Böcker utgivna av Elsevier Science & Technology

Brillouin Scattering, Part Two, Volume 110 in the Semiconductors and Semimetal series, marks the centenary of Leon Brillouin''s seminal 1922 paper which provided a detailed theory on the effect that now bears his name. Sections in this new release include Optical Fiber Sensors Based on Stimulated Brillouin scattering, Brillouin-based RF frequency sources, SBS for Microwave Photonics (MWP), Engineerable Brillouin processes for integrated photonics, SBS in optical communication systems - the good, the bad and the ugly, Slow light, dynamic gratings and light storage, Non-reciprocity in Brillouin scattering, Electromechanical Brillouin Scattering, and Brillouin light scattering for studying mechanics of biological systems. Stimulated Brillouin Scattering (SBS) is the strongest third order nonlinearity and plays an important role in contemporary science and applications, particularly lasers, communications, fiber optics and basic physics. This volume provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage. Presented by the leading researchers in the field Covers both scientific and technological perspectives Provides different perspectives on current technological contexts of SBS in a range of different application areas, including sensing, communications, radar, imaging and information storage

Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 61 presents the latest release in this continuous series that covers all aspects of rare earth science, including chemistry, life sciences, materials science and physics. Presents up-to-date overviews and new developments in the field of rare earths, covering both their physics and chemistry Contains individual chapters that are comprehensive and broad, along with critical reviews Provides contributions from highly experienced, invited experts

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review on Neurobiology serials Updated release includes the latest information on Sex and Gender Differences in Neurological Disease

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

This volume addresses key contemporary aspects in cycling policy, practice and research. Cycling has seen a sharp increase in scientific and policy attention in the past decade. The amount of research has surged over the past couple decades. Also, levels of cycling have increased substantially in many countries and cities, and many areas have seen increases in infrastructure investments. In addition, the last decade has seen innovations in bicycle technology, in particularly the rise of electric-assist (e-bikes) and dock-less bike sharing schemes. This volume reviews the state of the art on cycling from various angles. As such it explores planners'' (engineers'', policy makers'') provisions for cycling, of cyclists'' (and non-cyclists'') travel behaviour, and resulting consequences for individuals and society. One focus is on demand-side aspects, including the use of bicycles and their users including patterns and trends in cycling, determinants of cycling, and modelling of cycling. Another focus is on impacts of cycling, such as emissions, safety aspects, as well as changes during the COVID pandemic. Contemporary overview of key aspects in cycling research and bicycle planning A focus on design for cycling, behavior of cyclists and consequences of cycling

Power Generation Technologies: Foundations, Design and Advances provides a comprehensive introduction to the latest developments in renewable and non-renewable generation technologies considered at micro and large-scale, and for traditional facility scale and modern distributed power generation systems. Each chapter provides a foundation in the topic enriched with practical solved examples, end chapter exercises and technical references. Provided computer codes can be instrumentalized to investigate practical examples at a granular level. In addition to the fundamental and theoretical discussions, operational and maintenance guidelines for power equipment are provided to prepare students for work in power plants. The work provides new international standards and regulation for power generation as well as content devoted to the thermo-economics of power generation and power plants. It is supported by a solution manual for end-chapter exercises and a slide show presentation of the book for instructors and students.

Agricultural Soil Sustainability and Carbon Management presents long-term research in the field of sustainable soil use and management to guide in the prioritizing the multifunctional value of soil health and addressing interdisciplinary links between major issues such as biodiversity and climate change. As soil is the largest terrestrial carbon pool and a significant contributor of greenhouse gases, much progress can be made toward curtailing the climate crisis by sustainable soil management practices. The book provides valuable insight into the soil and carbon management, research gaps, and the methodological challenges for research into soil carbon management that will be important over the decades.

Nuclear Power Reactor Designs: From History to Advances analyzes nuclear designs throughout history and explains how each of those has helped to shape and inform the nuclear reactor designs of today and the future. Focused on the structure, systems and relevant components of each reactor design, this book provides the readers with answers to key questions to help them understand the benefits of each design. Each reactor design is introduced, their origin defined, and the relevant research presented before an analysis of its successes, what was learned, and how research and technology advanced as a result are presented. Students, researchers and early career engineers will gain a solid understanding of how nuclear designs have evolved, and how they will continue to develop in the future.

Aptamers for Food Applications: Safety, Authenticity, and Integrity outlines the main applications of aptamers to ensure food safety, quality and compliance that are crucial for food science, public health and human sustainability. Aptamers or aptamer-based analytical devices are comprehensively summarized to tackle various food contamination or food adulteration problems. Topics covered in this book include aptamers for foodborne microbial pathogens, pesticide or veterinary drug residues, heavy metals, biotoxins, abused food additives, illegal food adulterants, POPs, GMOs, food allergens and food contact material migrants. It is therefore of interest for not only analytical investigators and food safety inspectors, but also regulatory practitioners and risk assessors in various food science and research fields.

