Böcker utgivna av Nova Science Publishers Inc

Originally published in 1866, this book offers great historical significance of the contemporary views of the nature, necessity, extent, authority, origin, ground, and constitution of government, and the unity, nationality, constitution, tendencies, and destiny of the American Republic.

This book, originally published in 1920, is remarkably yet unsurprisingly still relevant today. It delves into the processes of human nature, from our simple inborn impulses and needs to the most complete fulfillment of these in the deliberate activities of art, science, morality, and religion. This book will give you knowledge of the fundamentals of human nature and a sense of the possibilities and limits these give to human enterprise.

In all times and ages, the deeds of the men who sail the deep as its policemen or its soldiery have rightfully been sung in praise, but there are triumphs to be won by sea and by land greater than those of war, dangers to be braved more menacing than the odds of battle. The daily life of those who go down to the sea in ships is one of constant battle, and the whaler caught in the ice-pack is in more direful case than the blockaded cruiser. The captain of the ocean liner, guiding through a dense fog his colossal craft freighted with two thousand human lives, has on his mind a weightier load of responsibility than the admiral of the fleet. This book, originally published in 1902, is a timeless tribute and historically significant chronicle of the high courage, the reckless daring, and oftentimes the noble self-sacrifice of those who use the seven seas to extend the markets of the world, to bring nations nearer together, to advance science, and to cement the world into one great interdependent whole.

This book raises very important issues that concern the severe hypercholesterolemia phenotype. The severe hypercholesterolemia phenotype such as familial hypercholesterolemia (FH) is characterised by increased plasma low density lipoprotein (LDL) cholesterol concentration above 190 mg/dl, regardless of the cause. The majority of patients with FH present mutations in genes controlling LDL concentration, such as genes caused by abnormalities in the LDL receptor protein function and clearance of the LDL particle. The most frequent mutations causing FH are observed in LDLR, ApoB and PCSK9 genes. However, a polygenic origin is also probable in several of FH cases. The marked elevation of plasma LDL cholesterol concentration leads to premature and severe cardiovascular disease, including death, regardless of the gene mutation. Particularly, in individuals with a homozygous form of FH (two identical mutations or compound heterozygotes). Thus, early diagnosis and treatment of FH is vital, since the risk of premature coronary heart disease is estimated to be approximately 20-fold higher in untreated FH patients compared with control subjects. On the contrary, the aggressive lowering of plasma LDL cholesterol concentration decreased the cardiovascular events. A hypolipidemic diet and lipid lowering drugs are the first steps in the treatment of FH patients. The most severe and resistant FH cases are treated with LDL apheresis on top of combined drug therapy. Consequently, the combination of classical hypolipidemic drugs and newly introduced medications, such as PCSK9 inhibitors, antisense oligonucleotide against APOB-100 (mipomersen) and microsomal triglyceride transfer protein inhibitors (lomitapide) provide a way for most FH patients to achieve LDL cholesterol treatment goals.

The World Machine is the second volume Piero Boitani devotes to the way in which the sciences and the arts interact when it comes to modern consideration of the stars and the cosmos (the first, also published in English by Nova Science Publishers, is entitled Looking Upwards: Stars in Ancient and Medieval Cultures). This is not a history of astronomy or astrophysics, but the story arranged in chronological order of how humans have reacted to fundamental changes in astronomy by means of poetry, narrative, painting, architecture, and music over the last five hundred years. This time, the story is basically European (and American), as all the relevant scientific discoveries were made in Europe, and it is the European imaginaire that dominates world culture (non-European images of the universe are dealt with in Looking Upwards). The historical development of this image and of the ideas that contribute to its formation is rather complex and diversified, but two major turning points are clearly identifiable one lies between the sixteenth and seventeenth century, and one at the very beginning of the twentieth century. Concerning the former, the observation of the sky was revolutionized by the telescope. Galileo, Kepler and Newton could thus base their new models of the universe on much more precise experiences, and mathematics became the new language of astronomy. The cosmos increasingly tended to be viewed as a machine, a mechanism like a clock (hence the books title). Between the end of the nineteenth and the beginning of the twentieth century the second scientific revolution took place. The instruments became so refined that they began to detect increasingly remote objects, and the phenomena found in the sky, as well as their behavior, no longer fully responded to Newtonian laws. New theories relativity and quantum mechanics were elaborated, the mathematics needed for them becoming much more difficult for the layman, and the whole structure of matter, with the discovery of the atom, its constituent parts, and its particles was gradually uncovered. Things reached a critical moment with Heisenbergs and Hubbles formulation of, respectively, the uncertainty principle and of the increasing speed at which galaxies recede from us the further they are and finally with the conflict between relativity and quantum theories. Some recent poets (notably in South America) and many painters and musicians in Europe and North America have tried to describe this new cosmos, but the same happened after the first scientific revolution. In short, The Machine of the World recounts an exciting adventure whose protagonists are the likes of Tasso and Milton, Goethe and Wallace Stevens, Canaletto and Friedrich, Verdi and Puccini, Van Gogh and Schoenberg, Joyce and Thomas Mann.