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There are many different types of cancer. Some are very common; others are rare. Having some similar features, each cancer has its own characteristics and symptoms, which vary according to the type of cancer and where it is in the body. The treatment selected may be influenced by the patient's age, concurrent health problems, life expectancy, characteristics of the individual's cancer, the patient's goals of treatment, and the bias of the treating physician. In preparing this book, we have considered and reflected on the concept of the recent advances in cancer management and therapy as well as molecular applications in cancer therapy. The readers can find detailed information about the treatment and management of specific cancers in these book chapters.

The worldwide consumption of fossil fuel continues to increase at unsustainable levels, which will lead to progressive scarcity, if immediate and innovative measures are not taken for its sustainable use. This scarcity necessitates the development of renewable and sustainable alternatives for fossil fuels. A possible solution to today's energy challenges can be provided by biofuels. This book intends to provide the reader with a comprehensive overview of the current status and the future implications of biofuels. Diverse and aptly covered comprehensive information in this book will directly enhance both basic and applied research in biofuels and will particularly be useful for students, scientists, breeders, growers, ecologists, industrialists and policy makers. It will be a valuable reference point to improve biofuels in the areas of ecologically and economically sustainable bioenergy research.

The use of copper, silver, gold and platinum in jewelry as a measure of wealth is well known. This book contains 19 chapters written by international authors on other uses and applications of noble and precious metals (copper, silver, gold, platinum, palladium, iridium, osmium, rhodium, ruthenium, and rhenium). The topics covered include surface-enhanced Raman scattering, quantum dots, synthesis and properties of nanostructures, and its applications in the diverse fields such as high-tech engineering, nanotechnology, catalysis, and biomedical applications. The basis for these applications is their high-free electron concentrations combined with high-temperature stability and corrosion resistance and methods developed for synthesizing nanostructures. Recent developments in all these areas with up-to-date references are emphasized.

Space has always been intriguing people's imagination. However, space flight has only been feasible over the last 60 years. The collective effort of distinguished international researchers, within the field of space flight, has been incorporated into this book suitable to the broader audience. The book has been edited by Prof. George Dekoulis, Aerospace Engineering Institute (AEI), Cyprus, an expert on the state-of-the-art implementations of reconfigurable space physics systems. The book consists of six sections, namely, "Introduction," "Spacecraft Simulators," "Spacecraft Navigation," "Spacecraft Propulsion," "Suborbital Flight," and "Deep-Space Flight." We hope that this book will be beneficial for professionals, researchers, and academicians and inspires the younger generations into pursuing relevant academic studies and professional careers within the space industry.

For thousands of years, cataract surgery continues to be the "pearl" of ophthalmic surgery. It is explained by the fact that cataract removal always leads to an increase in visual acuity of patients. A new technology of cataract removal, phacoemulsification, was introduced by Charles Kelman in 1967. Despite this, it was difficult for the surgeons to transform from extracapsular cataract extraction to the new method - phacoemulsification. Recently, in the ophthalmological practice, the method of femtolaser cataract surgery (FLACS) has been introduced. This method allows you to automatically perform the basic stages of cataract surgery - corneal incisions, capsulorhexis, nucleus fracture. At the same time, to apply the various techniques of cataract surgery, the surgeon must possess virtually all the necessary techniques. This is dictated by the fact that, as a rule, cataract itself is rarely isolated - senile. Knowledge of the basic rules of cataract surgery, the use of pupillary rings and iris retractors in narrow pupils, the use of capsular rings in subluxations of the lens, the use of special modes of phaco in severe late cataracts, and a comprehensive clinical way of thinking can undoubtedly reduce the complications of cataract surgery.

Bismuth (Bi) is a post-transition metal element with the atomic number of 83, which belongs to the pnictogen group elements in Period 6 in the elemental periodic table. As a heavy metal, the hazard of Bi is unusually low in contrast to its neighbors Pb and Sb. This property, along with other typical characteristics like strong diamagnetism and low thermal conductivity, makes Bi attractive in industrial applications. There are more than 100 commercial bismuth products, from pharmaceutical to industrial catalysts. Based on the wide applications of Bi materials, this book goes further and mainly focuses on the potential uses of Bi-based materials, which consist of nine chapters. In addition, a special chapter concerning the defect in bismuth is also presented.

Our anatomy and physiology have been completely shaped by Earth's gravity. All body systems function in synergy with this unseen force. Yet, as we journey further and longer into space, our bodies must conform to a new reality, wherein gravity is absent or reduced, cosmic radiation threatens and our social and familial connections become distant. Into Space: A Journey of How Humans Adapt and Live in Microgravity gives an overview of some of the physiological, anatomical and cellular changes that occur in space and their effects on different body systems, such as the cardiovascular and musculoskeletal, and touches on cultural and psychosocial aspects of leaving behind family and the safety of Earth. It further addresses the complexity of manned space flights, showing how interdisciplinary this subject is and discussing the challenges that space physiologists, physicians and scientists must face as humans seek to conquer the final frontier.

