Böcker utgivna av Springer-Verlag New York Inc.

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build.

In order to make this a useful resource for researchers at all levels, the basic structure of each chapter is the same, so that information can be easily consulted from chapter to chapter.

This timely volume surveys the broad spectrum of interventions used in health promotion, and shows how they may be tailored to the developmental needs of children and adolescents. Its multilevel lifespan approach reflects concepts of public health as inclusive, empowering, and aimed at long- and short-term well-being. Coverage grounds readers in theoretical and ecological perspectives, while special sections spotlight key issues in social and behavioral wellness, dietary health, and children and teens in the health care system. And in keeping with best practices in the field, the book emphasizes collaboration with stakeholders, especially with the young clients themselves.Among the topics covered: Child mental health: recent developments with respect to risk, resilience, and interventions Health-related concerns among children and adolescents with ADD/ADHD Preventing risky sexual behavior in adolescents Violence affecting youth: pervasive and preventable Childhood and adolescent obesity Well-being of children in the foster care system Health Promotion for Children and Adolescents is a necessary text for graduate or advanced undergraduate courses in public health, education, medicine, psychology, health education, social work, curriculum, nutrition, and public affairs. It is also important reading for public health professionals; researchers in child health, health education, and child psychology; policymakers in education and public health; and teachers.

This clinically focused and authoritative guide to managing End Stage Renal Disease (ESRD) patients provides the essentials of hemodialysis, peritoneal dialysis, and continuous therapies.

Each disease-specific chapter discusses biology, disease course, and appropriate therapeutic interventions, covering plasma cell leukemia, plasmacytoma, POEMS Syndrome and Castleman's Disease, Waldenstroem macroglobulinemia, immunoglobin deposition disease, and cryoglobulinemic syndromes, among others.

This title is a comprehensive text that addresses key aspects of nanomedicine such as properties occurring at the nanoscale that have unique medical effects, great molecular knowledge of the human body and disease processes, and apparent clinical translation as opposed to narrow insufficient texts that address only a few topics and attempt to "rebrand" established drug delivery. It will clearly define the field which is needed due to the immaturity and broad nature of the field. The book is aligned with both the USA and European roadmaps for nanomedicine and will address initiatives taken in Asia that ensures timely and relevant content. In-depth chapters ensure each section is adequately covered. The nanopharmaceutical section focuses on novel drug delivery systems relevant to nanomedicine and the book has an extensive section on immune recognition at the nanoscale which has implications for in vivo applications of nanomedicines. ¿

This contributed volume presents the experiences, challenges, trends, and advances in Service Science from Japan's perspective. As the global economy becomes more connected and competitive, many economies depend the service sector on for growth and prosperity. A multi-disciplinary approach to Service Science can potentially transform service industries through research, education, and practice. Offering a forum for best practices in Service Science within Japan, the volume benefits its audience by sharing viewpoints from a wide range of geographical regions and economies. The book is organized as follows:. Foundations of Service Science and the service industry sector. Public/Private sector partnerships, policies, trade in services, future prospects. Contributions from science, social science, management, engineering, design as well as industry sector perspectives. Road-maps, methodology, business development, strategies and innovative models, application of information technology, performance measures, and service system design. Education and workforce development. Case studies from practice, research and educational community. Future Directions in JapanThis book includes three Forewords written by key leaders in Service Science:. Takayuki Aso (Ministry of Education, Culture, Sports, Science & Technology in Japan). Yasuhiro Maeda (Director, Service Affairs Policy Division METI). Norihisa Doi (Professor Emeritus, Keio University and Service Science, Solutions and Foundation Integrated Research (S3FIRE) Program Officer, JST/RISTEX)

This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics.

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations.

Echolocation by bats has proven to be a virtual gold mine for colleagues studying neurobiology, while providing many rich examples of its impact on other areas of bats' lives. This includes an examination of the possible roles of Prestin and FoxP2 genes and various anatomical features affecting bat vocalizations.

Whereas power systems have traditionally been designed with a focus on protecting them from routine component failures and atypical user demand, we now also confront the fact that deliberate attack intended to cause maximum disruption is a real possibility. In response to this changing environment, new concepts and tools have emerged that address many of the issues facing power system operation today. This book is aimed at introducing these ideas to practicing power systems engineers, control systems engineers interested in power systems, and graduate students in these areas.The ideas are examined with an emphasis on how they can be applied to improve our understanding of power system behavior and help design better control systems. The book is supplemented by a Mathematica package enabling readers to work out nontrivial examples and problems. Also included is a set of Mathematica tutorial notebooks providing detailed solutions of the worked examples in the text. In addition to Mathematica, simulations are carried out using Simulink with Stateflow.

This book introduces recovery and stabilization of common bioactive materials in foods as well as materials science aspects of engineering stable bioactive delivery systems.

It will be of interest to researchers and practitioners in time series, econometricians, and graduate students in time series or econometrics, as well as environmental statisticians, data scientists, statisticians interested in graphical models, and researchers in quantitative risk management.

