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On November 9-10, 1998, the Forum on Adolescence of the Board on Children, Youth, and Families, a cross-cutting initiative of the Institute of Medicine and the National Research Council of the National Academy of Sciences, convened a workshop entitled Research to Improve Intergroup Relations Among Youth. Held at the request of the Carnegie Corporation of New York, this workshop considered selected findings of 16 research projects that have focused on intergroup relations among children and adolescents; all 16 received funding from Carnegie Corporation of New York for their work on this issue. The funding of these projects was part of a larger research initiative supported by Carnegie Corporation of New York that sought to update and expand the knowledge, sources, and dynamics of racial and ethnic prejudice among youth, identifying approaches to foster intergroup understanding. Improving Intergroup Relations Among Youth is the summary of the workshop, which provided an opportunity to learn about the work and preliminary findings of the 16 projects. This report reviews the knowledge base regarding the effectiveness of interventions designed to promote peaceful, respectful relations among youth of different ethnic groups.

This report assesses the operational performance of explosives-detection equipment and hardened unit-loading devices (HULDs) in airports and compares their operational performance to their laboratory performance, with a focus on improving aviation security.

More than 200,000 U.S. military personnel participated in atmospheric nuclear weapons tests between 1945 and the 1963 Limited Nuclear Test Ban Treaty. Questions persist, such as whether that test participation is associated with the timing and causes of death among those individuals. This is the report of a mortality study of the approximately 70,000 soldiers, sailors, and airmen who participated in at least one of five selected U.S. nuclear weapons test series1 in the 1950s and nearly 65,000 comparable nonparticipants, the referents. The investigation described in this report, based on more than 5 million person-years of mortality follow-up, represents one of the largest cohort studies of military veterans ever conducted.

Issues involving science, technology, and health (STH) have moved to the forefront of the international diplomatic agenda. Other vital issues linked to technological developments pervade longer-range foreign policy concerns. Thus, STH considerations are often central to the Department of State's bilateral and multilateral interactions with other governments. STH aspects play a large role in discussions of such critical topics as nuclear nonproliferation, use of outer space, population growth, adequate and safe food supply, climate change, infectious diseases, energy resources, and competitiveness of industrial technologies. In addressing these issues, expert STH knowledge is essential to the anticipation and resolution of problems and to the achievement of foreign policy goals. The Department, recognizing that it requires strengthened capabilities to address such an array of topics, asked for suggestions by the National Research Council as to how it could better deal with foreign policy issues with STH content.

The Global Energy and Water Cycle Experiment (GEWEX) Panel of the National Research Council (NRC) was tasked by the U.S. Global Change Research Program (USGCRP) to provide a rapid and succinct assessment to relevant agencies on the general merit of the GEWEX America Prediction Project (GAPP), as well as the Coordinated Enhanced Observing Period (CEOP). In addition, the panel was asked to provide guidance to the agencies on the relationships between the agencies' newly proposed hydrologic research activities, GAPP, and CEOP. Providing this guidance is critical, in part, because the federal agencies tend to have somewhat differing priorities across the wide span of GEWEX activities.

In an effort to increase knowledge and understanding of the process of assuring data quality and validity in clinical trials, the IOM hosted a workshop to open a dialogue on the process to identify and discuss issues of mutual concern among industry, regulators, payers, and consumers. The presenters and panelists together developed strategies that could be used to address the issues that were identified. This IOM report of the workshop summarizes the present status and highlights possible strategies for making improvements to the education of interested and affected parties as well as facilitating future planning.

Since the 1970s, concerns about health hazards associated with electric and magnetic fields from power lines and from workplace, school, and household use of electricity have led to many studies and continued controversy about whether adverse health effects occur. In the Energy Policy Act of 1992 (Public Law 102-486), Congress authorized a focused national research program to study the possible health effects of exposure to low-intensity, 60-hertz electric and magnetic fields. In response to this legislation and at the request of the Department of Energy (DOE), the National Research Council established a committee under the Board on Radiation Effects Research (BRER) in the Commission on Life Sciences (CLS) to aid in its review of the power-frequency magnetic field research activities completed under the Electric and Magnetic Fields Research and Public Information Dissemination (EMF-RAPID) program that was authorized by the Energy Policy Act. The Research Council's Committee to Review the Research Activities Completed Under the Energy Policy Act of 1992 (EPACT) was asked to review the EMF-RAPID program implemented by DOE and the National Institute of Environmental Health Sciences (NIEHS), and research strategies suggested by other federal and nonfederal groups.

