Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.
Human-Machine Interaction for Automated Vehicles: Driver Status Monitoring and the Takeover Process explains how to design an intelligent human-machine interface by characterizing driver behavior before and during the takeover process. Multiple solutions are presented to accommodate different sensing technologies, driving environments and driving styles. Depending on the availability and location of the camera, the recognition of driving and non-driving tasks can be based on eye gaze, head movement, hand gesture or a combination. Technical solutions to recognize drivers various behaviors in adaptive automated driving are described with associated implications to the driving quality. Finally, cutting-edge insights to improve the human-machine-interface design for safety and driving efficiency are also provided, based on the use of this sensing capability to measure drivers' cognition capability.
Advanced Fiber-Reinforced Alkali-Activated Composites: Design, Mechanical Properties, and Durability covers various fiber types and their usage as a sustainable material as well as their influence on mechanical properties and behavior, including compressive strength, tensile strength, flexural strength, and impact and bond resistance. Their durability in different environments (seawater, magnesium sulphate, sulphuric acid, elevated temperature, corrosive) is also discussed. The book also outlines a variety of mix design and curing regimes for alkali-activated composites. The additive manufacturing of these composites is also covered. Different types of fiber-reinforced alkali-activated composites discussed include steel fiber-reinforced, carbon fiber-reinforced, natural fiber-reinforced, synthetic fiber-reinforced, and others.
Renewable Dyes and Pigments takes an interdisciplinary approach to bridging the gap between established knowledge of traditional natural dyes and pigments and their emerging aspects in various rapidly growing industrial sectors. Research into new natural dye and pigment sources along with the discovery of sophisticated instrumentation and technology for their processing, characterization, and applications has greatly assisted in widening their scope in various advanced application disciplines is covered, along with information on a number of synthetic dyes and their detrimental effects on the environment and associated allergic, toxic, carcinogenic, and harmful responses. Amidst growing environmental and health concerns, eco-friendly, non-toxic dyes and pigments from renewable materials have re-emerged as a potential viable, sustainable option as an alternative or co-partner to synthetic compounds. This book covers a wide range of topics related to the chemistry and applications of natural dyes and pigments, with an emphasis on recent technological developments in textile dyeing, the food sector and the use of natural pigments in dye-sensitized solar cells, and more.
Integrative Strategies for Bioremediation of Environmental Contaminants, Volume Two: Avenues to a Cleaner Society focuses on the exploitation of various biological treatment technologies and their use to treat toxic contaminants present in industrial effluent to restore contaminated sites. The book includes coverage of combined treatments of microbes for reuse of wastewater and contaminated soil to successfully achieve eco-restoration, environment protection and sustainable development. In 14 chapters, this reference compiles current and advanced biotechnologies as well as future directions for research. This is a valuable resource for researchers in microbiology, biotechnology, environmental engineering and environmental science, and all those who wish to broaden their knowledge in the field of applied microbiology to develop sustainable waste management.
The Brain of the Critically Ill Pregnant Woman is a volume in the Critical Care in Obstetrics series. This novel reference educates physicians, nurses, and all allied healthcare personnel on updates for caring for pregnant women with neurological compromise. The book's authors have gathered the best evidence-based material that is explicitly focused on severe neurological complications in pregnant patients and postpartum. Among the chapters, the book covers medical-surgical complications that any patient can present, such as head trauma and complications specific to pregnancy.
Four-Membered Heterocycle Synthesis offers a comprehensive approach to these unstable organic compounds, providing a systematic introduction to the synthesis and reactions of all common four-membered heterocycles and illustrating different methods to prepare specific four-membered heterocycles. Four-membered heterocyclic compounds are known as a class of unstable organic compounds because of their strain characteristics, which make them very beneficial as precursors for the formation of a broad range of complex heterocyclic molecules and for synthetic elaboration.