This guide provides a comprehensive review of the full spectrum of hypertension in chronic kidney disease (CKD). Specialist patient populations and hypertension and causes of hypertension are also covered in detail.

CT afferents are receptors in mammalian hairy skin that fire action potentials when the skin is touched lightly which makes them particularly important in affective touch.

An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a "repressor" of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals.

This forward-looking resource recasts the concept of healthy cities as not only a safe, pleasant, and green built environment, but also one that creates and sustains health by addressing social, economic, and political conditions. It describes collaborations between city planning and public health creating a contemporary concept of urban governance¿a democratically-informed process that embraces values like equity. Models, critiques, and global examples illustrate institutional change, community input, targeted assessment, and other means of addressing longstanding sources of urban health challenges. In these ambitious pages, healthy cities are rooted firmly in the worldwide movement toward balanced and sustainable urbanization, developed not to disguise or displace entrenched health and social problems, but to encourage and foster solutions.Included in the coverage: Towards healthy urban governance in the century of the city

This is the first book on digital fingerprinting that comprehensively covers the major areas of study in a range of information security areas including authentication schemes, intrusion detection, forensic analysis and more.

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In this book, leading figures in the field of Developmental Origins of Health and Disease provide up-to-date information from human clinical trials, cohorts, and animal physiology experiments to reveal the interdependence between parental obesity and health of the offspring.

Due to the fact that Restless Legs Syndrome/Willis-Ekbom Disease is usually a chronic condition, this book aims to provide physicians with the necessary tools for the long-term management of patients with RLS.

This book provides comprehensive coverage of verification and debugging techniques for embedded software, which is frequently used in safety critical applications (e.g., automotive), where failures are unacceptable.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery.

The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

This book is based on selected papers from keynote and symposium sessions given at the 16th International Union of Food Science and Technology (IUFoST) World Congress, held in Foz do Iguacu, Brazil August, 2012.

This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.

This informative text details the many changes in everyday life as the result of injury, illness, or aging affecting the brain. Experts across brain-related fields trace mechanisms of conditions such as Parkinson's disease, TBI, and dementia as they impact regions of the brain, and resulting cognitive, emotional, sensory, and motor impairments as they contribute to deficits in personal and social functioning. In addition to symptoms and behaviors associated with insults to the brain (and the extent to which the brain can adapt or self-repair), chapters provide cogent examples of how societal and cultural expectations can shape the context and experience of disability. The book's focus on everyday activities brings new clarity to diverse links between symptoms and diagnosis, brain and behavior.Included in the coverage:·The aging brain and changes in daily function.·Stroke: impact on life and daily function.·Traumatic brain injury (TBI) and the impact on daily life.·Everyday life with cancer.·Real-world impact of HIV-associated neurocognitive impairment.·Disability and public policy in America.·Living after brain changes, from the patient's perspective.Rich in empirical data and human insight, Changes in the Brain gives neuropsychologists, clinical psychologists, clinical social workers, and rehabilitation nurses a robust new understanding of the daily lives of patients, both in theory and in the real world.

This handbook compiles state-of-the-art empirical studies and applications using Data Envelopment Analysis (DEA). It includes a collection of 18 chapters written by DEA experts. Chapter 1 examines the performance of CEOs of U.S. banks and thrifts. Chapter 2 describes the network operational structure of transportation organizations and the relative network data envelopment analysis model. Chapter 3 demonstrates how to use different types of DEA models to compute total-factor energy efficiency scores with an application to energy efficiency. In chapter 4, the authors explore the impact of incorporating customers' willingness to pay for service quality in benchmarking models on cost efficiency of distribution networks, and chapter 5 provides a brief review of previous applications of DEA to the professional baseball industry, followed by two detailed applications to Major League Baseball.Chapter 6 examines efficiency and productivity of U.S. property-liability (P-L) insurers using DEA, while chapter 7 presents a two-stage network DEA model that decomposes the overall efficiency of a decision-making unit into two components. Chapter 8 presents a review of the literature of DEA models for the perfoemance assessment of mutual funds, and chapter 9 discusses the management strategies formulation of the international tourist hotel industry in Taiwan. Chapter 10 presents a novel use of the two-stage network DEA to evaluate sustainable product design performances. In chapter 11 authors highlight limitations of some DEA environmental efficiency models, and chapter 12 reviews applications of DEA in secondary and tertiary education.Chapter 13 measures the relative performance of New York State school districts in the 2011-2012 academic year. Chapter 14 provides an introductory prelude to chapters 15 and 16, which both provide detailed applications of DEA in marketing. Chapter 17 then shows how to decompose a new total factor productivity index that satisfies all economically-relevant axioms from index theory with an application to U.S. agriculture. Finally, chapter 18 presents a unique study that conducts a DEA research front analysis, applying a network clustering method to group the DEA literature over the period 2000 to 2014.

Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury (SCI). This book will present comprehensive information on the unique physiologic effects of SCI and the potential role of exercise in treating and mitigating these effects.