Goat science covers quite a wide range and varieties of topics, from genetics and breeding, via nutrition, production systems, reproduction, milk and meat production, animal health and parasitism, etc., up to the effects of goat products on human health. In this book, several parts of them are presented within 18 different chapters. Molecular genetics and genetic improvement of goats are the new approaches of goat development. Several factors affect the passage rate of digesta in goats, but for diet properties, goats are similar to other ruminants. Iodine deficiency in goats could be dangerous. Assisted reproduction techniques have similar importance in goats like in other ruminants. Milk and meat production traits of goats are almost equally important and have significant positive impacts on human health. Many factors affect the health of goats, heat stress being of increasing importance. Production systems could modify all of the abovementioned characteristics of goats.

Corticosteroids are mainly used to reduce inflammation and suppress the immune system. Corticosteroids will only be prescribed if the potential benefits of treatment outweigh the risks. They will also be prescribed at the lowest effective dose for the shortest possible time. This book will strive to highlight the importance of corticosteroids, to focus on minimizing side effects, to monitor and sensitize the population on the potential adverse effects of misuse, to provide additional knowledge about the design and development of new drug delivery systems loaded with corticosteroids potentially useful in the treatment of chronic inflammatory-based diseases, and to reduce inflammation and affect the immune system. The major objective of this book will be to present the information in a lucid, condensed, and cohesive form and to specially cater to the needs of readers in medicine and pharmacy.

The editor has incorporated contributions from a diverse group of leading researchers in the field of differential equations. This book aims to provide an overview of the current knowledge in the field of differential equations. The main subject areas are divided into general theory and applications. These include fixed point approach to solution existence of differential equations, existence theory of differential equations of arbitrary order, topological methods in the theory of ordinary differential equations, impulsive fractional differential equations with finite delay and integral boundary conditions, an extension of Massera's theorem for n-dimensional stochastic differential equations, phase portraits of cubic dynamic systems in a Poincare circle, differential equations arising from the three-variable Hermite polynomials and computation of their zeros and reproducing kernel method for differential equations. Applications include local discontinuous Galerkin method for nonlinear Ginzburg-Landau equation, general function method in transport boundary value problems of theory of elasticity and solution of nonlinear partial differential equations by new Laplace variational iteration method. Existence/uniqueness theory of differential equations is presented in this book with applications that will be of benefit to mathematicians, applied mathematicians and researchers in the field. The book is written primarily for those who have some knowledge of differential equations and mathematical analysis. The authors of each section bring a strong emphasis on theoretical foundations to the book.

Arid environments are basically associated with water scarcity. Therefore, soils will have an extremely low moisture level to support plant and animal life as well as human social life. Sustainability is the long durability of systems and processes within various adapted environmental conditions. Recently, systematic scientific studies on arid environments and sustainability have become more attractive, critical, and sound than the previous years. Sharing such experiences related to different environmental circumstances will absolutely help scientists and decision-makers to have better interpretation of their own environment. By learning lessons, appropriate, fast, and effective approaches require to implement for overwhelming such problems. Such actions will certainly lead to more secure and sustainable environments for plant, animal, and human life.

Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.

This book focuses on metagenomics for gut microbiomes. The host is deprived of various benefits derived from the numerous gut microbes for food metabolism and health. However, polysaccharides such as cellulose, xylans, resistant starch, and inulin that are found in vegetables in our diet are digested by certain species that colonize the intestines. In contrast, metagenomic studies that reiterate microbiome intrinsic factors from particular communities and lifestyles and are extremely important for bacterial communities traveling over a long distance have entered a new era. Predominantly to understand the behavior of organisms and their action in a host, next-generation sequencing will provide a new insight into analyzing the livestock industry, agriculture, and human health risks and will consider for future development novel therapies for various diseases through identification of advanced tools. Hence, the book will give more precise information on the role of gut microbiomes in the host.

The book Potassium - Improvement of Quality in Fruits and Vegetables Through Hydroponic Nutrient Management provides useful information regarding potassium nutrition management in hydroponic cultivation, which will help in producing quality horticultural crops. The first few chapters describe the role of potassium nutrition in plants, its interaction with other nutrients, its source fertilizers, the role in postharvest produce qualities, and human nutrition. Potassium fertilizer management, its metabolism in plants, and cultivation techniques of fruits and leafy vegetables are also included in the middle section. The final chapter illustrates the software development for the calculation of hydroponic nutrients including potassium for easy management of cultural solution. As a whole, this book covers several major aspects on the topic for making it a complete and useful resource.

