Feedback Control for Personalized Medicine provides ideas on ongoing efforts and obstacles by members of the control engineering community in different biological and medical applications. In addition, the book presents key challenges, insights, tools and theoretical developments that arise from personalized medicine, along with medical concepts that are explained by engineers to help non-experts follow research topics. Several clinical trials have tried to find therapeutic approaches to achieve eradication or at least lifelong, therapy-free, host control of the infection. This has been performed integrating clinical observations, empirical knowledge and information from medical tests to treat patients. As this ¿trial and error approach is becoming more challenging and unfeasible by the steep increase in the number of different pieces of information and the complexity of large datasets, a systematic and tractable approach that integrates a variety of biological and medical research data into mathematical models and computational algorithms is crucial to harness knowledge and to develop new therapies towards personalized medicine.
Solar Energy Advancements in Agriculture and Food Production Systems aims to assist society and agricultural communities in different regions and scales to improve their productivity and sustainability. Solar energy, with its rapidly growing technologies and nascent market, has shown promise for integration into a variety of agricultural activities, providing an alternative, sustainable solution to current practices. To meet the future demands of modern sustainable agriculture, this book addresses the major existing problems by providing innovative, effective, and sustainable solutions using environment-friendly, advanced, energy-efficient, and cost-optimized solar energy technologies. This comprehensive book is intended to serve as a practical guide for scientists, engineers, policymakers, and stakeholders involved in agriculture and related primary industries, as well as sustainable energy development, and climate change mitigation projects. By including globally implemented solar-based agriculture projects in each chapter and highlighting the key associated challenges and benefits, it aims to bridge the knowledge gap between the market/real-world applications and research in the field.
Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Includes the latest information on Pseudokinases
Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Translational and Clinical Outcomes, Volume Three provides comprehensive information about ongoing research and clinical data on liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This updated volume discusses topics such as clinical and safety assessment of HCC patients, liver transplantation as a therapeutic option, immunotherapy interventions, and image-based surveillance. In addition, it discusses immunohistology of HCC-enabled precision medicine and artificial intelligence for hepatocellular carcinomas. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.
Next Generation Nanochitosan: Applications in Animal Husbandry, Aquaculture and Food Conservation provides comprehensive and state-of-the-art-information on the application of nanochitosan for improving products, especially for the evaluation of biological active molecules, disease therapeutics, transport vehicle for DNA, targeted drug delivery, gene therapy, development of smart and high performance of fish, preservation of foods, tissue engineering, and improving the taste of aquatic and animal feeds as fish growth promoter. this book will be especially useful for industrial fisheries who deal with wild capture fishing and aquafarming and scientists and engineers working on post-capture processing stages. Details on the application of nanochitosan as an effective delivery of vaccines, hormones, vitamins, nutrients and antioxidants, biological active constituents and their wider application for the protection and management of farm animals and fishes against disease-causing pathogens are provided.
Implementation of Smart Healthcare Systems using AI, IoT, and Blockchain provides imperative research on the development of data fusion and analytics for healthcare and their implementation into current issues in a real-time environment. While highlighting IoT, bio-inspired computing, big data, and evolutionary programming, the book explores various concepts and theories of data fusion, IoT, and Big Data Analytics. It also investigates the challenges and methodologies required to integrate data from multiple heterogeneous sources, analytical platforms in healthcare sectors. This book is unique in the way that it provides useful insights into the implementation of a smart and intelligent healthcare system in a post-Covid-19 world using enabling technologies like Artificial Intelligence, Internet of Things, and blockchain in providing transparent, faster, secure and privacy preserved healthcare ecosystem for the masses.
Single-Port Robotic Surgery in Urology: The New Beginning After the Advent of Dedicated Platforms describes the novel field of robotic single-port urologic surgery. Recent advances in surgical robotics combined with the pursuit to reduce the invasiveness of laparoscopic surgery have led to the development of novel robotic platforms specifically designed for single-port surgery. This reference summarizes the state-of-the-art of robotic single-port urologic surgery. Coverage takes a three-part approach, providing a description of the technological evolution which led to the advent of novel platforms specifically designed for single-port surgery, describing the urological procedures that can be performed, and outcomes and potential drawbacks.
Cancer: How Lifestyles May Impact Disease Development, Progression, and Treatment explores different processes that influence the efficacy of treatments and what lifestyle and behavioral modification options are available to patients to improve therapy responses, with a focus on addressing their strengths and weaknesses. The book discusses mechanisms by which particular lifestyles may affect cancer processes, including various aspects of immune functioning, inflammatory and energy-related processes, reactive oxygen species, hormonal and neurotransmitter mechanisms, the role of neurotrophins, and microbial effects. Considerable attention is devoted to the impact of psychosocial processes that indirectly affect disease occurrence, and to behavioral change methods.
In day-to-day practice, behavior analysts face many complex challenges that require both an accurate interpretation of ethical guidelines and a fair amount of independent judgment. Back to Basics: Ethics for Behavior Analysts guides readers on how to prevent conflicts and develop comfort where there is discomfort, while it also effectively and ethically disseminates information about the science of behavior analysis. The book includes both student and instructor resources, along with supplemental readings, podcast episodes, scenarios, essay prompts, and instructor quiz questions, making it a valuable resource for early career and seasoned analysts alike. Informed by the authors' decades of practice, this book provides a guide on how to successfully navigate ethical dilemmas using real-life scenarios.
Immunopathology, Diagnosis and Treatment of HPV induced Malignancies focuses on the human papilloma virus infection and associated cancers. In ten chapters, the book explains the deep knowledge about molecular mechanism in HPV pathogenesis and recent advanced tools applied in the field of HPV induced cancer and cures. In a nutshell, the book gives new insights and the associated challenges involved in the identification of promising drug and vaccine targets, current diagnostic tools, and advancements in current therapies against HPV induced cancers and other malignancies.