To explore the connections between new approaches to science education and new developments in assessment, the Board on Testing and Assessment (BOTA) of the National Research Council (NRC) sponsored a two-day conference on February 22 and 23, 1997. Participants included BOTA members, other measurement experts, and educators and policymakers concerned with science education reform. The conference encouraged the exchange of ideas between those with measurement expertise and those with creative approaches to instruction and assessment.

Advances in the capabilities of technologies applicable to distributed networking, telecommunications, multi-user computer applications, and interactive virtual reality are creating opportunities for users in the same or separate locations to engage in interdependent, cooperative activities using a common computer-based environment. These capabilities have given rise to relatively new interdisciplinary efforts to unite the interests of mission-oriented communities with those of the computer and social science communities to create integrated, tool-oriented computation and communication systems. These systems can enable teams in widespread locations to collaborate using the newest instruments and computing resources. The benefits are many. For example, a new paradigm for intimate collaboration between scientists and engineers is emerging. This collaboration has the potential to accelerate the development and dissemination of knowledge and optimize the use of instruments and facilities, while minimizing the time between the discovery and application of new technologies. Advanced Engineering Environments: Achieving the Vision, Phase 1 describes the benefits and feasibility of ongoing efforts to develop and apply advanced engineering environments (AEEs), which are defined as particular implementations of computational and communications systems that create integrated virtual and/or distributed environments linking researchers, technologists, designers, manufacturers, suppliers, and customers.

A major goal of the Federal Aviation Administration (FAA), and now the Transportation Security Administration (TSA), is the development of technologies for detecting explosives and illegal drugs in freight cargo and passenger luggage. One such technology is pulsed fast neutron analysis (PFNA). This technology is based on detection of signature radiation (gamma rays) induced in material scanned by a beam of neutrons. While PFNA may have the potential to meet TSA goals, it has many limitations. Because of these issues, the government asked the National Research Council to evaluate the potential of PFNA for airport use and compare it with current and future x-ray technology. The results of this survey are presented in "Assessment of the Practicality of Pulsed Fast Neutron Analysis for Aviation Security." A broad range of detection methods and test results are covered in this report. Tests conducted as of October 2000 showed that the PFNA system was unable to meet the stringent federal aviation requirements for explosive detection in air cargo containers. PFNA systems did, however, demonstrate some superior characteristics compared to existing x-ray systems in detecting explosives in cargo containers, though neither system performed entirely satisfactorily. Substantial improvements are needed in the PFNA detection algorithms to allow it to meet aviation detection standards for explosives in cargo and passenger baggage. The PFNA system currently requires a long scan time (an average of 90 minutes per container in the prototype testing in October 2000), needs considerable radiation shielding, is significantly larger than current x-ray systems, and has high implementation costs. These factors are likely to limit installation at airports, even if the detection capability is improved. Nevertheless, because PFNA has the best potential of any known technology for detecting explosives in cargo and luggage, this book discusses how continued research to improve detection capabilities and system design can best be applied for the airport environment.

In 1996, NATO issued guidance for the exposure of military personnel to radiation doses different from occupational dose levels, but not high enough to cause acute health effects-and in doing so set policy in a new arena. Scientific and technological developments now permit small groups or individuals to use, or threaten to use, destructive devices (nuclear, biological, chemical, and cyber-based weaponry, among others) targeted anywhere in the world. Political developments, such as the loss of political balance once afforded by competing superpowers, have increased the focus on regional and subregional disputes. What doctrine should guide decisionmaking regarding the potential exposure of troops to radiation in this changed theater of military operations? In 1995, the Office of the U.S. Army Surgeon General asked the Medical Follow-up Agency of the Institute of Medicine to provide advice. This report is the final product of the Committee on Battlefield Radiation Exposure Criteria convened for that purpose. In its 1997 interim report, Evaluation of Radiation Exposure Guidance for Military Operations, the committee addressed the technical aspects of the NATO directive. In this final report, the committee reiterates that discussion and places it in an ethical context.