Building off the success of the first edition, Gut Microbiota: Interactive Effects on Nutrition and Health, Second Edition, details the complex relationship between diet, the gut microbiota, and health. This second edition expands its coverage of emerging practical applications in nutrition and medicine. Covering topics such as the ecological concepts that apply to the gut microbiota and the effects of aging on the gut microbiome, among others, this book is sure to be a welcome resource to microbiome science trainees, food and nutrition researchers working in academia, and industry and healthcare professionals giving dietary recommendations to the general public.

Handbook of Child and Adolescent Psychology Treatment Modules: Personalized Care in Behavior and Emotion provides clinicians with modularized treatment strategies for commonly occurring child and youth mental health disorders. Divided into two sections, the first part of the book translates basic science into clinical practice, reviewing predictors, mediators and moderators of change, and an overview of evidence for best practices in treating disorders. The second section guides clinicians on how to implement treatment strategies. Chapters instruct what therapy is, how to introduce it to clients, step-by-step implementation, worksheets for use in practice, homework to send home with clients, and more.

Deprescribing and Polypharmacy in an Aging Population supports healthcare professionals across global healthcare institutions in reducing polypharmacy-related drug replated problems (DRPs) by working with patients, families, interprofessional healthcare professionals, and educational institutions to develop, implement, test, improve upon, and educate on strategies for deprescribing and optimizing patient safety. Polypharmacy, the use of multiple medications at the same time by one person, is very common in various patient populations, including those who lack primary physicians, patients with mental health conditions, patients with multiple chronic conditions, and in the aging population.

Distributed Computing to Blockchain: Architecture, Technology, and Applications provides researchers, computer scientists, and data scientists with a comprehensive and applied reference covering the evolution of distributed systems computing into blockchain and associated systems. Divided into three major sections, the book explores the basic topics in the blockchain space extending from distributed systems architecture, distributed ledger, decentralized web to introductory aspects of cryptoeconomics (cryptography and economics) of decentralized applications. The book further explores advanced concepts such as smart contracts; distributed token mining, initial coin offerings; proof of work; public, private, and other blockchains; cryptography; security; and blockchains. The book goes on to review byzantine fault tolerance, distributed ledgers versus blockchains, and blockchain protocols. The final section covers multiple use cases and applications of distributed computing and the future directions for blockchains.

Membrane Dehumidification and Cooling: Fundamentals and Applications presents the state-of-the-art on membrane dehumidifiers, highlighting their most recent advancements and providing key insights into global R&D interests. With a strong focus on applications, the book offers characterization techniques to evaluate the potential of hygroscopic materials, as well as experimental methods to study the dehumidifiers' performance. The book begins by highlighting the demerits of conventional cooling systems and then reviews electrically driven alternative cooling solutions. A comparative study between different dehumidification techniques is also given, along with sections on fundamental transport mechanisms and thermodynamic modeling. Finally, scaling, heat transfer and thermodynamic analysis are presented, along with a review of hybrid membrane-based air-conditioners. This book is a one-stop resource for recent advancements in membrane dehumidification and cooling applications. It is an essential read for students, researchers and engineers interested in thermal engineering, heat and mass transfer, alternative cooling, energy materials and dehumidification.

Handbook of Organizational Creativity: Individual and Group Level Influences, Second Edition covers creativity from many perspectives in two unique volumes, including artificial Intelligence work, creativity within specific applied domains (e.g., engineering, science, therapy), and coverage of leadership. The book includes individual, team and organizational level factors and includes organizational interventions to facilitate creativity (such as training). Chapters focus on creative abilities and creative problem-solving processes, along with individual differences such as motivation, affect and personality. New chapters include the neuroscience of creativity, creativity and meaning, morality/ethicality and creativity, and creative self-beliefs. Sections on group level phenomena examine team cognition, team social processes, team diversity, social networks, and multi-team systems and creativity. Final coverages includes different types and approaches to leadership, such as transformational leadership, ambidextrous leadership leader-follower relations, and more.

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion. Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine.

Fundamentals of Data Science: Theory and Practice presents basic and advanced concepts in data science along with real-life applications. The book provides students, researchers and professionals at different levels a good understanding of the concepts of data science, machine learning, data mining and analytics. Users will find the authors' research experiences and achievements in data science applications, along with in-depth discussions on topics that are essential for data science projects, including pre-processing, that is carried out before applying predictive and descriptive data analysis tasks and proximity measures for numeric, categorical and mixed-type data. The book's authors include a systematic presentation of many predictive and descriptive learning algorithms, including recent developments that have successfully handled large datasets with high accuracy. In addition, a number of descriptive learning tasks are included.

