Böcker utgivna av Elsevier Science

Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1.The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets.

Practical Aspects of Electroorganic Synthesis presents an educational insight into the practical aspects of electrosynthesis methods by providing a variety of examples and techniques. With the advancement of chemical science and its undeniable role in life, there is a growing need for the employment of green and eco-friendly methods and environmentally acceptable processes to minimize the negative consequences of chemical technologies. These needs and concepts are referred to as "green chemistry? and "sustainable technology?. Electrosynthesis techniques are an example of one of the notable achievements of the interdisciplinary co-operation that assists in minimizing these consequences. This book comprises three fundamental sections: direct, indirect, and paired electrolysis. As a result, this logically separates the key information needed to conduct electrochemistry into digestible and rational parts. Direct electrolysis discusses anodic oxidation, cathodic reduction, mechanistic studies (cyclic voltammetry), and how to set up electrochemical experiments. Indirect electrolysis proceeds to explore catalysts and additives in more depth to take on modern electrochemical methods. Finally, this book explores the burgeoning new field of paired electrolysis, in which the ultimate green-synthesis applications are possible, with no wasted electrons and very few by-products. Practical Aspects of Electroorganic Synthesis offers researchers a modern and authoritative resource that brings complete and up-to-date practical concepts of electrosynthesis methods and guides the audience on how to carry out a large number of experimental techniques.

Modern Manufacturing Processes for Aircraft Materials presents a detailed review of advanced manufacturing processes exclusively used for aircraft materials, including metals, polymers and composites. Advanced manufacturing methods are discussed as well as recent non-conventional manufacturing methods for aircraft-specific materials. Key important processes discussed include additive manufacturing for both polymeric and metallic materials, electrical discharge machining, laser welding, electron beam welding, and micro-machining. In addition to the theoretical discussion, various examples of case studies are presented from reputable research centers, and institutes.This will be a valuable reference resource for academic researchers, materials scientists, and industrial engineers working in manufacturing of advanced materials for the aircraft industry.

Mechanoluminescence in Organic and Inorganic Compounds: Basic Concepts, Instrumentation, and Applications provides a comprehensive overview of mechanoluminescence for newly qualified researchers and scientists across multiple related fields. It serves as a guide for budding scientists to advance in the field through various applications covered in this book, such as energy, mechanics, medicine, and optics. This reference shines light on the pros and cons of utilizing organic or inorganic mechanoluminescent materials, making it a handy tool for researchers worldwide involved in luminescence and applications such as optoelectronics, sensors, forensics, displays, energy harvesting, and smart robotics. The editors and their expert contributors summarize these applications, making it a valuable resource for academics, researchers, and those working in industry.Mechanoluminescence in Organic and Inorganic Compounds contains broad coverage, which progresses from theory to applications, serves as a complete reference of global research and experience, which will work to inform and guide the development of more efficient devices for the future.

Oxygen, Nitrogen and Sulfur Species in Post-harvest Physiology of Horticultural Crops, a volume in the Plant Gasotransmitter series, analyzes the latest advances in post-harvest physiology. The book presents metabolic cascades and highlights the role of gasotransmitters as intercellular regulators of metabolic processes. Post-harvest physiology differs between climacteric and non-climacteric fruits and vegetables, as well as for fresh-cut flowers and non-food plants. Initial chapters review the cascades, intercellular pathways and messenger molecules that drive ripeness and longevity, presenting the chemistry behind key pathways. The books also takes a deep dive into core gasotransmitters, describing the data behind known properties, chemistry and physiological roles. Applications for prolonging shelf-life via the control of post-harvest fungi, bacteria and omics approaches are reviewed in detail, offering readers guidance on how to put gasotransmitters research into practice. This is an essential resource for students, researchers and agronomists interested in plant physiology, biochemistry and plant hormones.

