Böcker utgivna av Elsevier Science & Technology

Practical Biostatistics: A Friendly Step-by-Step Approach for Evidence-Based Medicine, now in an updated second edition, presents a complete resource of biostatistical knowledge meant for health sciences students and researchers, as well as health care professionals. Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making using statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards, and they can find all the relevant information to achieve their goals in this book. The content is split into 5 sections: the investigator''s hypothesis; collective health; observational studies; biostatistics of intervention studies - the clinical trials; and additional concepts in biostatistics. The chapters are written in a didactic way to make them easier to comprehend by readers with little or no background on statistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials and research projects. Explains biostatistics in a didactic way for students, researchers and professionals of health sciences with little or no background on mathematics, tailored for their specific needsPresents a new section dedicated to epidemiology and public health, broadening the content from the previous editionWritten by medical doctors with vast experience on biostatistics and teaching, developing the content based on real cases for better applicability by readers

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.Offers a basic understanding and clear picture of genome editing CRISPR-Cas systems in different organismsExplains how to create an animal model for disease diagnosis/research and reprogram CRISPR for removal of virus, bacteria, fungi, protozoan, and many moreDiscusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, and many more

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Advances in Stem Cells and their Niches seriesIncludes the latest information on the Cancer Stem Cell Niche

What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal''s decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more. Comprises the perspectives of a diverse array of world-leading researchers in medial frontal cortex functionProvides the latest theoretical and data-based evidence for the function of medial frontal cortexPresents the importance of systems-based neuroscience approaches to the understanding of medial frontal cortex function

Agricultural Waste Diversity and Sustainability Issues: Sub Saharan Africa as Case Study presents solutions for overcoming limitations, guiding developmental processes, and improving knowledge transfer in agricultural waste management and development. The book gives considerable attention to treatment and conversion, with best management practices involving the reduction and elimination of waste volume in its various forms, sectors and streams. Sections cover waste management in the agriculture and food sector, including methodological approaches in waste preparation and processes, the most important energy generation techniques and strategies, and best practices, management, sustainability, associated technologies, accountability, communications, and involvement surrounding diverse stakeholders. Finally, the book illustrates the use of mathematical models to minimize operational cost in agro-waste management processes and discusses the application of eco-efficiency. Ultimately, the book focuses on the prospect of agro-wastes management and risk associated in the sub-Saharan African region, including Nigeria, Uganda and South Africa as case studies.Captures a solutions-based assessment that redresses the challenges created by a poor biodiversity strategy in Sub-Saharan Africa to meet present needs in SSA and around the worldProvides foundational information for agricultural diversity, food waste elimination, clean energy production, and technology emergenceEnables a greater understanding of the state-of-the-art approach for effective biodegradable waste managementInspires further research into sustainable and cost-effective biowaste operations, wastes management models, methodologies for utilization and nascent technologies that are capable of bolstering clean energy generation

Metal Forming: Formability, Simulation, and Tool Design focuses on metal formability, finite element modeling, and tool design, providing readers with an integrated overview of the theory, experimentation and practice of metal forming. The book includes formability and finite element topics, including insights on plastic instability, necking, nucleation and coalescence of voids. Chapters discuss the finite element method, including its accuracy, reliability and validity and finite element flow formulation, helping readers understand finite element formulations, iterative solution methods, friction and contact between objects, and other factors. The book''s final sections discuss tool design for cold, warm and hot forming processes. Examples of tools, design guidelines, and information related to tool materials, lubricants, finishes, and tool failure are included as well.Provides fundamental, integrated knowledge on metal formability, finite element topics and tool designOutlines user perspectives on accuracy, reliability and validity of finite element modelingDiscusses examples of tools, their design guidelines, tool lubricants, and tool failureConsiders the role played by stress triaxiality and shear and introduces uncoupled ductile damage criteriaIncludes applications, worked examples and detailed techniques

Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.Provides up-to-date and extensive reviews of different aspects of celiac disease pathogenesisIncludes original figures that help readers understand the complex pathways involved in the diseaseCovers research on different aspects of the disease which involves the introduction of a wide range of technologies

Electronic Devices, Circuits, and Systems for Biomedical Applications: Challenges and Intelligent Approaches explains the latest information on the design of new technological solutions for low-power, high-speed efficient biomedical devices, circuits and systems. The book outlines new methods to enhance system performance, provides key parameters to explore the electronic devices and circuit biomedical applications, and discusses innovative materials that improve device performance, even for those with smaller dimensions and lower costs. This book is ideal for graduate students in biomedical engineering and medical informatics, biomedical engineers, medical device designers, and researchers in signal processing.Presents major design challenges and research potential in biomedical systemsWalks readers through essential concepts in advanced biomedical system designFocuses on healthcare system design for low power-efficient and highly-secured biomedical electronics

