Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice.
After more than 30 years, The Book of Fructans represents the first and most comprehensive coverage of fructans generated by pioneer glycoscientists from the field. It outlines the fundamentals of all fructan types, their terminology, chemical and structural-functional features, biosynthetic enzymes that make and break them, their presence and possible roles in nature, their evolutionary aspects and their microbial, enzymatic, and plant-based production. Additional sections cover the applications of fructans, specifically, the agro/chemical and biomedical applications, health, pharmaceutical and cosmetic applications, fructans in food and feed, fructan nanotechnology, the immunomodulatory and antiviral effects of fructans and the perspectives for fructans in circular economies and sustainable societies. Intended for scientists, entrepreneurs, academicians and students working in related fields, this book will be a useful resource for all who wish to learn more about these extraordinary carbohydrates.
Provides information on basic and applied aspects of biofuels production from algae. This book covers topics such as metabolic engineering and molecular biology for algae for fuel production, life cycle assessment and scale-up and commercialization.
Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.
Sustainable Oil and Gas Development Series: Reservoir Development delivers research materials and emerging technologies that conform sustainability in today's reservoirs. Starting with a status of technologies available, the reference describes sustainability as it applies to fracturing fluids, particularly within unconventional reservoirs. Basement reservoirs are discussed along with non-energy applications of fluids. Sustainability considerations for reserve predication are covered followed by risk analysis and scaling guidelines for further field development. Rounding out with conclusions and remaining challenges, Sustainable Oil and Gas Development Series: Reservoir Development gives today and future petroleum engineers a focused and balanced path to strengthen sustainability practices.
Recent advances in renewable energy technologies is a comprehensive reference based on the International Renewable Energy Congress (IREC) covering critical research and industry developments on renewable energy technological, production, conversion, storage and management. Covering solar energy system (thermal and photovoltaic), wind energy, hydropower, geothermal energy, bioenergy production and hydrogen production, large scale development of these renewable energy technologies and their impact on global economy and power capacity. The technology advancements include resources assessment and deployment, materials performance improvement, system optimization and sizing, instrumentation and control, modelling and simulation, regulations and policies. Each modular chapter examines recent advances in specific renewable energy systems, providing theoretical and applied aspects of system optimization, control and management and supports them with global case studies demonstrating practical applications and economical and environmental aspects through life cycle analysis. The book is of interest to engineering graduates, researchers, professors and industry professionals involved in the renewable energy sector and advanced engineering courses dealing with renewable energy, sources, thermal and electrical energy production and sustainability. Addresses the advantages and disadvantages of all renewable technologies Includes global case studies demonstrating practical applications of renewable energy production and distribution Features video and slideshows in the online e-book for application tutorials
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology
Information Physics: Physics-Information and Quantum Analogies for Complex Modelling presents a new theory of complex systems that uses analogy across various aspects of physics, including electronics, magnetic circuits and quantum mechanics. The book explains the quantum approach to system theory that can be understood as an extension of classical system models. The main idea is that in many complex systems there are incomplete pieces of overlapping information that must be strung together to find the most consistent model. This incomplete information can be understood as a set of non-exclusive observer results. Because they are non-exclusive, each observer registers different pictures of reality.Provides readers with an understanding of the analogies between very sophisticated theories of electrical circuits and currently underdeveloped information circuits, including capturing positive and negative links, as well as serial and parallel ordering of information blocksIntegrates coverage of quantum models of complex systems using wave probabilistic functions which extend the classical probability description by phase parameters that allow researchers to model such properties as entanglement, superposition and othersProvides readers with illustrative examples of how to use the presented theories of complex systems in specific cases such as hierarchical systems, cooperation of a team of experts, the lifecycle of the company, and the link between short and long-term memory
Neurocognitive Mechanisms of Attention: Computational Models, Physiology, and Disease States describes the brain mechanisms underlying the attention control system, how those mechanisms are examined, how they operate in different disease states, and methods for improving them. Conceptual models of attention further explore their functional operation. Coverage includes the different types of attention, processing paths, brain anatomy, and attention¿s role in memory and movement. Factors affecting attention are explored including nutrition, exercise, and genetics. Neurocognitive disorders impacting attention are discussed including autism, ADHD, OCD, depression, anxiety, schizophrenia, Alzheimer¿s and Parkinson¿s Disease. Assessment methods and treatments are uniquely set against the backdrop of current conceptual, computational, and oscillatory-based models to encourage researchers to pursue continued development of new diagnostic and therapeutic tools.