Handbook on Thermal Hydraulics of Water-Cooled Nuclear Reactors, Volume Three, Procedures and Applications includes all new chapters which delve deeper into the topic, adding context and practical examples to help readers apply learnings to their own setting. Topics covered include experimental thermal-hydraulics and instrumentation, numerics, scaling and containment in thermal-hydraulics, as well as a title dedicated to good practices in verification and validation. This book will be a valuable reference for graduate and undergraduate students of nuclear or thermal engineering, as well as researchers in nuclear thermal-hydraulics and reactor technology, engineers working in simulation and modeling of nuclear reactors, and more. In addition, nuclear operators, code developers and safety engineers will also benefit from the practical guidance provided.

Plasticizers are vital to the plastics industry, particularly in improving the properties of materials such as PVC. The Handbook of Plasticizers, now in its third edition, is an essential professional reference, providing information that enables R&D scientists, production chemists and engineers the information they need to use plasticizers more effectively, and to avoid certain plasticizers in applications where they may cause health or material durability problems. Plasticizers are commonly added to complex mixtures containing a variety of materials, so successful incorporation requires a broad understanding of the mechanisms of plasticizer action, and compatibility with different materials and blends. There is a large selection of commercial plasticizers, and various environmental issues which impact on selection decisions. The book discusses new and historical approaches to the use of plasticizers, which explain mechanisms of plasticizers'' action and their behavior in plasticized systems. It goes into detail on the use of plasticizers in a range of specific polymers, polymer blends, and other industrial products. This includes coverage of the impact of plasticizers on processing. George Wypych provides the data and knowhow from the most recent sources and updated information required by engineers and scientists working in the plastics industry and the many industry sectors that use plastics in their products. The book covers the uses, advantages, and disadvantages of plasticizers, historical and theoretical background, their effects on process conditions, and health, safety, and environmental issues. Enables materials scientists, chemists and engineers to use plasticizers more effectively, and avoid health and safety or performance risksIncludes detailed coverage of the impact of plasticizers on polymers, and processing methodsProvides the broad background of information required to select the correct plasticizer for any application

Handbook of Surface Improvement and Modification contains information on several groups of additives and the modification processes which determine the surface properties of many materials. These additives can modify or improve scratch and mar resistance, improve gloss or flatten the surface, increase or decrease tack and inhibit staining. The mechanisms of damage, protection and property improvements are also discussed, making this an essential handbook for engineers, researchers and technicians interested in using additives to modify and improve the surface properties of materials. A companion book entitled Databook of Surface Modification Additives has also been published. It contains information and data on the additives commercially available to improve materials by the above-listed modifications. Both books do not repeat information. In this book, the focus is on the methods and mechanisms which are known to be responsible for the enhancement of material properties with the use of additives. Focuses on the improvement of surface properties, with detailed coverage of the additives used, including the process of selection and examples of applicationPresents the mechanisms of damage, protection and property improvements based on research dataAids the user in formulating products that fit specific requirements and applications

Databook of Surface Modification Additives contains data on 7 groups of additives, including anti-scratch and mar-preventing additives, gloss enhancement and surface matting additives, additives for formation of tack-free surface and tackifiers, and stain inhibiting additives. The information on each adhesion promoter is divided into five sections, including General Information, Physical Properties, Health and Safety, Ecological Properties and Use and Performance. This databook will be an extremely useful source of data for engineers, researchers and technicians interested in using additives to modify and improve the surface properties of materials. Provides detailed, up-to-date, essential data on 7 groups of additivesCovers general information, physical-chemical properties, health and safety, ecological properties and use and performanceIncludes recommendations for specific products, applications, processing methods and the concentration used

Handbook of Polymer Processing Additives provides insights on the selection of additives, their performance mechanisms, essential application properties, and a complete analysis of related literature and patents. Acid scavengers, air release, anticaking, antigassing, anti-gelling, anti-settling, hydrolysis stabilizers, and moisture scavengers are each covered. Information on the use of additives in various products is divided into sections on types, concentrations, usage, advantages and disadvantages, effects on product properties, and examples of formulation. Processing methods are similarly divided into sections on types and concentrations, effects on the process, effect on product properties, advantages and disadvantages, and examples of formulation. All essential aspects of chemistry, physical properties, influence on properties of final products, formulations, methods of incorporation, analysis and effects on health and environment are considered. The book is an excellent companion to the Databook of Polymer Processing Additives.

