Böcker utgivna av Elsevier Science

Artificial intelligence (AI) plays a crucial role in production engineering and management, revolutionizing operation optimization, data analysis, forecasting, and task automation. In production engineering, AI contributes to operational efficiency by identifying patterns, predicting failures, and optimizing supply chains. In management, it offers predictive and prescriptive insights, allowing quick adaptations to changes in market conditions. However, it is essential to address ethical challenges, such as data security and workforce impacts, to ensure responsible and sustainable implementation of AI in these contexts. Among the different topics covered in Artificial Intelligence in Production Engineering and Management, the reader can find, among others, living under AI; machine learning and large language models; AI and people management; nudging financial behavior in AI; the European Union narrative on AI; multidimensional transhuman influence; and AI, emotional intelligence, and ethics. This topical book will be of great value for those working and researching in the production engineering and management fields who are seeking to understand and capitalize on the revolutionary wave that artificial intelligence brings to modern engineering and management.

Bioinformatics for Everyone provides a brief overview on currently used technologies in the field of bioinformatics¿interpreted as the application of information science to biology¿ including various online and offline bioinformatics tools and softwares. The book presents valuable knowledge in a simplified way to help students and researchers easily apply bioinformatics tools and approaches to their research and lab routines. Several protocols and case studies that can be reproduced by readers to suit their needs are also included.

Parkinson¿s Disease Therapeutics: Emphasis on Nanotechnological Advances presents the latest information on the second most common neurodegenerative disorder in the elderly. Despite remarkable progress in various PD therapeutics, such as microRNAs and brain drug delivery systems, a few limitations impede their success. This book sheds light on the pros and cons of recently developed novel therapeutics. Very few books have highlighted the protective efficacy of natural products, antioxidants, and biomaterial design for other diseases.

Object-Oriented Analysis and Design for Information Systems, Second Edition clearly explains real object-oriented programming in practice. Expert author Raul Sidnei Wazlawick explains concepts such as object responsibility, visibility, and the real need for delegation in detail. The object-oriented code generated by using these concepts in a systematic way is concise, organized and reusable.The patterns and solutions presented in this book are based in research and industrial applications. You will come away with clarity regarding processes and use cases and a clear understanding of how to expand a use case. Wazlawick clearly explains how to build meaningful sequence diagrams. Object-Oriented Analysis and Design for Information Systems illustrates how and why building a class model is not just placing classes into a diagram. You will learn the necessary organizational patterns so that your software architecture will be maintainable. The Second Edition includes all new content shifting the focus of the book to agile software development, including Scrum software project management, BPMN diagrams, user stories, and Python code examples.

Sustainable Protein Sources: Advances for a Healthier Tomorrow, Second Edition explores alternative proteins, including plant, fungal, algal and insect proteins that can take the place of meat as sustainable sources to satisfy human protein needs. This revised edition presents the benefits of plant and alternative protein consumption, including those that benefit the environment, population, and consumer trends and contains new chapters on potato protein, faba bean, chickpea, and coconut. Organized by protein, chapters also cover cereals and legumes, oilseeds, pseudocereals, fungi, algae, insects and fermentation-derived dairy and meat proteins paying particular attention to the nutrition, uses, functions, benefits, and challenges of each. The book also explores ways to improve utilization and addresses everything from consumer acceptability, methods of improving the taste of products containing these proteins and ways in which policies can affect the use of alternate proteins. In addition, the book addresses sustainable protein as a pathway to securing the food supply and considers regenerative versus extractive agriculture alongside new methods in farming and water usage.

Acrylamide in Food, Second Edition, is fully updated with four new chapters that incorporate current literature on acrylamide, including analysis, formation mechanisms, levels in foods, reduction strategies, and new regulations, such as the one made by the European Union in 2017 regarding the presence of acrylamide in processed foods. The book comprises of four parts: part one introduces acrylamide and the food chain in the context of harm and health. Part two focusses on acrylamide in various types of foods, such as bakery products, fried potato products, coffee, battered products, water, table olives, etc. Part three highlights its interaction mechanisms and health effects. Part four discusses methods of analysis. Acrylamide in Food, Second Edition is edited by a team of international experts in the field and is a quality reference in the developing field of acrylamide in food. It is valuable to researchers in the food industry or working on evaluating the factors affecting the formation of acrylamide in different heat-treated foods and the possibilities of reducing acrylamide formation accordingly.

Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer. Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail.

