences and technologies of hybrid quantum systems, while also providing an essential overview.

This book covers recent advances of the fragment molecular orbital (FMO) method, consisting of 5 parts and a total of 30 chapters written by FMO experts.

This book provides different facets of India's agro and food processing industry in both organised and unorganised segments.

Polyphagous pests are primarily agricultural pests that feed on economically important agricultural and horticultural crops of wide taxonomic diversity across the globe. It brings together a unique perspective for researchers to learn effective pest management practices across all crops.

This book comprises select proceedings of the international conference ETAEERE 2020, and primarily focuses on renewable energy resources and smart grid technologies.

Lastly, the book proposes design strategies and calculational examples for large-scale application. Richly illustrated and including a wealth of worked-out examples, this book is ideal for all researchers, students and engineers who are just getting started in the dynamics of microwave chemistry.