Catalysis in Biomass Conversion, Volume 77 in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Advances in Inorganic Chemistry series

Machine Learning Guide for Oil and Gas Using Python: A Step-by-Step Breakdown with Data, Algorithms, Codes, and Applications delivers a critical training and resource tool to help engineers understand machine learning theory and practice, specifically referencing use cases in oil and gas. The reference moves from explaining how Python works to step-by-step examples of utilization in various oil and gas scenarios, such as well testing, shale reservoirs and production optimization. Petroleum engineers are quickly applying machine learning techniques to their data challenges, but there is a lack of references beyond the math or heavy theory of machine learning. Machine Learning Guide for Oil and Gas Using Python details the open-source tool Python by explaining how it works at an introductory level then bridging into how to apply the algorithms into different oil and gas scenarios. While similar resources are often too mathematical, this book balances theory with applications, including use cases that help solve different oil and gas data challenges.Helps readers understand how open-source Python can be utilized in practical oil and gas challenges Covers the most commonly used algorithms for both supervised and unsupervised learningPresents a balanced approach of both theory and practicality while progressing from introductory to advanced analytical techniques

There is a growing need for better membranes in several emerging application fields especially those related to energy conversion and storage as well as to water treatment and recycling. Processability, is an important functional property, often ignored, especially in the early discovery phase for new materials, but it should be one of the most important properties, that needs to be considered in the development of better membrane materials. Useful membrane materials have to be capable of being formed into thin membranes, in particular for membrane gas separation, water treatment and desalination, and then packaged, into large area membrane modules. All gas separation membranes that are in current commercial use are based on polymers, which are solution-processable. This book intends to deal with composite, in most cases hybrid polymer-based membranes for three separate application fields: energy conversion, energy storage and water treatment and recovery. Each chapter will explain clearly the various membrane processes then go on to discuss in detail the corresponding advanced membranes used. The logic that lies behind this is that you have to understand the process in order to develop new high-performance membranes. By taking this approach, the author aims to overcome the disconnection that currently exists between membrane materials scientists and industrial process engineers. Discusses interdisciplinary content by a single author, approaching synthesis and development of materials from the perspective of their processability Describes the novel aspects of membrane science that is related to energy storage, conversion and wastewater treatment Presents an emphasis on scientific results which have an impact on real applications in terms of renewable and clean energy challenges

Unconventional reservoirs of oil and gas represent a huge additional global source of fossil fuels. This book provides the reader with an understandable overview of the chemistry and engineering behind the developments and technologies in the industry as well as the various environmental regulations.

Introduction to Deep Learning and Neural Networks with Python¿: A Practical Guide is an intensive step-by-step guide for neuroscientists to fully understand, practice, and build neural networks. Providing math and Python¿ code examples to clarify neural network calculations, by book¿s end readers will fully understand how neural networks work starting from the simplest model Y=X and building from scratch. Details and explanations are provided on how a generic gradient descent algorithm works based on mathematical and Python¿ examples, teaching you how to use the gradient descent algorithm to manually perform all calculations in both the forward and backward passes of training a neural network.

As conventional-oil resources are depleted worldwide, vast heavy oil reserves available in various parts of the world become increasingly important as a secure future energy source. This title discusses the improvements in production processes including; thermal methods as well as non-thermal methods.

Offers practical advice on breaking down the implementation and deployment of voice mobility networks within the office, across the campus, and on the road. This title includes methods of integrating VoIP networks with 3G+, CDMA 2000, WCDMA, HSPA, and WiMAX cellular networks using fixed/mobile convergence (FMC).

Provides tutelage for data modelers, business analysts and systems designers at various levels. Beginning with the basics, this book provides a grounding in theory before guiding the reader through the various stages of applied data modeling and database design. It addresses advanced subjects such as business rules, data warehousing, and others.

Reviews flow techniques for automating chemical analysis with the goal of increasing efficiency and producing better analytical results. This book focuses on fresh trends in the field such as using flow techniques for radioactivity and environmental applications.

Describes the principles, equipment, and applications involved in sample preparation with microwaves for trace element analysis. This book covers applications as well as fresh trends in this field. It discusses topics such as: sample preparation for speciation, metabolomics, and halogen determination.

Covering subjects from corporate taxes to behavioral corporate finance and econometric issues, this title includes articles that reveal how specializations resonate with each other and indicate likely directions for future research. It presents coherent summaries of major finance fields, marking important advances and revisions.

Corrosion in nuclear power plants cause reductions in efficiency and increases in deposit build-up on plant surfaces, making for expensive maintenance and potential radiological health hazards. This book guides studies to predict and minimize corrosion, thus making nuclear power safer and cost effective.