Estimation of Time since Death in Australian Conditions collates data about decomposed bodies found in the eastern states of Australia from the years 2000 to 2010. The book takes into account that over 70% of decomposed bodies were found within 14 days. From standard autopsy reports, a quantitative method of assessing the degree of decomposition in four specific body organs and the total appearance of the body was collated into a total body score (tbs). The mathematical models on how to estimate time since death in the eastern states of Australia are covered in this valuable resource.

Fisheries and Aquaculture: The Food Security of the Future takes a multidisciplinary approach in evaluating the fisheries and aquaculture sectors from the scienti?c and practical perspectives of industry professionals. The authors recognize the importance of looking at the industry from a value chain viewpoint, not only for food security but also for a blue economy. The book takes a unique and innovative approach to show how ?sheries and aquaculture can achieve sustainability and how small ?shery communities can become highly successful ?shery and aquaculture communities and contribute to overall industry globalization. This is a practical and useful reference for a wide-ranging audience. It is for those who wish to make systematic e?orts to develop their fisheries or aquaculture sectors, scientists and researchers, anyone in ?sheries management or marine resource management, ?sh farmers, policy makers, leaders and regulators, operations researchers, as well as faculty and students.

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients. This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical field interested in understanding more about natural products with anticancer potential.

Artificial Intelligence in Precision Health: From Concept to Applications provides a readily available resource to understand artificial intelligence and its real time applications in precision medicine in practice. Written by experts from different countries and with diverse background, the content encompasses accessible knowledge easily understandable for non-specialists in computer sciences. The book discusses topics such as cognitive computing and emotional intelligence, big data analysis, clinical decision support systems, deep learning, personal omics, digital health, predictive models, prediction of epidemics, drug discovery, precision nutrition and fitness. Additionally, there is a section dedicated to discuss and analyze AI products related to precision healthcare already available. This book is a valuable source for clinicians, healthcare workers, and researchers from diverse areas of biomedical field who may or may not have computational background and want to learn more about the innovative field of artificial intelligence for precision health.

Characterization Techniques for Bionanocomposites: Advances, Challenges, and Applications provides a detailed review of current techniques used for the characterization of bionanocomposites. The chapters cover physical, chemical, thermal, and electrical characterization techniques as well as spectroscopic and microscopic methods. There is also an entire section dedicated to biodegradability and biological characterization. With its numerous case studies and practical examples, researchers will find this book a valuable information resource that enables them to identify which specialized characterization tools can be applied to different materials for a broad range of biological, environmental, and industrial applications.

Raman Spectroscopy Applied to Polymer Composites and Nanocomposites summarizes, in a comprehensive manner, recent research accomplishments in this important area. The book offers an in-depth study of the current state-of-the-art, covering the fundamentals and recent experimental developments. Almost all the characterization techniques coupled in situ with Raman spectroscopy are discussed in detail. The book also covers various aspects of polymer applications, as well as related topics in polymer composites and nanocomposites. Filled polymers, reinforced plastics, thermoplastics, thermosets, elastomers, and rubbers are also discussed.The book is designed to address all aspects of Raman spectroscopy with respect to polymers and measurements, along with experimental conditions. It contains numerous case study examples to illustrate how Raman spectroscopy coupled in situ with more classical techniques can be useful to enhance material performance.

Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others.The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies.This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system.

Phytochemicals in Cancer Therapy and Beyond examines the role of natural products in the treatment of diseases, especially cancer. With a strong focus on the treatment of diseases, it demonstrates the mechanisms that natural products follow in treatment. In 24 chapters, the book describes not only regular cancer treatments, challenges, and developments in cancer treatment, in particular, phytochemicals and cellular mechanisms in cancer therapy, phytochemicals and molecular pathways in cancer, and Nano-scale delivery systems for phytochemicals in cancer therapy. The book concludes with clinical applications of phytochemical therapies. This book is a valuable resource for researchers in the field of oncology, disease therapy, diabetes mellitus treatment, cellular signaling scientists, and nanomaterial engineers.

Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses: Fitness for Purpose, Performance-Based Criteria, and Measurement Uncertainty uses a novel Sustainable Quality Improvement (SQI) framework with the aim of helping to re-introduce much needed flexibility and restore accountability and integrity necessary for developing confidence in products obtained with these specialty assays. The book can also be used as a comprehensive reference text for data and information on matrix-specific target analytes detection/quantitation limits, and measurement of uncertainties for planning purposes, congeners profiles, multi-phasic, multi-component and multi-analyte samples processing flow charts, and useful definitions of the underlying technology-relevant terminologies. The SQI framework around which the book is constructed paves the way for the innovative technological solutions described in the book and is powered by three key elements: Fitness for Purpose (Data Quality Objectives), Performance-Based Measurement System (flexibility, latitude), and Measurement Uncertainty (accountability). Together, they facilitate the development and validation of advanced methodologies to resolve many of the contemporary issues associated with continuously evolving and demanding regulatory requirements. A stronger focus on effective performance feedback is demonstrated to help laboratories rethink their own approach to quality improvements.

