Böcker utgivna av Springer-Verlag New York Inc.

This book shows how to align strategy, organization design, human resource management and e-business practice in developing successful social networking programs, taking into account the global financial crisis and challenges to traditional business models.

Environmental changes irrespective of source cause a variety of stresses. This book examines abiotic stress responses in plants. It encompasses the collected insights and research of the foremost authorities in the plant sciences.

In order to facilitate understanding of the topic, the initial part of the textbook will review neurophysiological systems involved in neuromodulation and will provide readers with basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine.

This book reviews and examines the quality assurance systems of Library and Information Science (LIS) education in a variety countries and regions, including Asia, North America, Latin America and Europe.

This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid-associated eye diseases (TED).

The volume on Industrial Crop Breeding will be part of the series, Handbook of Plant Breeding. We hope to encourage the proposed authors of new crops to provide an estimate of the crop readiness for commercial development and discuss the limitations.

Essential Cardiology: Principles and Practice, 3rd Edition, blends molecular, cellular, and physiologic concepts with current clinical practice and provides up-to-date information on all major aspects of cardiovascular disease. It includes new chapters on cardiovascular disease in women;

Injuries to the hamstring and quadriceps muscles can occur in both low- and high-impact sports and as such are among the more common injuries incurred by athletes.

During the last 200 years the purpose of food processing was a-safety(sterilization, Pasteurization,1804 Nicholas Apert,Pasteur 1867), and b-prevention of deficiency diseases(Enrichments),but MPR foods provides a two new dimensions to food processing ;

This book highlights key results and lessons learnt from two field sites, La Suerte in Costa Rica and Ometepe Nicaragua. This book strongly calls for new approaches in conservation, it makes the case for looking beyond the pure species biology and classic conservation angle and to take into account the economic and political realities.

This authoritative reference examines in depth the myriad challenges facing pediatric cancer survivors and proposes a robust framework for structured follow-up of these patients through adulthood. Approaches to long-term follow-up include both established models of care and targeted models of lifelong surveillance of late effects by bodily systems and neurological outcomes. Sections devoted to quality of life and re-entry after treatment focus on key concerns such as health risk behaviors, school and career issues, psychological challenges, and care disparities. And a robust resources section adds extra usefulness to the expert coverage. Among the Handbook's topics:¿ Developmental considerations in the transition from child and adolescent to adult survivorship. ¿ Long-term follow-up roadmaps by disease and treatment. ¿ Neuropsychological effects of pediatric brain tumors and associated treatment. ¿ Building resiliency in childhood cancer survivors: a clinician¿s perspective. ¿ School issues and educational strategies for survivors of childhood cancer. ¿ Educating and preparing the childhood cancer survivor for long-term care: a curriculum model for cancer centers. A work of rare scope, scholarship, and clinical acumen, the Handbook of Long-Term Care of the Childhood Cancer Survivor is a rewarding, practice-building resource essential to a wide range of healing professionals, including primary care physicians, pediatricians, oncologists, nurses, psychologists, neuropsychologists, child psychologists, and licensed therapists.

Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the worldΓÇÖs population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HSCT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as:┬╖       Molecular socioepidemiology┬╖       Global HIV and NeuroAIDS┬╖       Neuropathology┬╖       cART and blood-brain barrier penetration┬╖       HIV replicative oscillations┬╖       HIV and SIV evolution┬╖       Psychiatric comorbidities┬╖       Neurosyphilis ┬╖       The examination of current and innovative models of translational research to translational effectiveness

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.

Gathering papers from the 8th Pan-Hellenic Conference on ICT in Education (HCICTE 2012), this book covers such topics as ICT-based Learning; Educational Gaming; Social Networks for Learning and Knowledge Sharing; ICT and Instructional Design and more.

Fashion Branding and Consumer Behaviors presents eye-opening theory, literature review and original research on the mutual influence of branding strategies and consumer response.

This book takes a practical, evidence-based approach that offers educators effective and respectful tools to work with trainees who fall short of standards. Covers learning disabilities, issues of diversity, educational and psychiatric issues and much more.

Since 1998, the world's leading experts on accounting and regulation have convened in a series of workshops to explore and analyze emerging issues in the field. In this volume, the editors showcase contributions from the workshops that represent the full spectrum of issues and perspectives relating to accounting and regulation.

In this book, some of the most qualified scientists review different food safety topics, ranging from emerging and reemerging foodborne pathogens, food regulations in the USA, food risk analysis and the most important foodborne pathogens based on food commodities.

Optic Nerve Disorders: Diagnosis and Management, Second Edition, is a thoroughly revised and updated reference, including new information on diagnostic techniques such as genetic testing for hereditary optic neuropathies, new data on toxic/drug-related optic neuropathies and recent data from clinical trial studies.

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products.Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulationsDetails the latest developments in instrumental analysis and controlled ice nucleation technology Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeuticsDetails an exhaustive update on quality-by-design and process analytical technology  approaches, illustrated superbly by case studies and FDA perspectiveProvides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studiesProvides a step-by-step guide through critical considerations during process scale-up, technology transfer,packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launchChapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

This title will provide an up-to-date review of the emerging practice of neurology telemedicine.

This book outlines the current understanding of how obesity affects female reproductive function across the lifespan. Obesity and Fertility provides advice for reproductive medicine physicians and gynecologists to help guide obese patients toward improved reproductive health and outcomes.

This book describes the emergence of landscape ecology, its current status as a new integrative science, and how distinguished scholars in the field of landscape ecology view the future regarding new challenges and career opportunities.

Histories of Transnational Crime provides a broad, historical framework for understanding the developments in research of transnational crime over the centuries.

This comprehensive yet concise book introduces people at all levels of training-undergraduate, graduate, and medical students, residents, fellows, and junior faculty-to the basic joys and challenges of biomedical research.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build.