Integrated Population Models: Theory and Ecological Applications with R and JAGS is the first book on integrated population models, which constitute a powerful framework for combining multiple data sets from the population and the individual levels to estimate demographic parameters, and population size and trends. These models identify drivers of population dynamics and forecast the composition and trajectory of a population. Written by two population ecologists with expertise on integrated population modeling, this book provides a comprehensive synthesis of the relevant theory of integrated population models with an extensive overview of practical applications, using Bayesian methods by means of case studies. The book contains fully-documented, complete code for fitting all models in the free software, R and JAGS. It also includes all required code for pre- and post-model-fitting analysis. Integrated Population Models is an invaluable reference for researchers and practitioners involved in population analysis, and for graduate-level students in ecology, conservation biology, wildlife management, and related fields. The text is ideal for self-study and advanced graduate-level courses.
Understanding the evolution and advances of energy conversion is critical to meet today''s energy demands while lowering emissions in the fight against climate change. One advancement within nuclear plants that continues to gain interest is molten salt reactors and integrated molten salt reactors, which are the new proposed generation IV small modular reactors. To get up to speed on the latest technology, Molten Salt Reactors and Integrated Molten Salt Reactors: Integrated Power Conversion delivers a critical reference covering the main steps for the application of these reactors. Creating a more environmentally friendly energy production methodology, the reference reviews the past, current, and future states of the reactors including pros and cons, designs and safety features involved, and additional references. Included in the reference is a new approach to energy conversion technology, including coverage on material, economic, and technical challenges towards waste heat recovery, power conversion systems, and advanced computational materials proposed for generation IV systems. Advanced nuclear open air-brayton cycles are also included for higher efficiency. Rounding out with guidance on avoiding salt freezing and salt cleanup for fission and fusion reactors, Molten Salt Reactors and Integrated Molten Salt Reactors: Integrated Power Conversion provides today''s nuclear engineer and power plant engineer with the impactful content of rising efficiency in molten salt reactors, ultimately leading to more efficient and affordable electricity.Gain the latest applications and steps to implement modular reactors, including safety and technical considerationsLearn an innovative approach to nuclear air combined cycles (NACC), bringing down the costs of producing electricity in nuclear power plantsPractice techniques and computer modeling with additional appendices that include experimental validation methods and computer code results
Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.
Multilevel Inverters: Control Methods and Power Electronics Applications provides a suite of powerful control methods for conventional and emerging inverter topologies instrumentalized in power electronics applications. It introduces readers to the conventional pulse width modulation control of multilevel voltage source inverter topologies before moving through more advanced approaches including hysteresis control, proportional resonance control, and model predictive control. Later chapters survey the power electronics connection between device topologies and control methods, particularly focusing on conversion in renewable energy systems, electric vehicles, static VAR compensators and solid-state transformers.Examines modern design configurations for multilevel inverter controllers, emerging control methods, and their applicationsPresents detailed application examples of multilevel inverters deployed in modern and recent power electronic areas including renewable energy sources, electric vehicles, and grid managementDiscusses deployment and development of future power converter implementation
Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.Draws on the strongest aspects of polar positions in philosophy and psychiatry to help resolve important perennial debates in these fieldsExplores continuities between early philosophical work and current cognitive-affective sciences, including neuroscience and psychologyEmploys findings from modern cognitive-affective science to rethink key long-standing debates in philosophy and psychiatryBuilds on work showing how mind is embodied in the brain, and embedded in society, to provide an integrated conceptual frameworkAssesses both the insights and the limitations of cognitive-affective science for addressing the big questions and hard problems of living
Principles and Labs for Deep Learning provides the knowledge and techniques needed to help readers design and develop deep learning models. Deep Learning techniques are introduced through theory, comprehensively illustrated, explained through the TensorFlow source code examples, and analyzed through the visualization of results. The structured methods and labs provided by Dr. Huang and Dr. Le enable readers to become proficient in TensorFlow to build deep Convolutional Neural Networks (CNNs) through custom APIs, high-level Keras APIs, Keras Applications, and TensorFlow Hub. Each chapter has one corresponding Lab with step-by-step instruction to help the reader practice and accomplish a specific learning outcome. Deep Learning has been successfully applied in diverse fields such as computer vision, audio processing, robotics, natural language processing, bioinformatics and chemistry. Because of the huge scope of knowledge in Deep Learning, a lot of time is required to understand and deploy useful, working applications, hence the importance of this new resource. Both theory lessons and experiments are included in each chapter to introduce the techniques and provide source code examples to practice using them. All Labs for this book are placed on GitHub to facilitate the download. The book is written based on the assumption that the reader knows basic Python for programming and basic Machine Learning.Introduces readers to the usefulness of neural networks and Deep Learning methodsProvides readers with in-depth understanding of the architecture and operation of Deep Convolutional Neural NetworksDemonstrates the visualization needed for designing neural networksProvides readers with an in-depth understanding of regression problems, binary classification problems, multi-category classification problems, Variational Auto-Encoder, Generative Adversarial Network, and Object detection
Advances in Parasitology, Volume 112, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticercosis, Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.Informs and updates on all the latest developments in the field of parasitologyIncludes medical studies of parasites of major influenceFeatures reviews of more traditional areas, such as zoology, taxonomy, and life history, which help shape current thinking and applications
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