Functional Connectivity of the Human Brain: From Mechanisms to Clinical Applications is a comprehensive review of mechanisms and analysis of methods of functional connectivity to map brain organization in healthy individuals and sick patients. Providing full coverage of the discipline for a wide audience of different research and clinical specialists, this volume begins with descriptions of mechanisms of functional connectivity and methodological approaches to quantify it, followed by a focus on how functional connectivity has been used to describe brain function in healthy people and to characterize network disruption in diseased conditions. This practical balance in book structure is suitable for readers with a technical or clinical orientation, providing background that is easy to approach for clinicians or scientists. Chapters examine fMRI and electrophysiological techniques, brain maturation, aging, and cognitive neurosciences, as well as functional connectivity in neuroinflammatory, neurodegenerative, and neuropsychiatric conditions. Future perspectives look forward to functional connectivity in multimodal analysis, artificial intelligence, and more. This book will be of use to a wide audience working on functional connectivity experiments, as well as any courses on the topic.

Nanostructured Lithium-ion Battery Materials: Synthesis and Applications provides a detailed overview of nanostructured materials for application in Li-ion batteries, supporting improvements in materials selection and battery performance. The book begins by presenting the fundamentals of Lithium-ion batteries, including electrochemistry and reaction mechanism, advantages and disadvantages of Li-ion batteries, and characterization methods. Subsequent sections provide in-depth coverage of a range of nanostructured materials as applied to cathodes, electrolytes, separators, and anodes. Finally, other key aspects are discussed, including industrial scale-up, safety, life cycle analysis, recycling, and future research trends. This is a valuable resource for researchers, faculty, and advanced students across nanotechnology, materials science, battery technology, energy storage, chemistry, applied physics, chemical engineering, and electrical engineering. In an industrial setting, this book will be of interest to scientists, engineers, and R&D professionals working with advanced materials for Li-ion batteries and other energy storage applications.

Primer to Neuromorphic Computing highlights critical and ongoing research into the diverse applications of neuromorphic computing. It includes an overview of primary scientific concepts for the research topic of neuromorphic computing, such as neurons as computational units, artificial intelligence, machine learning, and neuromorphic models. It also discusses the fundamental design method and organization of neuromorphic architecture. Hardware for neuromorphic systems can be developed by exploiting the magnetic properties of different materials. These systems are more energy efficient and enable faster computation . Magnetic tunnel junctions and magnetic textures can be employed to act as neurons and synapses. Neuromorphic systems have general intelligence like humans as they can apply knowledge gained in one domain to other domains.

Multiscale Modelling of Concrete covers all things concrete, including comprehensive discussions on this multi-phase and multi-scale material that is difficult to model and understand due to its heterogeneity. Thus, knowing the properties and modeling concrete in different scales is essential to predict properties and fracture. Most of the research has been focused on meso scale, or the methods available to model and predict micro-scale properties are not linked to experimental methods, so properties for microscale cannot be derived and it is onerous to validate such methods.Considering the above constraints, the book covers different modelling techniques of scales of concrete - macro, meso, micro/nano and molecular level, characterizing mechanical properties and parameters required for modelling using macro and micro level experiments and linking these levels using analytical and numerical methods to upscale results from micro to the macro level.

Wave Optics in Infrared Spectroscopy starts where conventional books about infrared spectroscopy end. Whereas the latter are based on the Bouguer-Beer-Lambert law, the cornerstones of this book are wave optics and dispersion theory.This gap between both levels of theory is bridged to allow a seamless transition from one to the other. Based on these foundations, the reader is able to choose which level of theory is adequate for the particular problem at hand. Advanced topics like 2D correlation analysis, chemometrics and strong coupling are introduced and viewed from a wave optics perspective. Spectral mixing rules are also considered to better understand spectra of heterogeneous samples. Finally, optical anisotropy is examined to allow a better understanding of spectral features due to orientation and orientational averaging. This discussion is based on a 4 x 4 matrix formalism, which is used not only to simulate and analyze complex materials, but also to understand vibrational circular dichroism from a (semi-) classical point of view.Wave Optics in Infrared Spectroscopy is written as a tool to reunite the fragmented field of infrared spectroscopy. It will appeal to chemists, physicists, and chemical/optical engineers.