Corrosion engineers today spend enormous amounts of time and money searching multiple detailed sources and variable industry-specific standards to locate known remedies to corrosion equipment problems. Corrosion Atlas Series is the first centralized collection of case studies containing challenges paired directly with solutions together in one location. The second release of content in the series, Corrosion Atlas Case Studies: 2021 Edition, gives engineers expedient daily corrosion solutions for common industrial equipment, no matter the industry. Providing a purely operational level view, this reference is designed as concise case studies categorized by material and includes content surrounding the phenomenon, equipment appearance supported by a color image, time of service, conditions where the corrosion occurred, cause, and suggested remedies within each case study. Additional reference listings for deeper understanding beyond the practical elements are also included. Rounding out with an introductory foundational layer of corrosion principles critical to all engineers, Corrosion Atlas Case Studies: 2021 Edition delivers the daily tool required for engineers today to solve their equipment's corrosion problems. Solves equipment failure with easy-to-find remedies organized by essential elements such as materials, system, part, cause, environmental, and phenomenon Grasps fundamental corrosion elements on all major industrial pieces of equipment, no matter the industry Identify failures by appearance with color figures within each case study
Autoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms by which infectious agents can trigger autoimmunity such as molecular mimicry and polyclonal activation. An overview is given with regard to bacteria, viruses, and parasites associated with autoimmunity, and a summary is given on classical autoimmune diseases and the infecting agents that can induce them. Includes completely updated and new chapters Brings the reader up to date and allows easy access to individual topics in one place Identifies infectious agents as pathogenic or protective in many autoimmune diseases
Pediatric Epilepsy Surgery Techniques: Controversies and Evidence offers clinicians a roadmap for navigating the complex decision-making process involved in selecting surgical interventions for children with drug-resistant epilepsy. Over the last decade, the landscape of pediatric epilepsy surgery has undergone substantial transformation, marked by the introduction of several emerging technologies that are now supported by an expanding body of evidence, yet leading to a wide range of treatment practices. This book addresses several decision-making dichotomies in pediatric epilepsy surgery, both in terms of established and novel surgical modalities and techniques. The book explores long-standing debated topics, such as the relative benefits of disconnective compared to resective strategies, the utility of surgical adjuncts like intra-operative electrocorticography, as well as rationales for different surgical approaches, namely selective amygdalo-hippocampectomy versus anteromesial temporal lobectomy. Further, it addresses dichotomies between traditional approaches and contemporary modalities, such as microsurgical resection versus laser interstitial thermal therapy. Chapters also offer comparisons of modern technologies, such as different neuromodulation strategies, including vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation.This book provides readers with the relevant scientific literature and expert commentary to inform evidence-based approaches to surgical care in pediatric drug-resistant epilepsy.
Cannabis and Khat in Drug Discovery: The Discovery Pipeline and the Endocannabinoid System provides comprehensive coverage of two important psychoactive plants: Khat and Cannabis. Initial research has found that compounds and derivatives from Cannabis and Khat are found to have promising properties that can be used for the discovery, design and development of potential drug leads against various diseases. This book extensively discusses the drug discovery and allied sciences of these compounds in the drug discovery pipeline, including basic research and computer aided modeling in ligand-drug interactions and their interactions with the endocannabinoid system. Categorized into sections including, chemical analyses and bioassays, medicinal chemistry, chemical biology and pharmacology, clinical applications, and policy and regulations, this book covers the methods and protocols involved and will be of interest to students, researchers, policymakers and all those involved in drug discovery research.
Smart Diagnostics for Neurodegenerative Disorders: Neuro-sensors explores all available biosensor-based approaches and technologies as well as their use in the diagnosis, prognosis and therapeutic management of a variety of neurological disorders such as Alzheimer's, Parkinson's and epileptic disorders. The book also discusses contemporary and revolutionary biosensor platforms that are being used to produce a quantitative quick lab-on-a-chip point-of-care (POC) assay for several types of predictive and diagnostic biomarkers linked with neurodegenerative disorders. It offers a combinatorial strategy for learning recent advances and designing new biosensor-based technologies in the fields of medical science, engineering and biomedical technology. Early detection of neurological conditions has the potential to treat the disease and extend the life expectancy of patients. Recent improvements in biosensor-based approaches that target specific cell surface biomarkers can be used for early detection of neurodegenerative disease.
