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In recent times, the boundary between living and non-living has been blurred by advances in genomics, cell biology, and molecular neuroscience, whereby humans are repaired, enhanced, or made anew. Scientists and physicians are now able to keep cells, organs, and bodies alive indefinitely and can return cells or DNA to our bodies and make new cells for the purpose of treating disease or growing new tissue. Meanwhile, transhuman technologies create illusions of immortality. Immortal: Our Cells, DNA, and Bodies synthesizes what we know about life and death from a genetic, molecular, and cellular perspective, demarcates limits of knowledge, and poses new questions. Award-winning researcher and writer David Goldman examines in-depth three keys to understanding the nature and continuity of life: 1) epigenetic (ephemeral) vs genetic (durable) transgenerational memory; 2) life¿s cellular nature, and the ability to make bodies from cells; and 3) the distinction between bodies and persons. Grounded in recent scientific evidence and real-life cases that test our historical understanding of life and death, Goldman probes the nature of molecular continuity in the face of mortal extinction, encompassing how changes to the DNA code can be both long-lasting and transgenerational, and the continuous nature of cellular and molecular information transmission. In tying these themes together, Immortal asks us to apply fresh scientific concepts to examine, for ourselves, the continuity of being in the face of mortality.

Advances in Insect Physiology Volume 60 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including The Steroid, Ecdysis Triggering Hormone, Juvenile Hormone Signaling Triad in Development and Reproduction, A Decade of Teasing Apart the Juvenile Hormone Receptor, Evolutionary Physiology of Peptidergic Signaling, Recent Advances in Neuroendocrine Regulation of Insect Excretory Systems, Recent Advances in Ecdysteroid Research in Insects, and Regulation and Mechanisms of Sleep in Drosophila.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Advances in Insect Physiology series

Ion Channels Part B, Volume 652 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including NMDAR, Pannexin, and CALHM, Making NaV1.4 and NaV1.7, TRPVs, Purification native nAChRs, GABAR Radu Aricescu, TRPV5/2, NaV1.5, KATP, TRPA1, TREK-1, SARS-CoV-2 3a ion channel, Ion channel conformational dynamics by encoded unnatural amino acid, Fluorescence lifetime measurement of absolute membrane potential, Fluorescent Toxins as Activity Sensors, FRET Analyses of Ion Channel Protein-Protein Interactions, Control of Ion Channel Gating with Photo-Switchable Tweezers, and Counting Subunits in Kv Channel Complexes.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Methods in Enzymology series

Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Methods in Enzymology series

Image Processing for Automated Diagnosis of Cardiac Diseases highlights current and emerging technologies for the automated diagnosis of cardiac diseases. It presents concepts and practical algorithms, including techniques for the automated diagnosis of organs in motion using image processing. This book is suitable for biomedical engineering researchers, engineers and scientists in research and development, and clinicians who want to learn more about and develop advanced concepts in image processing to overcome the challenges of automated diagnosis of heart disease.Includes advanced techniques to improve diagnostic methods for various cardiac diseasesUses methods to improve the existing diagnostic features of echocardiographic machinesDevelops new diagnostic features for echocardiographic machines

Risk Management in the Oil and Gas Industry: Offshore and Onshore Concepts and Case Studies delivers the concepts, strategies and good practices of offshore and onshore safety engineering that are applicable to petroleum engineering and immediately surrounding industries. Guided by the strategic risk management line, this reference organizes steps in order of importance and priority that should be given to the themes in the practical exercise of risk management activities, from the conceptual and design phase to operational and crisis management situations. Each chapter is packed with practical case studies, lessons learned, exercises, and review questions. The reference also touches on the newest techniques, including liquefied natural gas (cryogenics) operations and computer simulations that contemplate the influence of human behavior. Critical for both the new and experienced engineer, this book gives the best didactic tool to perform operations safely and effectively. Helps readers by presenting practical case studies and exercises that are included in every chapter Presents an understanding on how to approach and apply best practices specific to the oil and gas industry, both offshore and onshore Provides the knowledge needed to gain new techniques in computer simulation and human factors to apply to various sectors of the industry, including subsea and refineries

Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process. Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. Integrates experimental and computational methods for studying apoptosis in health and different diseasesIncludes strategies for identification of suitable therapeutic targetsDiscusses the design of treatments targeting key points in the apoptotic cascade

Well Integrity for Workovers and Recompletions delivers the concise steps and processes necessary to ensure that production wells minimize failure. After understanding the introductory background on well integrity and establishing the best baseline, the reference advances into various failure modes that can be expected. Rounding out with an explanation and tools concerning economic considerations, such as how to increase reserve potential and rate of return, the book gives oil and gas engineers and managers a vital solution to keeping their assets safe and effective for the long-term gain.

Handbook of Modern Coating Technologies: Fabrication Methods and Functional Properties reviews different fabrication methods and functional properties of modern coating technologies. The topics in this volume consist of nanocoatings by sol-gel processes for functionalization of polymer surfaces and textiles and mechanical fabrication methods of nanostructured surfaces such surface mechanical attrition treatment, polymer nanofabrications and its plasma processing, chemical vapor deposition of oxide materials at atmospheric pressure, conventional chemical vapor deposition process at atmospheric pressure, feasibility of atmospheric pressure, chemical vapor deposition process, Langmuir-Blodgett technique, flame pyrolysis, confined-plume chemical deposition, electrophoretic deposition, in vitro and in vivo particle coating for oral targeting and drug delivery, novel coatings to improve the performance of multilayer biopolymeric films for food packaging, corrosion protection by nanostructured coatings, tribological behavior of electroless coatings, effect of peening-based processes on tribological and mechanical behavior of bioimplant materials, improved efficiency of ceramic cutting tools in machining hardened steel with nanostructured multilayered coatings, incorporation of elastomeric secondary phase into epoxy matrix influences mechanical properties of epoxy coatings, enhancement of biocompatibility by coatings, porous hydroxyapatite-based coatings, and bionic colloidal crystal coatings.

The Cause of Pyloric Stenosis of Infancy chronicles the debate surrounding the cause of pyloric stenosis from its earliest discovery 300 years ago to the present. The Primary Hyperacidity Theory offers a credible explanation for all the classical signs and symptoms of pyloric stenosis as well a its associated features. In addition, this book comprehensively explores the medical and surgical treatment options as well as the general features used for diagnosis. An understanding of the true cause of pyloric stenosis will thus allow for treatment that is more individualized and sensitive to patients¿ needs.

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully.

Machine Learning and Data Science in the Oil and Gas Industry explains how machine learning can be specifically tailored to oil and gas use cases. Petroleum engineers will learn when to use machine learning, how it is already used in oil and gas operations, and how to manage the data stream moving forward. Practical in its approach, the book explains all aspects of a data science or machine learning project, including the managerial parts of it that are so often the cause for failure. Several real-life case studies round out the book with topics such as predictive maintenance, soft sensing, and forecasting. Viewed as a guide book, this manual will lead a practitioner through the journey of a data science project in the oil and gas industry circumventing the pitfalls and articulating the business value.

Retains the valuable organization and trusted coverage of previous market-leading editions Includes new coverage on biophysical applications and computer simulations Offers Mathematica files for student use and a secure solutions manual for qualified instructors Covers Bose-Einstein condensation in atomic gases, Thermodynamics of the early universe, Computer simulations: Monte Carlo and molecular dynamics, Correlation functions and scattering, Fluctuation-dissipation theorem and the dynamical structure factor, and much more

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Vitamins and Hormones seriesIncludes the latest information on Hormones and Synapse