Böcker utgivna av Springer Verlag, Singapore

This book brings together papers from the 2018 International Conference on Communications, Signal Processing, and Systems, which was held in Dalian, China on July 14-16, 2018. Presenting the latest developments and discussing the interactions and links between these multidisciplinary fields, the book spans topics ranging from communications, signal processing and systems. It is aimed at undergraduate and graduate electrical engineering, computer science and mathematics students, researchers and engineers from academia and industry as well as government employees.

This book provides a brief overview of single-cell analysis using recent advanced technologies. The different sections cover different aspect of single cell analysis and applications with their advantages, limitations, and future challenges. The book has covered how different physical energies such as optical, electrical, and mechanical energy have been applied for single cell therapy and analysis. The recent advanced micro/nanofluidic devices have been employed for single-cell counting, manipulation, cultivation, separation, isolation, lysis, printing and patterning and host-viral interaction at single-cell level. Various chemical approaches for single-cell analysis have been discussed, such as liposome mediated materials transfer at single-cell and their analysis, discovery of antibody via single-cell, high-throughput screening of antigen-specific antibody-secreting cells, and biomolecular secretion analysis of individual cells. Moreover, different single-cell omics such as genomics, proteomics and transcriptomics have been discussed using microfluidic technologies as well as conventional approaches.The role of single cell analysis in system biology and biocatalysis have been discussed in detail. The book describes single-cell phenotyping of heterogeneous tissue, stimulation, and instant reaction quenching technology for biochemical kinetic analysis, large scale single-cell assay for the identification of biocatalysts and analytical techniques for single-cell studies in microbiology. The role of single-cell analysis in cancer, such as single-cell adhesion and cancer progression, single-cell technologies for cancer therapy, analytical technology for single cancer cell analysis, and biophysical markers for cancer cell analysis have been discussed. The flow cytometry based high throughput single-cell analysis have been well emphasized. Finally this book has covered single-cell electrophysiology, single-cell sensing and size measurement using mechanical and microwave resonators, molecular force spectroscopy for cell adhesion measurement, micro-tweezers and force microscopy techniques for single-cell mechanobiological analysis, mass spectrometry and acoustic tweezers for single-cell manipulation and analysis. This book is intended for academic and industrial researchers, undergraduate and graduate students in the fields of biomedical engineering, bio-micro/nanoengineering, and bio-micro/nano fabrication for single-cell analysis. It can be used for courses on bio-MEMS/bio-NEMS, biomicrofluidics, bio-micro/nanofabrications, micro/nanofluidics, biophysics, single cell analysis, bionanotechnology, drug delivery systems and biomedical microdevices. Collective contributions from respected experts, have brought diverse aspects of single-cell technologies in a single hand book. This will benefit researchers and practitioners in the biotechnology industry for different diseases analysis, therapeutics, diagnostics, drug discovery, drug screening etc.In addition to hard copies, the book will be available online and will often be updated by the authors.

This book systematically assesses the risk of 21 major infectious diseases threatening BRI countries. It consists of 14 chapters. Chapter 1 is an overview. Chapter 2 introduces the history of health cooperation between China and other BRI countries. Chapters 3-14 introduce the prevalence of major infectious diseases threatening BRI countries such as cholera, vaccine preventable diseases (polio, measles, meningitis, Japanese encephalitis, diphtheria, hepatitis A), tuberculosis, influenza, and insect-borne diseases (Dengue fever, Zika virus disease, yellow fever, Chikungunya, Rift Valley fever), plague, malaria, Ebola virus disease, MERS, schistosomiasis, COVID-19 and AIDS, and risk factors, principles and cases of their prevention and control. It is a useful reference book in the research of infectious disease control and prevention, and provides historical experience and lessons learned. It also provides decision support for international cooperation among BRI countries in the field of epidemic prevention and control in the future.

The book provides a detailed description in color format of the optic nerve head changes that occur in glaucoma. It explains the normal and variant anatomy of an optic nerve head and why certain discs are more or less likely to develop glaucomatous changes.This book attempts to explain the anatomical basis of common and not so common signs seen in optic nerve head and retinal nerve fibre layer as captured by a digital fundus imaging system and optical coherence tomography. It also includes optic nerve head conditions mimicking glaucoma. The book is relevant for practicing ophthalmologists, vision science researchers, clinical optometrists, postgraduate residents in ophthalmology, sub-specialty fellows as well as general ophthalmologists, neurologists and neurosurgeons.

This book amalgamates the basic concepts in understanding the science of maxillofacial skeleton with the clinical skills required towards managing complex facial fractures. The book is presented in two sections. The first section introduces the readers with the introduction to maxillofacial trauma, biomechanics of maxillofacial skeleton, the principle of internal fixation, medicolegal aspects of maxillofacial trauma, and preoperative workup which provides a brief outline towards an understanding of the basic concepts about the anatomy and physiology of facial skeleton. The second section is oriented clinically with case-based discussions that start from the emergency management of facial trauma including the recent protocols of basic life support and advanced trauma life support, emergency airway management followed by definitive management guidelines in stabilizing and fixing the fractured facial bones. The clinical cases have been discussed in a way to provide practical knowledgeand skills to the postgraduate students and clinicians who will enhance their knowledge and facilitate the decision-making process. This book would be a valuable read for clinicians in oral & maxillofacial surgery, ENT surgery, plastic surgery and allied trauma specialists dealing with maxillofacial trauma.