Databook of Polymer Processing Additives provides key information on the properties of polymer processing additives, covering their general information, physical properties, health and safety considerations, ecological properties, and use and performance details. Acid scavengers, air release, anticaking, antigassing, anti-gelling, anti-settling, hydrolysis stabilizers, moisture scavengers, and more are all covered, providing readers with key data aiding in the proper selection of these additives. The book is an excellent companion to the Handbook of Polymer Processing Additives.

Power Electronics Converters and their Control for Renewable Energy Applications provides information that helps to solve common challenges with power electronics converters, including loss by switching, heating of power switches, management of switching time, improvement of the quality of the signals delivered by power converters, and improvement of the quality of energy produced by renewable energy sources. This book is of interest to academics, researchers, and engineers in renewable energy, power systems, electrical engineering, electronics, and mechanical engineering.

Future Proteins: Sources, Processing, Applications and the Bioeconomy presents sources of alternative proteins and the novel processing technologies associated with these new proteins, including their vast food and non-food applications and their contributions to the circular economy that ties them together. Broken into three sections, chapters focus on alternative proteins including cereals, legumes and pulses, fungi, seafoods, insects, and others before assessing novel production technologies and alternative protein applications. Through the use of content features, specifically definitions, case studies, recent developments, data, and methods, this reference assists readers in understanding how to apply current knowledge and techniques to their research. This book is intended for any stakeholders involved in the alternative protein industry as it provides a clear and comprehensive review of the industry. It will be of interest to food scientists, technologists, food industry personnel, academics and graduate students researching this and related topics.

Nanostructured Materials Engineering and Characterization for Battery Applications is designed to help solve fundamental and applied problems in the field of energy storage. Broken up into four separate sections, the book begins with a discussion of the fundamental electrochemical concepts in the field of energy storage. Other sections look at battery materials engineering such as cathodes, electrolytes, separators and anodes and review various battery characterization methods and their applications. The book concludes with a review of the practical considerations and applications of batteries.This will be a valuable reference source for university professors, researchers, undergraduate and postgraduate students, as well as scientists working primarily in the field of materials science, applied chemistry, applied physics and nanotechnology.

Flexible Distribution Networksfacilitates the enhanced flexibility, efficiency and reliability of distribution networks under complex operating environments delivered by high DG penetration. Considering the high share of DG and flexibility improvement brought by SOP-type power electronic devices, the work aims to solve the issues of optimal operation of flexible distribution networks. Technical solutions for flexible operation problems of FDN are discussed in depth, including efficient analytical methods with high penetration of DG, SOP-based optimal operation methods with uncertainty, and high-performance convex optimization algorithms.Readers will develop sound knowledge and gain insights into the optimal operation of FDN with high penetration of DG.

Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented. Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.

The Science of Human Milk offers readily understandable, scientifically sound information related to the compositional features of human milk at different stages of lactation. The book also debunks many myths about human milk and provides an analysis of the differences in human milk and baby formulas, offering suggestions for how the latter can be improved. The correlation between human milk composition and infant physiology and metabolism, growth, development, health and disease is explored in detail, placing emphasis on preterm infants. In addition, the dynamic nature of human milk, including its microbes, immunology, metabolites, cell components and epigenetically active molecules are covered. Written for researchers working in nutrition and neonatology, as well as health care professionals working in related fields, this book is sure to be a welcomed reference.