Taxes are a constant part of life for every company and a constant element of economics, finance, and financial law. Any changes observed in the science and theory also apply to the importance and position of taxes in the practice of corporate finance, public finance, and economic growth. Beside this, a new meaning of taxes in the economies of countries in the world and the European Union is introduced. Taxes will always introduce risks and uncertainties in business, due to the high volatility and uncertainty of tax law. Moreover, being a category that affects the economic growth, they cause disturbances in stability and welfare of the state. Therefore, while considering the essence of taxes in a country, one should not consider this category in isolation from corporate finance and social welfare. Two things are certain in the world: death and taxes.

Cotton, a source of natural fiber for textile industry, has a long breeding history aiming at increasing cotton fiber yield and its quality. Newly developed cotton varieties poorly respond in low-input environments. Secondly, the impact of changing climate may threaten the cotton production in the future. To address these challenges, efforts toward the development of resilient cotton varieties have been initiated using genetic and modern genomic approaches. In this book, research updates on cotton fiber types and properties, DNA markers for selecting desirable cotton plants, and cotton fiber genomics were compiled. Also, the modern breeding trends including development of transgenic cotton and the biosafety studies and possibilities of improving cotton genome using modern genome editing tools were also compressively discussed.

The development of diabetic retinopathy is a long slow process affected by hyperglycemia, hypertension, lipid levels and genetics. It is expected that in 20 years' duration nearly all those with diabetes will exhibit diabetic retinopathy. In some patients, it will progress to blindness. While the number of individuals with diabetes increases, our current treatments are only effective at advanced levels of disease. Further, our screening methods to detect those needing treatment are currently not optimal. Early Events in Diabetic Retinopathy and Intervention Strategies covers topics addressing imaging processes currently available in the development of diabetic retinopathy screening. Potential biomarkers, that may be used to identify those at risk and illuminate the new pathways which lead to diabetic retinopathy, are expounded.

Surface waves have drawn a significant attention and interest in the recent years in a broad range of commercial applications, while their commercial developments have been supported by fundamental and applied research studies. This book is a result of contributions of experts from international scientific community working in different aspects of surface waves and reports on the state-of-the-art research and development findings on this topic through original and innovative research studies. It contains up-to-date publications of leading experts, and the edition is intended to furnish valuable recent information to the professionals involved in surface wave analysis and applications. The text is addressed not only to researchers but also to professional engineers, students, and other experts in various disciplines, both academic and industrial, seeking to gain a better understanding of what has been done in the field recently and what kind of open problems are in this area.

This book provides the application of praxises in the field of engineering safety by learning from previous system failures. And it addresses the most recent developments in the theoretical and practical aspects of these important fields, which, due to their special nature, bring together in a systematic way, many disciplines of engineering, from the traditional to the most technologically advanced. The authors of these chapters are involved in using the system thinking and system engineering approaches at the scale of increased complexity and advanced computational solutions to such systems. The chapters cover the areas such as failure assessment in aeronautical engineering, seismic resistance of offshore pipeline engineering, electrical engineering, critical infrastructure failure, and system of system theory.

Nano- and micro-sized natural fibers of vegetable origin are fully biodegradable in nature. However, the nano- and micro-sized synthetic fibers are fully man-made. Fiber-reinforced composites composed of stiffened fiber and matrix are well-known engineering materials. Fiber-reinforced materials have been used in industrial production. Natural fibers can be obtained from many sources in nature such as wool, sisal, ramie, kenaf, jute, hemp, grass, flax, cotton, coir, bamboo and abaca, banana, and sugarcane bagasse. Artificial fibers have been produced from more stiff materials such as glass, single-walled carbon nanotubes, double-walled carbon nanotubes, carbon, aramid, boron and polyethylene (PE). The cyclic reusability of materials is an important qualification in protecting the environment from waste pollution. Three important factors can be mentioned in terms of material properties in the recycling process. The first factor is "the rate of cyclic usage," the second one is "less material loss in each recycle," and the last one is "the role of waste products in the self-renewal of ecosystem." In engineering area, the usage of waste materials has taken into account in production of composite materials. The use of waste materials as particulate-type composite production is also possible in the industry. Fiber-reinforced materials can be grouped into two categories: "the natural fiber-reinforced materials" and "the artificially produced fiber-reinforced materials." Finally, we conclude that this book consists of mainly summarized three subject headings within the two specific book subsections : The first group contains the main subjects related to the natural and artificial fibers obtained by literature review; second, experimental and numerical studies are made in order to perform the necessary arrangements in the production stages and to establish a decision mechanism on the specification of the technical properties of the fiber-reinforced composites. The third group of studies focused on the use of sustainable bio-composites and recycled textile wastes as reinforcements in construction.

