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This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).

This Special Issue, "Approaches in Enhancing Antioxidant Defense in Plants" published 13 original research works and a couple of review articles that discuss the various aspects of plant oxidative stress biology and ROS metabolism, as well as the physiological mechanisms and approaches to enhancing antioxidant defense and mitigating oxidative stress. These papers will serve as a foundation for plant oxidative stress tolerance and, in the long term, provide further research directions in the development of crop plants' tolerance to abiotic stress in the era of climate change.

The high importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted considerable interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment, suitably designed to be a similar as possible to cellular conditions.This Special Issue provides readers with a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to be used as traces for the discoveries of some relevant biological processes. Several subjects are presented, with five articles and five reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications and bioinspired synthesis, with "free radicals" as the common denominator.

Even if the terms "forensic sciences" and "legal medicine" seem to be synonymous, they could be defined as two sides of the same coin. It has been demonstrated that they are different components of the application of medical knowledge upon the legal system. Legal medicine has greater relevance to civil and tort law, impacting upon patient care, whereas forensic medicine relates to criminal law and damage to (or by) patients. This Special Issue, entitled "Forensic Science and Legal Medicine: A Multidisciplinary Puzzle!", collected accurate and up-to-date scientific information on all aspects of this theme, publishing original investigations, case series and case reports, and reviews in all forensic and medico-legal branches.

Neuroactive chemicals are the largest group of micropollutants present in European rivers. There is increasing concern about the behavioral effects of these neuroactive chemicals on aquatic wildlife, potentially resulting in detrimental effects on individual, population, and community levels of ecological organization. This Special Issue, titled "Behavioral Impairment in Aquatic Organisms Exposed to Neurotoxic Pollutants", presents original research and review articles addressing behavioral impairment induced by different aquatic invertebrate and vertebrate species to neuroactive chemicals. The selected studies include different methodological approaches, such as multi-compartment, automated plug and play, and homemade setups systems. We believe that this collection provides essential information regarding research and challenges on the behavioral ecotoxicity of invertebrate and vertebrate aquatic organisms, as well as the molecular mechanisms behind these effects.

An outstanding compilation that reflects the state-of-the art on Dielectrophoresis (DEP) in 2020. Contributions include: - A novel mathematical framework to analyze particle dynamics inside a circular arc microchannel using computational modeling. - A fundamental study of the passive focusing of particles in ratchet microchannels using direct-current DEP. - A novel molecular version of the Clausius-Mossotti factor that bridges the gap between theory and experiments in DEP of proteins. - The use of titanium electrodes to rapidly enrich T. brucei parasites towards a diagnostic assay. - Leveraging induced-charge electrophoresis (ICEP) to control the direction and speed of Janus particles. - An integrated device for the isolation, retrieval, and off-chip recovery of single cells. - Feasibility of using well-established CMOS processes to fabricate DEP devices. - The use of an exponential function to drive electrowetting displays to reduce flicker and improve the static display performance. - A novel waveform to drive electrophoretic displays with improved display quality and reduced flicker intensity. - Review of how combining electrode structures, single or multiple field magnitudes and/or frequencies, as well as variations in the media suspending the particles can improve the sensitivity of DEP-based particle separations. - Improvement of dielectrophoretic particle chromatography (DPC) of latex particles by exploiting differences in both their DEP mobility and their crossover frequencies.

This Special Issue is dedicated to sustainable mobility and transport, with a special focus on technological advancements. Global transport systems are significant sources of air, land, and water emissions. A key motivator for this Special Issue was the diversity and complexity of mitigating transport emissions and industry adaptions towards increasingly stricter regulation. Originally, the Special Issue called for papers devoted to all forms of mobility and transports. The papers published in this Special Issue cover a wide range of topics, aiming to increase understanding of the impacts and effects of mobility and transport in working towards sustainability, where most studies place technological innovations at the heart of the matter. The goal of the Special Issue is to present research that focuses, on the one hand, on the challenges and obstacles on a system-level decision making of clean mobility, and on the other, on indirect effects caused by these changes.

This reprint contains 11 chapters on a wide range of subjects related to the impacts of different types of epidemics on our ability to practice personalized medicine. Together, these chapters provide a broad overview with many different examples of epidemics. The personalization of medicine is present both despite and because of epidemics. Many more examples are possible, but this reprint offers a primary overview emphasizing the widely spread relevance of the topic.

Temporomandibular Joint Diseases are common and dificult to treat. From diagnosis to treatment, our options are in a broad range. Keeping updated with new technologies is extremely important for researchers and health professionals.

Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, rendering oncology well along the path to "personalised cancer medicine". Thanks to developments in genetics, several mutations and gene rearrangements have been identified in patients with endocrine cancers (e.g., thyroid and adrenocortical carcinoma). In particular, each patient can be considered as a unique, individual one, with unique genetic information. The aim of this Special Issue is to offer an overview of exciting new research in the area of endocrine tumours may set the stage for an innovative personalised management and precision medicine modalities for individualised care.

Interest has grown regarding natural plant extracts in food and beverage applications, their vital role in the food industry, and their therapeutic use against diseases. The protective effects of healthy diets are partially due to the variety of plant metabolites, particularly phenolic compounds, which are considered the most important class of compounds that originates from plant-derived metabolites. Phenolics are well renowned for their possession of a wide array of remarkable biological properties. This Special Issue (SI) aims to gather the most recent contributions concerning their chemistry, extraction methods, and analytical techniques, applications, and biological activities. This Special Issue of Processes, entitled "Phenolic Compounds: Extraction, Optimization, Identification and Applications in Food Industry", gathers the recent work of leading researchers in a single collection, covering a variety of theoretical studies and experimental applications and focusing on the extraction, identification, and industrial applications. The advances presented in the contributions in this SI have significantly helped to accomplish this target. In addition to research articles, the Special Issue features two reviews that cover a range of topics highlighting the versatility of the area. The topics covered in this SI include advanced methodologies for the isolation, purification, and analysis of phenolics from food, food waste, and medicinal plants; biological activities and mechanisms of action; health benefits from in vivo evaluation; and the development of novel phenolics-based nutraceuticals and functional ingredients.