This book introduces the surgical suture techniques in orthopaedics. These techniques have been recognized as a crucial part for wound care and surgery-related prognosis. Training of fellows on suture techniques is of great importance. This book provides a standard tutorial on how to be proficient in surgical suture performance. The history and basic concepts are introduced. Important issues when considering suture methods, including site infections, suturing materials, room setups, cosmetics and drainage are also discussed fully. Different types of suture techniques applying to orthopaedic surgeries are presented with illustrations.The author strives to implement the principle that orthopaedic theory should be connected with clinical practice, highlight the application of theoretical knowledge, strengthen the pertinence and practicality of suture techniques, and reflect domestic and international development trends to the greatest extend.

Clinical Rheumatology is a book written by a clinician for clinicians. It covers all the essential clinical aspects of Rheumatology in an engaging, clear, and concise manner, thereby fulfilling an unmet need. The focus of this book is to cover clinically pertinent and practically relevant issues while pruning unnecessary detail. Patient photographs, tables, and boxes enhance readability. The bedside clinical and investigative approach is discussed in a lucid fashion illustrated by clinical photographs, flowcharts, and algorithms. The evidence-based treatment is spelt out in an easy to comprehend fashion. Key messages have been listed at the beginning of each chapter. The book is intended for undergraduate and postgraduate medical students, residents, fellows, and clinicians who want to gain practical knowledge and clinical insight into rheumatic diseases. The book is likely to appeal to internists, rheumatologists, physiatrists, physiotherapists, occupationaltherapists, as well as orthopaedic surgeons. They will find their day to day questions answered in a knowledge format that can be applied straight away. Senior clinicians will find it a ready reckoner and a handy manual to refresh and update their knowledge. Basic scientists will find it useful to gain clinical insight into the rheumatic diseases they research without being intimidated by the size of the text. Teachers will find it full of helpful teaching messages. Clinical Rheumatology is a must-have book for all those who deal with rheumatic musculoskeletal diseases.

This book covers the entire spectrum of gestational trophoblastic disease from the most benign to the most malignant form. It addresses etiopathogenesis, molecular basis of the disease, risk assessment, management and follow-up. Management in the form of surgical, medical and supportive care is discussed in detail to help the practitioner in making treatment decisions. Special and rare varieties of the disease are dealt separately. A separate section in each chapter covers critical conditions arising from the disease. Case based discussions make the chapters more lively and interesting. The recent trials and studies are also covered in the book. Topics such as fertility preservation, gestational trophoblastic diseases registry and development of voluntary organizations for supporting patients are value additions to this book. This book is meant for the general obstetrician and gynecologist and for the gynecologic oncologist as well.

This book describes the fundamentals of microfluidics and fabrication methods of microfluidic devices that can be adopted for animal-assisted reproduction. It presents microfluidic methods for sorting highly fertile spermatozoa. This book also describes the application of microfluidics in vitro fertilization and embryo culture. It discusses the use of microfluidics in sperm sexing and the cryopreservation of animal gametes and embryos. Lastly, the book examines the potential opportunities of microfluidics in infertility diagnosis, sperm selection and guidance, oocyte selection, insemination, and embryo monitoring.

This atlas presents dermoscopic-histopathological correlations of dermatologic and pathological presentations seen in the Asian subcontinent. The disorders have been explained with the help of state of the art clinical, dermoscopic and pathological figures of various entities in skin of color. The format has been kept simple and easy to understand which is deciphered through dermoscopic and histopathological correlation. This title also emphasizes on atypical presentations and rare dermoscopic features with the help of thorough description covering clinical and pathological manifestations, diagnosis, and differential diagnosis.Written for dermatologists, dermato-pathologists, dermoscopists and residents of dermatology, this atlas is a detailed visual guide to effectively evaluate and diagnose various skin disorders.

The book covers advances in critical care pediatric nephrology, including care of sick children with acute kidney injury. The book contains detailed guidance on point of care ultrasound in children with acute kidney injury and use of biomarkers in critically sick children.This is an annual theme-based book with the current theme of 'point of care ultrasound in critical care pediatric nephrology and newer diagnostics in acute kidney injury'. This is the first book of the set of books to be published annually with a different theme related to critical care pediatric nephrology each year with the collaboration of the Pediatric Continous Renal Replacement Therapy (PCRRT) Foundation and International Collaboration of Nephrologists & Intensivists for Critical Care in Children (ICONIC). This annual updates book contains 20 chapters, written and edited by leading experts in pediatric intensive care, pediatric nephrology and nephrologists specializing in point of care ultrasound from across the globe. It includes top studies in the last few years in critical care pediatric nephrology on point of care ultrasound and diagnostics. Chapters cover scientifically updated information by international experts on each topic. It offers assistance to pediatricians, pediatric nephrologists, pediatric intensivists and residents.