Statistical Analysis for Civil Engineers: Mathematical Theory and Applied Experiment Design is a well-researched and topically organized reference book that guides its readers, both in academia and industry, to recognize how to describe unpredictable events in a quantitative way and to learn how these events can be incorporated into practical engineering analysis that facilitates data-driven problem solving and optimization-based decision-making.Written by experts in the field with a proven track record as educators and practicing consultancy specialists, this book has been developed in such a manner that it advances understanding of the mathematical theory underlying analytical methodology gradually. It also supports practical application through relevant worked examples in a variety of civil engineering branches, notably structural, materials, transportation, and geotechnical engineering. Through all stages of data analysis, numerical modeling and simulation, and implementation, the volume emphasizes the need to change the current perception with respect to the use of modern statistical techniques in the scientific as well as practical spheres of civil engineering.

Functional Foods: Principles and Technology, Second Edition covers the definition, history, and development trends of functional foods. Specifically, this updated edition discusses the chemistry of functional components and their physiological properties of functional foods, including antioxidants, dietary fiber, pre-, pro-, and paraprobiotics, symbiotics, and postbiotics, selected nutritional supplements, soy and soy foods, human milk biochemistry and infant formula, sports drinks chemistry, and formulation aspects. This book is sure to be of interest to food and nutrition researchers, pharmacologists, and those teaching and studying related fields.

Smart Biomimetic Coatings: Design, Properties and Biomedical Applications summarizes vital research in multifunctional (i.e., anti-corrosion, anti-fouling, and self-cleaning properties) surface coatings in various applications such as orthopedic and dental implants, tissue engineering, sensors and more. The book introduces biomimetic coatings, aiding understanding of highly complicated architectures in natural composites, along with discussions on the importance of proper mimicking to achieve composite materials with exceptional performance. The synthesis and unique properties of smart biomimetic coatings are detailed before a wide selection of biomedical applications is explored.This is an important reference of interest to researchers and R&D groups working in materials science, biomedical engineering, tissue engineering, and implant design.

Spinel Ferrite Materials: Fundamentals, Progress, and Applications provides a systematic and comprehensive review of the latest research in ferrite materials to assist students and researchers from the academy and industry. The book focuses on the synthesis methodology, the structural, electrical, and magnetic properties, and various applications of spinel ferrites. In addition, it investigates the structural, electrical, and magnetic characteristics of spinel ferrite nanoparticles, with a particular focus on synthesis techniques and subsequent applications in biomedicine, microwave absorption, nanoelectronics, wastewater treatment, sensing, and photocatalysis.

Emerging Paradigms in Delivery of Therapeutic Agents for the Treatment of Glioblastoma describes the intense research and clinical developments that are required to optimize the available treatment options and the potential side effects to heal brain cancer. The success of this strategy includes the use of validated biomarkers, appropriate patient selection criteria, strategies to prevent adverse events, and the implementation of immunotherapy in multimodal treatment approach. In 18 chapters, this title sets forth the rationales for promising therapies like immunotherapy, including immune checkpoint blockade, chimeric antigen receptor T (CAR T) cell therapy, oncolytic virotherapy, and vaccine therapy.In addition, the book reviews potential novel agents, the current status of preclinical and clinical trials, and the challenges and future perspectives in glioblastoma immuno-oncology. This book is a valuable resource for health professionals, scientists and researchers, health practitioners, students, and all those who wish to broaden their knowledge in the allied field.

Polymer Gears discusses polymer gear design and their efficient mechanical properties, light weight, and low noise during operation. As plastic gears are replacing metallic gears in traditional and new applications, there is still lack of material characterization and complex relations between different geometric and operating parameters. Thus, polymer gear design remains an open challenge. This book serves as a comprehensive and professional guide on the topic, providing readers with current developments carried out in the field of plastic gears production, characterization, and applications. This will include material development, tribological properties, simulations, and processing methods.

Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology.The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry.

Innovating Health Against Future Pandemics covers the key aspects which drive heterogeneity in an individual's response to COVID-19, including age, sex, genetic makeup, immune responses, comorbidities, and viral strains/loads. This book also reviews the case examples from other disciplines to highlight areas where precision medicine and AI could be applied for the improvement of pandemic management. This includes research, primary and secondary prevention, isolation/tracking, hospitalization and patient management, diagnosis, and treatments. Lastly, drawing on past experiences for each of the areas this book provides practical recommendations to manage future pandemics.COVID-19 offered an unprecedented occasion to test the impact of digitally enabled solutions within precision medicine for public health and for accelerating their deployment and adoption.