Data Science (DS) is gaining significant importance in the decision process due to a mix of various areas, including Computer Science, Machine Learning, Math and Statistics, domain/business knowledge, software development, and traditional research. In the business field, DS's application allows using scientific methods, processes, algorithms, and systems to extract knowledge and insights from structured and unstructured data to support the decision process. After collecting the data, it is crucial to discover the knowledge. In this step, Knowledge Discovery (KD) tasks are used to create knowledge from structured and unstructured sources (e.g., text, data, and images). The output needs to be in a readable and interpretable format. It must represent knowledge in a manner that facilitates inferencing. KD is applied in several areas, such as education, health, accounting, energy, and public administration. This book includes fourteen excellent articles which discuss this trending topic and present innovative solutions to show the importance of Data Science and Knowledge Discovery to researchers, managers, industry, society, and other communities. The chapters address several topics like Data mining, Deep Learning, Data Visualization and Analytics, Semantic data, Geospatial and Spatio-Temporal Data, Data Augmentation and Text Mining.

In a VUCA world (volatile, uncertain, complex, and ambiguous), organizations, in order to achieve a sustainable competitive advantage, must learn to mitigate risk and prioritize performance and innovation. In the last decade, as a way to respond to market demands, projects emerge as a way for organizations to implement their strategic objectives in order to respond to a need, opportunity, or threat in an efficient way. This e-book includes a collection of 11 papers that discuss theoretical approaches and case studies, focused on a combined effect between Project Risk Assessment and corporate behaviour in order to support the sustainability and business resilience in a competitive environment. The e-book will be of particular interest to entrepreneurs, researchers, and policymakers.

The climate changes that are becoming visible today are a challenge for the global research community. In this context, renewable energy sources, fuel cell systems and other energy generating sources must be optimally combined and connected to the grid system using advanced energy transaction methods. As this reprint presents the latest solutions in the implementation of fuel cell and renewable energy in mobile and stationary applications such as hybrid and microgrid power systems based on the Energy Internet, blockchain technology and smart contracts, we hope that they will be of interest to readers working in the related fields mentioned above.

Biomaterials-the materials used for the manufacturing of medical devices- are part of everyday life. Each one of us has likely had the experience of visting a dentist's office, where a number of biomaterials are used temporarily or permanently in the mouth. Devices that are more complex are used for to support, heal, or replace living tissues or organs in the body that are suffering or compromised by different conditions. The materials used in their construction are metals and metallic alloys, polymers-ranging from elastomers to adhesives-and ceramics.Within these three cases, there are materials that are inert in the living environment, that perform an active function, or that are dissolved and resorbed by the metabolic pathways. Biomaterials are the outcome of a dynamic field of research that is driven by a growing demand and by the competition among the manufacturers of medical devices, with innovations improving the performance of existing devices and that contribute to the development of new ones. The collection of papers forming this volume have one particular class of of biomaterial in common, ceramic (bioceramic) composites, which as so far been used in applications such as orthopaedic joint replacement as well as in dental implants and restorations and that is being intensively investigated for bone regeneration applications. Today's bioceramic composites (alumina-zirconia) are the golden standard in joint replacements. Several manufracturers have proposed different zirconia-alumina composites for use in hip, knee, and shoulder joint replacements, with several other innovative devices also being under study. In addition, bioceramic composites with innovative compositions are under development and will be on the market in years to come. Something that is especially interesting is the application of bioceramic composites in the regeneration of bone tissues. Research has devoted special attention to the doping of well-known materials (i.e., calcium phosphates and silicates) with bioactive ions, aiming to enhance the osteogenic ability and bioresorbability of man-made grafts. Moreover, high expectations rely on hybrid biopolymer/ceramic materials that mimic the complex composition and multiscale structure of bone tissue.

Exceptional design loads on buildings and structures may have different causes, including high-strain natural hazards, man-made attacks and accidents, and extreme operational conditions. All of these aspects can be critical for specific structural typologies and/or materials that are particularly sensitive. Dedicated and refined methods are thus required for design, analysis, and maintenance under structures' expected lifetimes. Major challenges are related to the structural typology and material properties. Further issues are related to the need for the mitigation or retrofitting of existing structures, or from the optimal and safe design of innovative materials/systems. Finally, in some cases, no design recommendations are available, and thus experimental investigations can have a key role in the overall process. For this SI, we have invited scientists to focus on the recent advancements and trends in the sustainable design of high-performance buildings and structures. Special attention has been given to materials and systems, but also to buildings and infrastructures that can be subjected to extreme design loads. This can be the case of exceptional natural events or unfavorable ambient conditions. The assessment of hazard and risk associated with structures and civil infrastructure systems is important for the preservation and protection of built environments. New procedures, methods, and more precise rules for safety design and the protection of sustainable structures are, however, needed.

Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a "stand alone" analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications.

This book focuses on the use of GIScience in conjunction with historical visual sources to resolve past scenarios. The themes, knowledge gained and methodologies conducted might be of interest to a variety of scholars from the social science and humanities disciplines.