Biomechanics of the Aorta: Modeling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.
The Handbook of Natural Polymers, Volume Two: Functionalization, Surface Modification, and Properties covers modifications, functionalization, analysis and properties of polymers from natural sources. The book begins by introducing the current state-of-the-art, challenges and opportunities in natural polymers. This is followed by detailed coverage of methods for chemical, physical and surface modifications, and functionalization of natural polymers, including nanocellulose composites, gluten, chitin, alginate, pectin, keratin, shellac, wool, hemicellulose, lignin, natural rubber, albumin, collagen, gelatin, zein, soya protein, silk fibroin, gutta percha and gum. The final chapters explain several other key aspects, such as microscopical and spectroscopical analysis, mechanical, thermal, and more. The book aims to offer potential avenues for the preparation, modification, and implementation of advanced natural polymer-based materials with the desired properties for specific applications.
From Brain Dynamics to the Mind: Spatiotemporal Neuroscience explores how the self and consciousness is related to neural events. Sections in the book cover existing models used to describe the mind/brain problem, recent research on brain mechanisms and processes and what they tell us about the self, consciousness and psychiatric disorders. The book presents a spatiotemporal approach to understanding the brain and the implications for artificial intelligence, novel therapies for psychiatric disorders, and for ethical, societal and philosophical issues. Pulling concepts from neuroscience, psychology and philosophy, the book presents a modern and complete look at what we know, what we can surmise, and what we may never know about the distinction between brain and mind.
Core Topics in General & Emergency Surgery provides a short, up-to-date and practical reference guide for surgical trainees and established consultants needing a refresher. The seventh edition has been edited and fully revised by respected experts in their fields, and provides a full list of current references and relevant resources. It covers a range of topics relevant to all areas of surgical practice - beyond surgical knowledge - that are essential for enhanced patient outcomes. These include quality improvement in emergency surgery, evaluation of new technology, evaluation of surgical literature, and human factors. This volume is part of the Companion to Specialist Surgical Practice series, the pre-eminent reference for trainees in general surgery and those preparing for the FRCS examinations. Each volume summarises key issues within each surgical sub-specialty and provides evidence-based recommendations to support practice. Covers relevant topics not found in other surgical textbooks - essential to improve surgical outcomes Concise and easy to follow - ideal for exam revision or as a refresher aid Fully updated with latest evidence on recent developments, management issues and operative procedures International authorship offers a world view Evidence-based recommendations to support practice Key references to support content, plus a comprehensive list of references in the accompanying eBook Links to recommended online videos for further learning New chapters on surgical technology, quality improvement in emergency surgery All chapters revised and updated
ICC Handbook of 21st Century Cereal Science and Technology highlights the importance of cereals, presenting insights into the foundational structure of cereal grains, including potential contamination factors that can negatively impact cereal and grain yield. Focusing on the eight major cereal crops - wheat, maize, rice, barley, sorghum and millets, oats, rye and pseudocereals, this is the only available reference to provide standardized coverage for detailed comparison. Written by a global team of expert editors and contributors, the book provides practical insights into the utilization of cereals, grains and safety assessments. This International Association for Cereal Science and Technology endorsed volume continues their commitment to international cooperation through the dissemination of knowledge, conducting research and developing standard methods.
Abalone: Biology, Ecology, Aquaculture and Fisheries, Volume 42 in the Developments in Aquaculture and Fisheries Science series, describes the taxonomy of more than 50 abalone species worldwide. The content contains information on the biology, physiology and ecology of each species as well as reproduction, genetics, diseases and parasites. It includes abalone fisheries in different parts of the world, detailing abalone aquaculture in China, Japan, Korea, Australia, Europe and Western North America. This reference takes a comprehensive approach to understanding overall shellfish management, making it valuable to fisheries, marine biologists and researchers studying shellfish, aquaculture and the ocean environment. This will also be a great resource for government and academia professionals interested in aquaculture and fisheries and their sustainable futures.