Forest management should allow the sustainable use of forests. This is only possible through solid knowledge in the disciplines that forest science encompasses. The readers of New Perspectives in Forest Science have an excellent source of information on actual trends of forest research and knowledge about the use of forest and landscape. This book has been written by specialists focusing on the following aspects of forest science: C cycle, biomass, forest restoration, forest resources and biodiversity. The authors of this book are of different nationalities and specialties, thus providing diverse perspectives on the subject of forestry. We hope that the chapters of this book can serve both students and researchers, as excellent guides to improve their knowledge on forest science.

Autoimmune bullous diseases are a group of rare skin diseases characterized by intraepidermal and subepidermal bullae formations due to autoantibodies directed against the structural proteins of the epidermis or the dermal-epidermal junction. Early and correct diagnosis and adequate treatment of autoimmune bullous diseases are important as they cause morbidity and mortality in the affected patients. This book, which gives detailed information about autoimmune bullous diseases, has two sections and nine chapters with sixteen contributing authors. The first section describes the structure and tasks of desmosomes and basement membrane zone, which consist of the major antigens of skin integrity targeted by autoantibodies. The second section is about the epidemiology, etiopathogenesis, mucocutaneous, histopathologic and laboratory findings, and therapy of autoimmune bullous diseases.

This book gives a wide overview of the state-of-the-art applications of Raman spectroscopy in characterization of materials and biomaterials. The Raman signal is intrinsically smaller than other vibrational techniques; however, mainly through intensification processes, such as resonance Raman (RR) and surface-enhanced Raman spectroscopy (SERS), the Raman cross section can be strongly amplified. Thoroughly in these signal amplifications, the study of a diversity of chemical systems and the use of Raman technique for in situ and in vivo measurements is possible. The main goal of this book is to open up to an extended audience the possibilities of uses of Raman spectroscopy. In fact, this collective work will be beneficial to students, teachers, and researchers of many areas who are interested to expand their knowledge about Raman spectroscopy applied to nanotechnology, biotechnology, environmental science, inorganic chemistry, and health sciences.

This monograph focuses on the level of management culture development in organizations attempting to disclose it not only with the help of theoretical insights but also by the approach based on employees and managers. Why was the term "management culture" that is rarely found in literature selected for the analysis? We are quite often faced with problems of terminology. Especially, it often happens in the translation from one language to another. While preparing this monograph, the authors had a number of questions on how to decouple the management culture from organization's culture and from organizational culture, how to separate management culture from managerial culture, etc. However, having analysed a variety of scientific research, it appeared that there is no need to break down the mentioned cultures because they still overlap. Therefore, it is impossible to completely separate the management culture from the formal or informal part of organizational culture. Management culture inevitably exists in every organization, only its level of development may vary.

Research in the area of bilingualism and multilingualism invariably produces fascinating insights. In the Europe of yesteryears, the paradigm of one nation one language was dominant and fashionable as a nation-building ideology that multilingualism was considered a curse, a demon that had to be exorcised. Today, the avalanche of empirical evidence of research findings has established multilingualism and pluralism as an ideal for national development. The nine chapters of this book provide further elucidations of the issue of benefits of bilingualism and multilingualism and also provide original research findings on developments in the areas of psychological dimensions of bilingualism and bilingualism in information retrieval systems. The book by its illuminating description and insightful analysis of issues of bilingualism will be of significant interest to scholars, researchers, and all concerned with bilingualism and multilingualism from whatever perspective.

Most coveted energy forms nowadays are gas in nature and electricity due to their environmental cleanness and convenience. Recently, gasification market trend is starting to switch to low-grade feedstock such as biomass, wastes, and low-rank coal that are still not properly utilized. In this sense, the most promising area of development in gasification field lies in low-grade feedstock that should be converted to more user-friendly gas or electricity form in utilization. This book tried to shed light on the works on gasification from many parts of the world and thus can feel the technology status and the areas of interest regarding gasification for low-grade feedstock.

This book "Risk Management Treatise for Engineering Practitioners" has been published by academic researchers and experts on risk management concepts mainly in the construction engineering sector. It addresses basic theories and principles of risk management backed up, in most cases, with case studies. The contributions for this book came from authors in Europe, the Far East and Africa, and it is hoped that the contents of this book will be useful to anyone interested in understanding the principles and applications of risk management, especially within the construction engineering sector. Researchers and postgraduate students in science and engineering disciplines, especially those interested in project management, will find this book useful.

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.