The main focus of this book is providing evidence on and interpreting the risks associated with heated tobacco products (HTPs) in terms of their health effects and social effects; in addition, the author introduces a harm reduction theory related to HTPs and electronic cigarettes. The book also addresses the history of these products, their marketing strategies, and policy implications. These products are new and the accompanying health risks have yet to be determined. However, since Japan accounts for more than 80% of the world¿s market for IQOS, the most popular heated tobacco product, researchers around the globe will be very interested in the outcomes. Written by a leading researcher in the field of tobacco control, Science and Practice for Heated Tobacco Products offers a valuable, unique resource for researchers in the fields of epidemiology, public health, social sciences, addiction, and tobacco research. Since tobacco is associated with a host of diseases including cancers, cardiovascular diseases, diabetes mellitus, and respiratory illnesses, researchers and healthcare workers whose work involves these diseases will find this book both thought provoking and insightful.

This surgical manual provides a step-by-step guide to various surgical procedures for patients with thyroid eye disease (TED). The key surgical steps are covered in detail, with intra-operative photographs. The manual addresses all aspects of TED, including the basic anatomy, surgical preparation, evaluation of imaging, and surgical procedures. TED is commonly encountered by oculoplastic surgeons and general ophthalmologists in their daily practice, and restoration of the normal appearance is vital to patients and their families. Surgical treatments for TED include basic oculoplastic surgery, complex eyelid surgery, strabismus surgery, orbital surgery, and aesthetic procedures.All of the contributing authors are eminent experts with vast experience in treating TED. High-resolution images will help readers understand the key surgical steps, and are combined with a minimal amount of text, reflecting the book's focus on surgical technique. Offering a complete guide that contains all relevant surgical knowledge on TED, presented in a highly practice-oriented format, the book is a must-read for every surgeon whose work involves managing TED.

This surgical manual provides a step-by-step guide to various surgical procedures for patients with thyroid eye disease (TED). The key surgical steps are covered in detail, with intra-operative photographs. The manual addresses all aspects of TED, including the basic anatomy, surgical preparation, evaluation of imaging, and surgical procedures. TED is commonly encountered by oculoplastic surgeons and general ophthalmologists in their daily practice, and restoration of the normal appearance is vital to patients and their families. Surgical treatments for TED include basic oculoplastic surgery, complex eyelid surgery, strabismus surgery, orbital surgery, and aesthetic procedures.All of the contributing authors are eminent experts with vast experience in treating TED. High-resolution images will help readers understand the key surgical steps, and are combined with a minimal amount of text, reflecting the book's focus on surgical technique. Offering a complete guide that contains all relevant surgical knowledge on TED, presented in a highly practice-oriented format, the book is a must-read for every surgeon whose work involves managing TED.

The book covers all aspects of endoscopic biopsies of the stomach inclusive of gastritis and gastropathies. It highlights the best way of handling of endoscopic biopsies in the endoscopic room by the gastroenterologist. It elucidates various steps involved in processing of the biopsy, tissue embedding and paraffin sectioning, approach to interpretation, various precautions that require to be taken while interpreting the biopsies, and the essential background knowledge of the interpreter. The book highlights the importance of the little things for a proper reading like matching of the tissue fragments received and the number of tissue present on a slide after the paraffin section.Chapters cover various forms of gastritis, and the easiest approach for daily routine by avoiding the cumbersome classifications and staging formulated for gastritis. It also discusses the utilization of the right nomenclature for acute and chronic gastritis and various other subtypes of gastritis. Chapters include various rarer and infrequently come across conditions of both acute and chronic gastritis, special form of gastritis and infective conditions. It also includes unusual forms of non-neoplastic gastric pathologies such as, a condition, where the gastric mucosa is affected not only by direct exposure to various irritants but may also be affected by many systemic diseases. It also highlights the frequently observed changes in chronic renal and liver failures. The book is targeted to all the practicing pathologists as well as graduate and post graduate students who are keen to learn about non-neoplastic gastric pathology at various levels.

This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly.Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of ¿Remodeling¿ and ¿Modeling¿ is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are includedTreatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.

This book is aimed at illustrating the common complicated ocular trauma with typical signs, examinations, surgical procedures and conservative management to clinical practitioners including the nurses, medical students, residents, fellows and ophthalmologists, and help them make the most appropriate decision on the diagnosis and management of such patients. There are 23 chapters introduced in the book, which covers all types of complicated ocular trauma with brief case reports combined with the most comprehensive pictures. For each disease, a brief introduction, explanation as well as management are offered to the readers. With the illustrative figures and explanations, the goal of making the right diagnose, offering the best advice or treatment to the patients, and understanding surgical procedures would be easily achieved. This book is useful for readers to be fully prepared for the challenge of complicated ocular traumatic cases.This is the fifth volume of the book series Ocular Trauma.