Böcker utgivna av Springer Verlag, Singapore

This book presents essential information on the various concepts of biomechanics and kinesiology applied to human body, also describing in depth the understanding of the various physical and mathematical principles applied towards understanding of this science of movement. It tries to simplify this biological movement science by facilitating easy understanding of the various applications of the forces acting on the human body. This book provides a deep insight to the clinical gait analysis and it¿s interpretations with graphical outputs, it also covers important topics such as biomechanics of important human joints such as neck, shoulder, spine, hip, knee and ankle with their recent advances. It also includes chapters on biomechanical instrumentation and their interpretation. Another highlight of the book is chapters on biomechanical motion analysis systems used for athletes. This book offers a valuable resource for medical and paramedical students, researchers and clinicians practicing musculoskeletal and manual therapy, aiding researchers gaining insight to human biomechanics.

Ankylosing Spondylitis is a chronic autoimmune disease that affects about 1-3% of the world population. This debilitating disease affecting primarily young males exerts considerable socio-economic consequences. The exact pathogenesis of AS has not yet been fully understood; therefore, novel, detailed information sources are required. This book offers cutting-edge knowledge about the molecular basic and immunological mechanisms involved in the pathogenesis of Ankylosing Spondylitis. It is one of the scarce scientific resources discussing the environmental factors triggering the disease, along with the clinical manifestations, diagnostic methods, and treatments. This book covers the most recent and reliable researches and developments about spondyloarthropathies in order to provide elaborated, integrated guidance on the molecular mechanisms of Spondyloarthropathies. It will prove helpful for rheumatologists, immunologists, biologists, geneticists, and medical science students who wish to learn more about SpAs.

This book aims to highlight all the existing information available on first and mid-trimester imaging of palate in prenatal ultrasound and to develop a methodical approach in imaging the palate. As formation of the palate is completed by 11 weeks of gestation and as there are no evolving changes in palatine anatomy at the mid-trimester, diagnosis of palatine clefts can now completely be shifted to late first-trimester. First-trimester evaluation of palate is now gaining importance and a number of techniques have currently been proposed by different authors.This book covers the existing literature and recent 2D and 3D techniques in evaluating palate and helps in the early detection of palatine clefts in the first trimester. Orofacial clefting is one of the most common birth defects and the burden of it in developing countries is substantial. This book helps in improving the counseling options for the obstetrician and the couple early in gestation. It includes 2D and 3D images of various types of palatine clefts and the nuances in imaging the secondary palate extensively. 3D images of the palate also help the multi-disciplinary team especially the maxillofacial surgeons involved in managing orofacial clefts. It also includes videos for easy understanding.This book is a ready reckoner for the imaging specialists and students /trainees involved in prenatal diagnosis. It provides essential information in diagnosing orofacial cleft both to the novice and to the skilled professionals involved in the field of diagnostic fetal ultrasound.

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.

This book provides practical information on applications of multi-modal EEG monitoring in patients with severely neurologically diseases. The First part systematically introduces the modern EEG techniques, and multi-modal EEG monitoring system for severe neurological illness. In the second part, identification of EEG artifacts and interpretation of common abnormal EEG patterns is presented. Accompanying more than 50 typical cases and 200 EEG records, the following chapters discusses EEG¿s changes and clinical significance in coma, ischemic-hypoxic encephalopathy, status epilepsy, Creutzfeldt-Jakob disease, traumatic brain injury, and other diseases in details. In addition, application of multi-modal EEG in monitoring intracranial pressure and predicting suicide risk is also included. It will be a valuable reference for professionals in neurology, neurosurgery, emergency care, psychiatry, technology specialists of EEG and senior nurses with basic EEG monitoring knowledge.

This volume thoroughly describes the fundamentals of a new multidisciplinary field of study that aims to deepen our understanding of the human body by combining medical image processing, mathematical analysis, and artificial intelligence. Multidisciplinary Computational Anatomy (MCA) offers an advanced diagnosis and therapeutic navigation system to help detect or predict human health problems from the micro-level to macro-level using a four-dimensional, dynamic approach to human anatomy: space, time, function, and pathology. Applying this dynamic and ¿living¿ approach in the clinical setting will promote better planning for ¿ and more accurate, effective, and safe implementation of ¿ medical management. Multidisciplinary Computational Anatomy will appeal not only to clinicians but also to a wide readership in various scientific fields such as basic science, engineering, image processing, and biomedical engineering. All chapters were written by respected specialists and feature abundant color illustrations. Moreover, the findings presented here share new insights into unresolved issues in the diagnosis and treatment of disease, and into the healthy human body.