Ices in the Solar System: A Volatile-Driven Journey from the Inner Solar System to Its FarReaches explores the origins, evolution and distribution of various ice species throughout thesolar system.Geographically, the book's focus on ice(s) migrates outwardly from Mercury, the Earth and theMoon, Mars, then Ceres and other volatile-rich small bodies; it carries on with the moons ofJupiter, Saturn, and Uranus, followed by Pluto and other Kuiper Belt/Trans-Neptunian objects.Conceptually and empirically, the book depicts the often-enigmatic narratives of the differentice species (H2O, CO2, CH4, etc.) in the solar system and examines their interaction with a widerange of surface, near-subsurface, interior and atmospheric processes.

Deployment of Carbon Capture and Storage: Insights, Case Studies, and Key Learnings presents the latest research and technologies on Carbon Capture and Storage (CCS), building on the topics to provide case studies and lesson learned from early stage projects. The book highlights CCS storage technologies deployed at scale to offer readers insights and guidance that will ensure they make sound decisions when developing CCS programs. Cost and risk minimization techniques are included to minimize cost and risk for wide-scale commercial deployment required by 2050. Global case studies on CCS technology and high TLR provide readers with unique insight into worldwide activity. Readers will gain a thorough understanding of the full CCS chain as applied across multiple settings including energy, chemical, geological and environmental industries, as well as an authoritative understanding of international policy and regulation factors.

Biomechanics of the Female Reproductive System: Breast and Pelvic Organs: From Models to Patients synthesizes complementary advances in women's reproductive biomechanics, medical imaging analysis, patient-specific characterization, and computational finite element models. The book discusses the biomechanical aspects related to the breast and female pelvic floor system at each step of development. The table of contents also covers certain events and diseases, including cancers, delivery, aging, breast, hysterectomy or prolapse surgery. It presents the main biomechanical experimental results obtained and models developed this last decade to highlight the importance of accounting for patient-specific history and aging characteristics to consider damage growth effect and impact. As part of Elsevier's Biomechanics of Living Organs series, this book provides an opportunity for students, researchers, clinicians and engineers to study the main topics related to the biomechanics of the women's reproductive system in a single book written by a global base of experts.

With emerging biological threats from pathogenic microorganisms and increasing environmental pollutants, it is essential to ensure the safety needs of individuals and the ecosystem are met. Modern materials science and engineering has evolved over the years to better develop devices to test abnormalities. Affordability, accessibility, and reliability of any analytical system is the prime necessity for a modern diagnostic application. Health and Environmental Applications of Biosensing Technologies: Clinical and Allied Health Science Perspective presents a detailed overview on biosensor design systems and optimal fabrication technologies to create a greater impact on various industries and help organizations break existing performance tradeoffs to deploy biosensor technologies across inter/transdisciplinary businesses. The book presents novel and emerging trends in biosensor design and healthcare applications focused on API detection, communicable/non-communicable disease diagnosis, food quality monitoring, agro-environmental analysis, bio-defense, and industrial pollutant sensing. In addition, wearable biosensors, commercial products, and safety regulations for biosensing technologies are summarized.

Microirrigation for Crop Production: Design, Operation, and Management, Second Edition is the latest release in this go-to foundational resource for the basics of engineering and the science of the design and operation of micoirrigation systems. This new edition includes novel methods for measurement and estimation of evapotranspiration, resource-efficient microirrigation design and operation, advanced irrigation scheduling methods and tools, novel methods and technology of microirrigation automation, monitoring and control, updates in crop salinity tolerance and leaching practices, variable rate irrigation, updates on the use of biological effluents and chemicals and pesticides to include safety and regulatory concerns.The revised book will provide an understanding on the basic science needed to comprehend systems design, operation, management, maintenance, monitoring and performance evaluation.