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "e;the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced."e; On March 26, 1998, AAVS submitted a second petition, stating that "e;NIH failed to provide valid scientific reasons for not supporting a proposed ban."e; The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb.In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method.The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Now that the initial results of The Third International Mathematics and Science Study (TIMSS) have been released, the Board on International Comparative Studies in Education (BICSE) has turned its attention to what happens next. The TIMSS data are potentially useful to researchers, policy makers, practitioners, and others interested in evidence regarding factors that influence student learning. But although the study has produced a remarkable volume of intriguing data, it is by no means complete. Scholarly review of the initial data, evaluations of claims based on the data, and follow-up secondary analysis based on the primary findings are all integral parts of a study of this magnitude, but the bulk of this very important work has not yet begun. Because of the board's serious concern that this necessary work has not been undertaken, or funded, it held a workshop on June 17 and 18, 1998, to explore different perspectives on possible next steps. The workshop was an invaluable opportunity for the board to explore issues and questions it has addressed over the years and to solidify its thinking about many of them. Because the board is convinced of the importance of moving forward with the TIMSS data, it presents in this report both recommendations as to what ought to be done and many of the innovative specific ideas that emerged from the workshop. These recommendations reflect the board's conviction, based on its many years of involvement with and deliberations about TIMSS, that this study is an extremely rich resource for the policy, scholarly, and practice communities, and that all of these groups have a responsibility to take full advantage of it. The recommendations and discussion in this report are intended to assist both researchers and funders who are considering further work with TIMSS, and a broader audience of researchers, policy makers, practitioners, and others who have followed the TIMSS results and are eager to use them. This report is, in a sense, the culmination of many years of effort for the board.

The National Roundtable on Health Care Quality was established in 1995 by the Institute of Medicine. The Roundtable consists of experts formally appointed through procedures of the National Research Council (NRC) who represent both public and private-sector perspectives and appropriate areas of substantive expertise (not organizations). From the public sector, heads of appropriate Federal agencies serve. It offers a unique, nonadversarial environment to explore ongoing rapid changes in the medical marketplace and the implications of these changes for the quality of health and health care in this nation. The Roundtable has a liaison panel focused on quality of care in managed care organizations. The Roundtable convenes nationally prominent representatives of the private and public sector (regional, state and federal), academia, patients, and the health media to analyze unfolding issues concerning quality, to hold workshops and commission papers on significant topics, and when appropriate, to produce periodic statements for the nation on quality of care matters. By providing a structured opportunity for regular communication and interaction, the Roundtable fosters candid discussion among individuals who represent various sides of a given issue.

The 1997 Conference on the World Climate Research Programme to the Third Conference of the Parties of the United Nations Framework Convention on Climate Change concluded that the global capacity to observe the Earth's climate system is inadequate and is deteriorating worldwide. As a result, the chair of the subcommittee of the U.S. Global Change Research Program (USGCRP) requested a National Research Council study to assess the current status of the climate observing capabilities of the United States. This report focuses on existing observing systems for detection and attribution of climate change, with special emphasis on those systems with long time series.

We in the United States have almost come to accept natural disasters as part of our nation's social fabric. News of property damage, economic and social disruption, and injuries follow earthquakes, fires, floods and hurricanes. Surprisingly, however, the total losses that follow these natural disasters are not consistently calculated. We have no formal system in either the public or private sector for compiling this information. The National Academies recommends what types of data should be assembled and tracked.

There has been intense interest recently among the public and the media in the possibility that increased intakes of "dietary antioxidants" may protect against chronic disease. Many research programs are underway in this area. Epidemiological evidence suggests that the consumption of fruits and vegetables may reduce the risk of both cancer and cardiovascular disease, and it has been hypothesized that this is due in part to the presence of antioxidant compounds in fruits and vegetables. As a result, these compounds have been considered together by many people and loosely termed dietary antioxidants. Closer examination, however, reveals that compounds typically grouped together as dietary antioxidants can differ quite considerably from one another, both in terms of their chemical behavior and in terms of their biological properties. This report from the Institute of Medicine's Food and Nutrition Board provides a proposed definition of dietary antioxidants so as to characterize the biological properties of these compounds.