Cytokine Response Against Major Human Viral Infections provides in-depth coverage of the immunological response against human viral infections and the role and impact of cytokines on disease pathogenesis and host immune response.Cytokines, as a part of innate immunity, initiate the development of antiviral and TH 1-type immune responses. Cytokines also affect the adaptive immune response and disease manifestation. In five sections, this book gives a comprehensive introduction to the clinical manifestations of viral and infectious diseases; details the role of cytokines in DNA virus infections, RNA virus infections, and reverse transcribing virus infections; and gives insights into the recent advances and strategies in diagnostic tools and therapeutic and prophylactic measures.Cytokine Response Against Major Human Viral Infections is valuable resource for both researchers in immunology and virology, as well as for those in the biotech and pharmaceutical industries, engaged in the study of cytokines and their immunological response against human viral infections.
Ceramic Matrix Composites: Lifetime and Strength Prediction Under Static and Stochastic Loading focuses on the strain response and lifetime prediction of fiber-reinforced ceramic-matrix composites under stress-rupture loading at intermediate temperatures. Typical damage mechanisms of matrix cracking, interface debonding and oxidation, and fiber's oxidation and fracture are considered in the micromechanical analysis. Effects of composite's constituent properties, peak stress, and testing temperature on the composite's strain response and lifetime are also analyzed in detail. Finally, a comparison of constant and different stochastic stress spectrum on composite's damage evolution and fracture is discussed. This book will be a practical guide for the material researcher and component designer needing to better understand the composite's damage and fracture behavior under stress-rupture loading at intermediate temperatures.
Polymeric Adsorbents: Characterization, Properties, Applications, and Modelling offers comprehensive information on the various types of polymeric adsorbents and uses, enabling the reader to understand, identify and prepare adsorbents with the required structure and properties for a range of key industrial applications. The book presents the various types of polymeric adsorbents and their characteristics, focuses on physicochemical properties, synthesis methods, functionalization, and composites and hybrid materials, and highlights key application areas, including gas adsorption, heavy metal removal, hazardous dye removal, and adsorption of antibiotics. Finally, the book provides detailed guidance on modeling of polymeric adsorbent behavior and molecular dynamic (MD) simulation. This is a valuable resource to researchers and advanced students across polymer science, chemistry, materials science, engineering, environmental science, and engineers, scientists, and R&D professionals with an interest in polymeric adsorbents for industrial applications.
The Wool Handbook: Morphology, Structure, Property and Applications explores the fundamental aspects of wool fibers as well as traditional and novel applications of wool in areas including polymer composites and technical textiles. Apart from textiles and garments, wool has long been used for various diversified applications due to its unique material properties. Wool is inherently fire resistant, antimicrobial, flexible and antibacterial, and as a natural material, it can be used to create environmentally sustainable products. This book explains basic and advanced topics related to wool fibers, from shearing to marketing, drawing on academic and industrial research from a range of subjects. Providing statistics, processing methods, and testing and characterization techniques for wool fiber, this book will help readers to use wool fibers to find new applications and solutions.
Titan After Cassini-Huygens is the most up-to-date and comprehensive coverage of our knowledge on Titan, including results and insights from the joint NASA/European Space Agency/Italian Space Agency mission Cassini-Huygens and the conclusions drawn by experts following detailed analysis of the mission data. Our knowledge of Titan has increased substantially due to observations from the Cassini-Huygens mission, which ended in 2017. Since then, observations from Earth, as well as laboratory and theoretical studies, have continued to add to our knowledge. These conclusions, combined with the latest ground-based and theoretical research, provide the most recent understanding of the science of Titan, covering the origin and evolution of Titan, its magnetic and plasma environment, surface, interior structure, geology, atmosphere, and the astrobiological potential for the oceans on the moon.The first book of the new COSPAR book series, Titan After Cassini-Huygens, is an integral reference for scientists, researchers, and academics working on Titan or ocean worlds. Part of the COSPAR Book SeriesEdited by Jean-Louis Fellous, former Executive Director of COSPAR (Committee on Space Research; 2008-2019)
Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1.The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets.