This book presents the latest knowledge on all aspects of osteoarthritis of the knee. Beyond offering a thorough evidence-based review of the available treatment options, it provides helpful information on such fundamental aspects as anatomy, biomechanics, biochemistry, etiology, pathogenesis, and radiologic assessment. The treatment-oriented chapters cover non-pharmacologic treatment, drug treatment, intra-articular drug and/or cell-based injection therapy, arthroscopic treatment, osteotomy, and joint replacement surgery. The goal is to equip the reader with a sound understanding of both the condition itself and the appropriate treatment strategy in different situations. The importance of taking into account factors such as the degree of arthritis, patient activity, lifestyle, and pain when formulating that strategy is emphasized. The fact that the book extends well beyond the description of surgical treatments means that it will be an excellent source of information and guidance forgeneral clinicians as well as for those who specialize in the management of musculoskeletal disorders.

The upcoming trends in healthcare are intended towards improving the overall quality of life. In the past,management of health issues were limited to clinics and hospitals and managing patient¿s data and analyzing it. This procedure was difficult and time consuming. A great effort was also needed in diagnosing the cause and type of disease, but this all has changed now. As advancement in research and technologies, a positive impact on healthcare is seen. This book assesses the need and era of smart healthcare and delivers content relevant to current age and time. It describes the trend, usage and practicality of IWMDs i.e. Wearable Medical Device or Sensors (WMSs) and Implantable Medical Devices (IMDs) and how they enhance the awareness of daily healthcare.It establishes a relation and conjunction of daily healthcare monitoring with clinical healthcare. A healthcare system is called smart when there is an ability to make decisions, which comes from data analytics. Smart healthcare systems possess capability of data analytics and IoT based services which can be implemented on smart phones using cloud technology. This book discusses various research trends and technologies related to innovations and advancements for smart healthcare systems. It also elaborates challenges, scope upcoming techniques, devices and future directions for smart healthcare systems.The proposed book would in particular benefit researchers interested in interdisciplinary sciences, It would also be of value to faculty, research communities, and researchers from diverse disciplines who aspire to create new and innovative research initiatives.

The book covers all aspects of eye health in South-East Asia from public health to health system to education to industry in 6 sections. The World Health Organization (WHO) South-East Asia region comprises of 11 countries - Bangladesh, Bhutan, DPR Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste. This region is home to 26% of world population; there is a disproportionate amount of blindness (30.6%) and visual impairment (36%).This is a first of its kind book that discusses common conditions of visual impairment and blindness in the South-East Asia region. In addition, the book documents the current eye care industry in the region and the contribution of all eye health INGOs in eye care program planning and service delivery for many decades. Majority of the countries in the South-East Asia region are categorized in ¿middle-income country¿ group. This book discusses the common challenges in these countries such as, suboptimal public expenditure in health, acute shortage of skilled eye health workforce, and rudimentary health industry. The book covers the following 6 sections:1. Geographic description and health indices of the region2. Health system evolved over years, including universal eye health, health financing and health management information system (HMIS)3. Common eye problems including non-communicable disease NCD (and diabetic retinopathy), neglected tropical disease NTD (and Trachoma)4. Health workforce in the region that includes ophthalmologists, optometrists, and allied ophthalmic personnel5. Eye health support in the region of 13 international non-government organizations (INGOs) working for decades6. Eye health industry in the region that includes spectacles, ophthalmic devices and equipment and the pharma industry The book would be a useful resource for ophthalmologists, all public health personnel and policy makers in eye health in the South-East Asia region specifically and all ophthalmologists and scientists interested in public health all over the world as well as for program planning to reach the 'Health for All' strategy by 2030 (United Nations Sustainable Development Goal, SDG 2030).

This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, novel biomarkers, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments for possible functional cure of HBV infection.In this second edition, authors provides recent updates in epidemiology, biomarkers, antivirus therapy, and novel therapy for functional cure of chronic hepatitis B virus infection.The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection.

This book provides step-by-step illustrated descriptions of diverse vocal fold injection techniques, including some not previously described. The aim is to provide laryngologists in general, and especially those who are less experienced, with the detailed understanding and guidance needed in order to achieve optimal outcomes. Highly experienced experts describe approaches via the transoral, transnasal, and transcutaneous routes and offer guidance on indications, injection materials, pre- and postoperative care, and the management of complications. Special considerations that must be borne in mind when employing different vocal fold injection techniques, in different settings, are also carefully explained. In offering comprehensive, up-to-date information on this minimally invasive and cost-effective procedure, Vocal Fold Injection will be an essential aid for practitioners.