Advanced Ceramic Coatings for Biomedical Applications covers tissue engineering, scaffolds, implant and dental application, wound healing and adhesives. The book is one of four volumes that together provide a comprehensive resource in the field of Advanced Ceramic Coatings, also including titles covering: fundamentals, manufacturing, and classification; energy applications; and emerging applications. This books will be extremely useful for academic and industrial researchers and practicing engineers who need to find reliable and up-to-date information about recent progresses and new developments in the field of advanced ceramic coatings. It will also be of value to early career scientists providing background knowledge to the field. Smart ceramic coatings containing multifunctional components are now finding application in transportation and automotive industries, in electronics, and energy sectors, in aerospace and defense, and in industrial goods and healthcare. Their wide application and stability in harsh environments are only possible due to the stability of the inorganic components used. Ceramic coatings are typically silicon nitride, chromia, hafnia, alumina, alumina-magnesia, silica, silicon carbide, titania, and zirconia-based compositions. The increased demand for these materials and their application in energy, transportation, and the automotive industry, are considered, to be the main drivers.

Handbook of Thermosetting Foams, Aerogels, and Hydrogels: From Fundamentals to Advanced Applications presents the latest knowledge on the preparation, characterization, properties, and applications of thermoset foams, aerogels, and hydrogels. This book begins by introducing thermoset foams, aerogels, and hydrogels, their characteristics, current applications, potential for further development, and environmental impact. This is followed by three sections, each focusing on foams, aerogels, and hydrogels developed from a specifi c thermosetting polymer category, covering polyurethane, epoxy resins, and formaldehyde. In each section, detailed coverage guides the reader through the preparation, structure, characterization, properties, processing, and applications of foams, aerogels, and hydrogels based on that material, as well as addressing key challenges in terms of design, processing, and implementation, and possible solutions. This is a valuable resource for researchers and advanced students with an interest in thermoset lightweight materials, across the disciplines of polymer science, chemistry, nanotechnology, materials science, and engineering. This is also of interest to R&D professionals, engineers, and scientists working with foams, hydrogels, and aerogels for a range of applications and industries.

Plant-Based Food Consumption: Product, Consumers and Strategies explores the phenomenon of plant-based food consumption, specifically that which follows flexitarian, reducetarian, vegetarian and vegan diets. The book provides an overview of plant-based food products and their associated health and nutrition benefits, drawbacks, potential consumers, and strategies for approaching this emerging market. Moving from the analysis of consumers' motivations and needs, the book describes how companies manage new product development or product rejuvenation. In addition, the book provides consumer science and marketing strategies through short case studies designed to help the reader understand how to put theory to practice. Food scientists, food developers, food marketers, academics and students studying related areas will benefit from this important reference.

Sustainability and Toxicity of Building Materials: Manufacture, Use and Disposal Stages provides a review of toxicity impacts from building materials, including the consideration of the toxicity in the extraction and manufacture of the materials and eventual dismantling and disposal. This book also offers the potential to stimulate future developments in this area, both in terms of knowledge-building and methods for future research. With the increasing emphasis on sustainable construction, it has become important to better understand the impacts of common materials. Civil and structural engineers, postgraduates, researchers as well as architects will find this book to be useful in selecting sustainable building materials.While many building and furnishing materials are safe to use, in recent decades, some have had to be redesigned due to recognition that they contained problem chemicals like formaldehyde. Unfortunately, there is still limited understanding of the toxic impacts of many synthetic chemicals which means that the risks in this area are not well recognized. With increasing interest in using limited resources more sustainably, definitions of what is sustainable should be expanded to move from the focus on energy and carbon impacts to also include more explicit consideration of toxicity impacts.

Clinical Neuroepidemiology of Acute and Chronic Disorders explores the epidemiology of disorders that affect the nervous system, providing comprehensive discussions on incidence, prevalence, and more. With thorough coverage of a variety of disorders, chapters detail etiology, risk factors, pathophysiology, clinical manifestations, diagnosis, global incidence and prevalence, age-specific incidence, global mortality, prevention, treatment and prognosis for each disorder. Chapters uniquely discuss the effects of the COVID-19 coronavirus upon the nervous system and in relation to several diseases, including new discoveries and treatments for Alzheimer's disease and migraine headaches. Real-world case studies with critical thinking questions and "Focus On" boxes highlight important information.