Losses of life and property in the United States-and throughout the world-resulting from hydrologic hazards, including floods, droughts, and related phenomena, are significant and increasing. Public awareness of, and federal attention to, natural disaster reduction, with a focus on mitigation or preparedness so as to minimize the impacts of such events, have probably never been greater than at present. With over three-quarters of federal disaster declarations resulting from water-related events, national interest in having the best-possible hydrologic data, information, and knowledge as the basis for assessment and reduction of risks from hydrologic hazards is clear.The U.S. Geological Survey (USGS) plays a variety of unique and critical roles relevant to hydrologic hazard understanding, preparedness, and response. The agency's data collection, research, techniques development, and interpretive studies provide the essential bases for national, state, and local hydrologic hazard risk assessment and reduction efforts. This work includes some of the more traditional activities of the Water Resources Division (e.g., streamflow measurement) and some of the more innovative interdisciplinary activities (e.g., hydrologic research, educational outreach, real-time data transmission, and risk communication) being pursued in cooperation with other divisions of the USGS, other federal and state agencies, and other local entities. This report aims to help shape a strategy and improve the overall framework of USGS efforts in these important areas.

This study was undertaken in recognition of the critical role played by the Energy Resources Program (ERP) of the U.S. Geological Survey (USGS) in the energy future of the United States. The ERP performs fundamental research to understand the origin and recoverability of fossil energy resources and conducts assessments of their future availability. The ERP also provides information and expertise on environmental effects.

The US Environmental Protection Agency Office of Radiation and Indoor Air asked the National Research Council to evaluate whether sufficient new data exist to warrant a reassessment of health risks reported in Health Effects of Exposure to Low Levels of Ionizing Radiations (BEIR V) in 1990. To respond to this request, the National Research Council assembled the Committee on Health Risks of Exposure to Low Levels of Ionizing Radiations. The work of the committee was conducted in what was called the BEIR VII phase-1 study. To assist the committee during its deliberations, various scientists were consulted for advice, and a workshop on the impact of biology on risk assessment was held in collaboration with the Department of Energy Office of Health and Environmental Research. The intent of the workshop was to address the implications of new understanding of the biologic basis of radiation injury and carcinogenesis for risk assessment.

As part of the national effort to improve aviation safety, the Federal Aviation Administration (FAA) chartered the National Research Council to examine and recommend improvements in the aircraft certification process currently used by the FAA, manufacturers, and operators.

The MSEB, with generous support and encouragement from the Carnegie Corporation of New York, seeks to bring discussion of assessment to school-and district-based practitioners through an initiative called Assessment in Practice (AIP). Originally conceived as a series of "e;next steps"e; to follow the publication of Measuring Up and For Good Measure, the project, with assistance from an advisory board, developed a publication agenda to provide support to teachers and others directly involved with the teaching and assessment of children in mathematics classrooms at the elementary, middle, and high school levels.In a series of three booklets, AIP presents an exploration of issues in assessment. The first booklet, Learning About Assessment, Learning Through Assessment discusses ways to assist teachers in learning about assessment and how student work can be a rich resource in professional development. The second, Assessment in Support of Instruction, makes a case for aligning assessments with state and district curriculum frameworks and examines ways in which states have shifted their curriculum frameworks and related state assessment programs to reflect the NCTM Standards and other perspectives. The third booklet, Keeping Score, discusses issues to be considered while developing high quality mathematics assessments. This series is specifically designed to be used at the school and school district level by teachers, principals, supervisors, and measurement specialists.

The colloquium on "Imaging of Cognitive Function" speaks to the many audiences whose interests relate to efforts to map cognitive processes in the human brain. There are things of great interest in this collection of papers for specialists in cognition and neuroscience and imaging science as well as in disciplines interested in human development through education and training and others with intrinsic interest in the latest information on how the human brain supports thought. The papers were presented at a meeting sponsored by the National Academy of Sciences in its western home the Beckman Center at the University of California, Irvine.

As populations throughout the world live longer, there is an increasing trend toward global commonality of health concerns. This trend mirrors a growing demand for health and access to new interventions to prevent, diagnose, and treat disease. The knowledge base required to meet these needs is not only of a technical kind, deriving from experiments of researchers, but must also draw from the experiences of governments in allocating resources effectively and efficiently to improve human health. This report from the Board on International Health of the Institute of Medicine focuses on the interest of the United States in these global health transitions. The report argues that America has a vital and direct stake in the health of people around the globe, and that this interest derives from both America's long and enduring tradition of humanitarian concern and compelling reasons of enlightened self-interest.