This book is designed to provide a crisp and necessary information for all the under-graduate and post-graduate medical students, Oral and Maxillofacial Surgeons, ENT Surgeons, General Surgeons, General Dentists and other health care workers who deal with TMDs in their practise. It includes contributions from eminent surgeons across the world who treat TMJ disorders and diseases using various conventional to modern state of the art techniques.Temporomandibular joint disorders (TMDs) are familiar yet difficult to diagnose in routine practice due to the complexity of the joint and its surrounding structures. The symptoms usually associated with TMDs present with pain, joint sounds such as click or crepitus, difficulty during mastication, reduced mouth opening are some of the many presentations. Definite diagnosis of the TMDs can be challenging as the patients present with varying symptoms. These disorders of the joint can vary from a simple disc displacement to complex pathologies. Management of the TMDs can be tricky and hence need a thorough evaluation of the joint and surrounding structures. There has been a tremendous leap in managing these disorders from simple conservative management to several advanced surgeries to salvage the joint. This compilation highlights all the relevant details regarding TMDs and its management which will offer utmost details to practising surgeons who often deal with TMDs. This book will be a delight to read for all the clinicians and surgeons who are interested in treating the small yet complex jaw joint in the facial region.

The book covers the essential practical techniques of flow cytometry in detail. It is divided into two sections: The first section includes the basic practical techniques of flow cytometry in cytology samples. Chapters under this section provide detailed description of the sampling technique, processing, acquisition of the sample, instrumentation and basic principles of flow cytometry. The second section elucidates clinical applications of flow cytometry. Chapters cover the flow cytometry applications in various haematolymphoid neoplasms, tumors of solid organs and body fluid samples. The flow cytometry findings of different tumors are described with the help of multiple colored cytology microphotographs, flow cytometry graphs, boxes, and tables. In addition, it also describes other ancillary techniques in those neoplastic lesions. The book helps practicing pathologists, technical staff and post graduate students to understand flow cytometry findings of the haematolymphoid neoplasms and solid tumor with special emphasis on cytology along with advanced technique. This book will help the students to interpret flow cytometry graphs.

This book covers interpretation of visual fields by Humphrey and Octopus perimeters and discussion of Humphrey visual fields in a variety of ocular disorders.It examines dilemmas faced by an ophthalmologist while evaluating visual fields which do not match with the clinical picture. Glaucoma, the commonest condition for visual field investigation is discussed in detail. Logical reasoningfor incorporating perimetry in glaucoma management with a clear understanding of the challenges in its interpretation is delved into. The book progresses to advanced glaucoma and glaucoma progression. It discusses a systematic evaluation of various parts of the visual field so that the reader can make a calculated management plan for their patient. Each chapter attempts to clearly enunciate factors that help in the diagnosis and features which may be confused with other conditions. Fields which help diagnosing early, advanced glaucoma and glaucoma progression with images and methods of ensuring reasonable diagnostic accuracy are included. The book incorporates separate chapters on ocular conditions which also mimic visual field defects of glaucoma with detailed modes of correct diagnosis, diagnostic dilemmas arising from retinal, macular, vascular, visual pathway lesions mimicking visual field defects of glaucoma or while coexisting with glaucoma, supported by algorithms to achieve a quick diagnosis in a busy OPD without missing the clinical findings and by using minimal investigative modalities. This book helps clinicians to prevent over diagnosis or under diagnosis of glaucoma and helps diagnose cases with morbidities causing visual field defects.

Each racial and ethnic population has their own nasal characteristics, which need to be considered when planning rhinoplasty surgery. This book is probably the first of its kind in the Indian context highlighting the goal of maintaining ethnic identity congruent with the patient¿s facial features and establishing Indian standards for gauging the success of the surgery. This is important as most of the rhinoplasty books have addressed these issues of the Caucasian or southeast Asian population and Caucasian normative standards of facial analysis. This book provides a broader understanding of ethnically specific features. It highlights the regional variations within India and their implications for rhinoplasty Surgery, thereby filling the void of lack of knowledge of the intricacies of surgery on Indian noses. It deals with important topics such as preoperative evaluations, determining factors such as thickness and texture of skin along with the various complications that may be encountered. It simplifies and facilitates learning with numerous pre-operative, intra-operative, and postoperative photographs. This book provides a systematic approach to Rhinoplasty surgery in Indian patients with an emphasis on addressing the functional aspects along with the cosmetic aspects.This book is a must-have for trainees in rhinoplasty and plastic surgery courses along with facial plastic surgeons, maxillofacial surgeons, and aesthetic surgeons operating on the Indian population across the globe.