Practical Aspects of Electroorganic Synthesis presents an educational insight into the practical aspects of electrosynthesis methods by providing a variety of examples and techniques. With the advancement of chemical science and its undeniable role in life, there is a growing need for the employment of green and eco-friendly methods and environmentally acceptable processes to minimize the negative consequences of chemical technologies. These needs and concepts are referred to as "green chemistry? and "sustainable technology?. Electrosynthesis techniques are an example of one of the notable achievements of the interdisciplinary co-operation that assists in minimizing these consequences. This book comprises three fundamental sections: direct, indirect, and paired electrolysis. As a result, this logically separates the key information needed to conduct electrochemistry into digestible and rational parts. Direct electrolysis discusses anodic oxidation, cathodic reduction, mechanistic studies (cyclic voltammetry), and how to set up electrochemical experiments. Indirect electrolysis proceeds to explore catalysts and additives in more depth to take on modern electrochemical methods. Finally, this book explores the burgeoning new field of paired electrolysis, in which the ultimate green-synthesis applications are possible, with no wasted electrons and very few by-products. Practical Aspects of Electroorganic Synthesis offers researchers a modern and authoritative resource that brings complete and up-to-date practical concepts of electrosynthesis methods and guides the audience on how to carry out a large number of experimental techniques.
Modern Manufacturing Processes for Aircraft Materials presents a detailed review of advanced manufacturing processes exclusively used for aircraft materials, including metals, polymers and composites. Advanced manufacturing methods are discussed as well as recent non-conventional manufacturing methods for aircraft-specific materials. Key important processes discussed include additive manufacturing for both polymeric and metallic materials, electrical discharge machining, laser welding, electron beam welding, and micro-machining. In addition to the theoretical discussion, various examples of case studies are presented from reputable research centers, and institutes.This will be a valuable reference resource for academic researchers, materials scientists, and industrial engineers working in manufacturing of advanced materials for the aircraft industry.
Mechanoluminescence in Organic and Inorganic Compounds: Basic Concepts, Instrumentation, and Applications provides a comprehensive overview of mechanoluminescence for newly qualified researchers and scientists across multiple related fields. It serves as a guide for budding scientists to advance in the field through various applications covered in this book, such as energy, mechanics, medicine, and optics. This reference shines light on the pros and cons of utilizing organic or inorganic mechanoluminescent materials, making it a handy tool for researchers worldwide involved in luminescence and applications such as optoelectronics, sensors, forensics, displays, energy harvesting, and smart robotics. The editors and their expert contributors summarize these applications, making it a valuable resource for academics, researchers, and those working in industry.Mechanoluminescence in Organic and Inorganic Compounds contains broad coverage, which progresses from theory to applications, serves as a complete reference of global research and experience, which will work to inform and guide the development of more efficient devices for the future.
Oxygen, Nitrogen and Sulfur Species in Post-harvest Physiology of Horticultural Crops, a volume in the Plant Gasotransmitter series, analyzes the latest advances in post-harvest physiology. The book presents metabolic cascades and highlights the role of gasotransmitters as intercellular regulators of metabolic processes. Post-harvest physiology differs between climacteric and non-climacteric fruits and vegetables, as well as for fresh-cut flowers and non-food plants. Initial chapters review the cascades, intercellular pathways and messenger molecules that drive ripeness and longevity, presenting the chemistry behind key pathways. The books also takes a deep dive into core gasotransmitters, describing the data behind known properties, chemistry and physiological roles. Applications for prolonging shelf-life via the control of post-harvest fungi, bacteria and omics approaches are reviewed in detail, offering readers guidance on how to put gasotransmitters research into practice. This is an essential resource for students, researchers and agronomists interested in plant physiology, biochemistry and plant hormones.
Prenumerera på vårt nyhetsbrev för att få fantastiska erbjudanden och inspiration för din nästa läsning.
Genom att registrera dig accepterar du vår personuppgiftspolicy.