Hemostasis Management of the Pediatric Surgical Patient provides knowledge on the emerging area of pediatric hemostasis and its management. It discusses aspects of perioperative blood management in the pediatric population, including how to accurately estimate and monitor bleeding and determine optimal treatment regimens for bleeding in pediatric surgical patients. It also provides information on the implementation of intraoperative blood conservation strategies, goal-directed transfusion therapy, and postoperative estimation of bleeding and thrombotic risks. This book is a valuable resource to pediatric practitioners and researchers who need comprehensive information on pediatric hematology, from basic physiology to pre-, intra- and postoperative care of pediatric patients. The coagulation system of children evolves with age as evidenced by marked physiological differences in the concentration of hemostatic proteins between children of different age groups and adults. Consequently, there are distinct differences in hemostatic management between adult and pediatric patients.

Artificial Intelligence in Healthcare and COVID-19 showcases theoretical concepts and implementational and research perspectives surrounding AI. The book addresses both medical and technological visions, making it even more applied. With the advent of COVID-19, it is obvious that leading universities and medical schools must include these topics and case studies in their usual courses of health informatics to keep up with the pace of technological and medical advancements. This book will also serve professors teaching courses and industry practitioners and professionals working in the R&D team of leading medical and informatics companies who want to embrace AI and eHealth to fight COVID-19. Since AI in healthcare is a comparatively new field, there exists a vacuum of literature in this field, especially when applied to COVID-19. With the area of AI in COVID-19 being quite young, students and researchers usually face a struggle to rely on the few published papers (which are obviously too specific) or whitepapers by tech-giants (which are too wide).

Snow Leopards, Second Edition provides a foundational, comprehensive overview of the biology, ecology and conservation of this iconic species. This updated edition incorporates all the recent information from range-wide surveys and conservation projects, the results of technical and advances particularly in genetics, camera trapping and satellite tracking, and evaluates emerging threats. New chapters synthesize the novel scientific methods and statistical analyses used to develop density and population estimates and how they inform conservation and management estimates. Sections cover historical information, the main biogeographic patterns, evolutionary trends, conservational efforts, and cultural significance. Status and distribution are fully updated for all 12 countries where snow leopards occur. Other sections describe established and emerging threats, including human-wildlife conflict, illegal trade, infrastructure development, and climate change along with conservation solutions used to address these threats. The book concludes with a final section on global snow leopard initiatives and future potentials.

"Making a Collection Count, A Holistic Approach to Library Collection Management, Third Edition is unique in its focus on collection quality, including topics on making the most of a library collection budget, performing physical inventory, and gathering/using data and statistics about collection use. Beyond collection development, this title looks at the entire lifecycle of the collection and those with responsibilities at each step" --

AI Computing Systems: An Application Driven Perspective adopts the principle of "application-driven, full-stack penetration" and uses the specific intelligent application of "image style migration" to provide students with a sound starting place to learn. This approach enables readers to obtain a full view of the AI computing system. A complete intelligent computing system involves many aspects such as processing chip, system structure, programming environment, software, etc., making it a difficult topic to master in a short time.

Microbiome and the Eye: What's the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases.

Glycoside Hydrolases provides a detailed overview of the biochemical, biophysical, and protein engineering properties of glycoside hydrolases, a class of enzymes in growing use across various applications. Here, more than a dozen global experts discuss the structural and catalytic mechanisms of specific glycoside hydrolases, followed by their implications in biotechnological applications of different industrial sectors such as the food and feed industry, paper and pulp industry, the bioenergy sector and the pharmaceutical industry. Authors consider how the application of glycoside hydrolases may boost industrial production of valued products, and the broader environmental and sustainability goals of converting agrowaste into valued products. This book helps researchers and students across industry and academia gain deep knowledge of glycoside hydrolases, to advance new experimental research and applications from biofuel to drug discovery.

Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases-enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. This book covers all aspects of this enzymatic class starting with foundational overview and then providing historical urease research and current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed.The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered.

Building Energy Flexibility and Demand Management looks at the high penetration of intermittent renewable energy sources and the need for increased flexibility. Ensuring electrical power systems adapt to dynamic energy demand and supply conditions, the book supports the transition to a renewable energy future with current fluctuating power generation. By facilitating the penetration of renewable energy sources into the building sector and balancing electricity supply with demand in real-time, this book will provide fundamental concepts, theories, and methods to understand, quantify, design and optimize building energy flexibility. In addition, the book also provides case studies with emerging technologies to enhance building energy flexibility and demonstrate how demand management strategies can utilize energy flexibility for demand reduction and load shifting. It will be useful for all those researchers and engineers working in flexible energy systems and advanced demand side management strategies.

Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource. This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity.

Ethics for Health Promotion and Health Education discusses ethical principles and interpretations by classical ethicists as they apply to health promotion and health education. The book unpacks ethical expectations in promoting and teaching health in both the classroom and as a researcher or practitioner and then applies the code of ethics using case study methods throughout. This informative text was written by health educators and practitioners to assist health educator and practitioner communities.