This book offers a comprehensive overview of the latest standard medical procedures and surgical techniques for biliary atresia (BA), as well as the perioperative care, long-term follow-up and transitions. Experts on pediatrics in such fields as hepatology, surgery, pathology, and liver transplantation present their research findings and analyses of this rare and intractable disease of unknown etiology. In Japan, shared experience and sound understanding based on conferences and guidelines have led to standardization of management and clinical care and, as a result, better outcomes. Providing insights into improving surgical outcomes, and including special chapters focusing on social support systems for patients and families as well as recent advances in early diagnosis, this book a valuable resource for medical professionals around the globe who are involved in treating biliary atresia. It is especially useful for pediatric hepatologists, pediatric surgeons and transplant surgeons.

This book provides practitioners with comprehensive guidance on the application of 3D printing technology in the bone reconstruction. The 3D printed implants need to be able to maximize function and minimize complications by reinforcing strength and changing shape beyond anatomically identical design. Many of the clinical cases in this book, including pre-operative images, surgical planning, design and fabrication, 3D printing implants and guides, surgery and postoperative images, will suffice to capture the sensation of the 3D printing bone reconstruction. This book is composed of photos with minimum descriptions so that the readers can develop their imaginative view.

This Atlas covers various types of lip and nose deformities and introduces individualized surgical plan for patients. The surgical techniques are classified according to the various types of deformities. Schematic diagrams, pre-operative and post-operative photographs are supplemented by detailed explanations. It consists of four parts: anatomical structure of lips and nose; cosmetic surgery of lips and nose; plastic surgery of nasolabial congenital deformity; plastic surgery of acquired nasolabial defect and deformities.The management of nasolabial deformities and defects crosses many surgical disciplines, and therefore, this book recommended to be read by surgeons of different backgrounds i.e. oral and maxillofacial surgery, plastic surgery, cosmetic surgery, otorhinolaryngology, etc. It can also be used as a reference for anatomy, developmental biology, physiology, linguistics, aesthetics and other basic medical sciences.

The book covers all clinical aspects of pediatric cataract surgery. Chapters cover basic sciences, etiology, pre-operative evaluation, choice of intraocular lenses, steps of surgery, complications, considerations in traumatic cataract and post-operative rehabilitation. It includes photographs, diagrams, flow charts and tables for easy memorization and understanding. Multiple choice questions at the end of each chapter help to evaluate the understanding and reinforce important concepts.The book aims to encourage ophthalmic surgeons to successfully treat children with cataract as all of them perform adult cataract surgeries but usually avoid managing pediatric cases. This hesitation is primarily due to exhaustive pre-operative evaluation and long term follow up. As a result the back log of this disease in the developing world is significant and many such children are unable to receive timely intervention during their crucial period of visual development. The chapters primarily focus on the clinically relevant issues to keep the reader interested. The book includes contributions from some of the most talented and experienced pediatric cataract surgeons.The book is relevant for ophthalmologists not commonly practicing pediatric cataract surgery and post graduate students.

This book presents the epidemiology of birth defects and their public health and social implications in India. As neglected childhood disorders, birth defects remain invisible in global maternal and child health dialogues. Birth defects services are emerging in India. This book approaches birth defects from a public health perspective, identifying the core functions of a birth defects service. Keeping in mind the complex task of providing multidisciplinary services for children with disabilities and complex medical conditions, the book examines the basic public health activities that have been put in place to address these conditions in India. The book describes birth defects surveillance and the challenges of acquiring accurate and timely data on birth defects against the background of Indiäs mixed health system. It discusses opportunities for prevention of birth defects and describes the structure and function of an emergent genetic service. It explores issues related to an integrated service for children with special healthcare needs, such as screening, early intervention, and rehabilitation. Furthermore, it describes the impact of these conditions on caregivers, including birth defects stigma. This book not only addresses a knowledge gap in the field of public health in India, but also explores the broader issues of services for children with disabilities and disabling conditions in low and low-middle income settings where access to health care is not universal. Given the depth and breadth of its coverage, the book offers an essential resource for birth defects researchers, researchers in the field of maternal and child health, public health/ global health, disability researchers, and researchers from the fields of rehabilitation sciences, nursing and anthropology. This book will be a valuable read for social medicine/community medicine departments, global health courses, and public health schools in India and other low middle-income countries.