Sustainable Horticulture: Microbial Inoculants and Stress Interaction gives insights into the applications and formulations of microbial inoculants. In recent years, the optimum yields of horticultural plants largely influenced by rising global temperature, biotic stress (attack of pathogens) and abiotic stresses has created extra pressure for the horticulturalist to meet the need of optimum yield production for the burgeoning global population. However, the challenges of biotic and abiotic stress factors mitigated by traditional physical or chemicals methods include high application cost and adverse impact on quality limit the frequent use, hence the solutions in this book create new avenues for progress. This book covers those challenges and how microbial based bio inoculants are broadly used in horticulture to mitigate the challenges of biotic and abiotic stresses. It provides an important contribution on how to apply efficient beneficial microbes (microbial inoculants) for a sustainable society.
Cell Movement in Health and Disease brings the several scientific domains related to the phenomena together, establishing a consistent foundation for researchers in this exciting field. The content is presented in four main section. The first explores the foundations of Cell Movement, including overviews of cellular structure, signaling, physiology, motion-related proteins, and the interface with the cellular membrane. The second part covers the biological aspects of cellular movement, starting with chemical and mechanical sensing, describing the types of cell movement, mechanics at cell level, cell physiology, collective behavior, and the connections with the extracellular matrix. The following chapters provide an overview of the molecular machinery involved and cell-type specific movement. The third part of the book is dedicated to the translational aspects of cell movement, highlighting the key conditions associated with cell movement dysfunction, like cell invasion in cancer, wound healing, developmental issues, neurological dysfunctions, and immune response. The final part of the book covers key methods and modeling tools for cell movement research, including predictive mathematical models, in vitro and in vivo methods, biophysical and bioinformatics tools. Cell Movement in Health and Disease is the ideal reference for scientists from different backgrounds converging to expand the understanding of this key cellular process. Cellular and molecular biologists will gain a better understanding of the physical principals operating at cellular level while biophysicist and biomedical engineers will benefit from the solid biology foundation provided by the book.
Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review on Neurobiology serial Updated release includes the latest information on Tremors
Profiles of Drug Substances, Excipients, and Related Methodology, Volume 47 covers all aspects of drug development and formulation of drugs, meeting the information needs of the drug development community that are essential to all phases of pharmaceutical development. This updated release includes comprehensive profiles of five drug compounds: Vinpocetine; Loratadine; Ticagrelor; Lodenafil; Danazol. The volume also contains a chapter reviewing "Application of Chemometrics using direct Spectroscopic methods as a QC tool in Pharmaceutical Industry and their Validation.¿
Genetics and the Behavior of Domestic Animals, Third Edition offers the latest and most valuable information on animal science and behavioral genetics, carrying on the book¿s legacy since its original publication in 1998. This book synthesizes research from behavioral genetics and animal and veterinary science, bridging the gap between these fields. The objective is to show that principles of behavioral genetics have practical applications to agricultural and companion animals. The continuing domestication of animals is a complex process whose myriad impacts on animal behavior are commonly under-appreciated. Genetic factors play a significant role in both species-specific behaviors and behavioral differences exhibited by individuals in the same species. Leading authorities explore the impact of increased intensities of selection on domestic animal behavior. Rodents, cattle, pigs, sheep, horses, herding and guard dogs, and poultry are all included in these discussions of genetics and behavior, making this book useful to veterinarians, livestock producers, laboratory animal researchers and technicians, animal trainers and breeders, and any researcher interested in animal behavior. Genetics and the Behavior of Domestic Animals, Third Edition is the most valuable resource for researchers and practitioners in animal and veterinary science, animal behavior, genetics, ethology, and similar fields. Advanced undergraduate and graduate students in these disciplines will also benefit from the global expertise featured in this newest edition.
Complementarity of Variable Renewable Energy Sources consolidates current developments on the subject, addressing all technical advances, presenting new mapping results, and bringing new insights for the continuation of research and implementation on this fascinating topic. By answering questions such as How can complementarity be used in the operation of large interconnected systems?, What is the real applicability potential of energetic complementarity?, and How will it impact energy generation systems?, this title is useful for all researchers, academic and students investigating the topic of renewable energy complementarity in systems. In just over a decade, the subject of 'energy complementarity' has experienced a growing presence and understanding by researchers and managers of energy resources looking to enhance energy systems. Early research proposed methods to quantify complementarity, the effects of complementarity on performance of hybrid systems, and how to identify and map complementarity between solar energy, wind energy and hydroelectric energy systems.
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more.
Fractional Order Systems and Applications in Engineering presents the use of fractional calculus (calculus of non-integer order) in the description and modelling of systems and in a range of control design and practical applications. The book covers the fundamentals of fractional calculus together with some analytical and numerical techniques, and provides MATLAB® codes for the simulation of fractional-order control (FOC) systems. The use of fractional calculus can improve and generalize well-established control methods and strategies. Many different FOC schemes are presented for control and dynamic systems problems. These extend to the challenging control engineering design problems of robust and nonlinear control. Practical material relating to a wide variety of applications including, among others, mechatronics, civil engineering, irrigation and water management, and biological systems is also provided. All the control schemes and applications are presented with either system simulation results or real experimental results, or both. Fractional Order Systems and Applications in Engineering introduces readers to the essentials of FOC and imbues them with a basic understanding of FOC concepts and methods. With this knowledge readers can extend their use of FOC in other industrial system applications, thereby expanding their range of disciplines by exploiting this versatile new set of control techniques.
Thermofluids: From Nature to Engineering presents the fundamentals of thermofluids in an accessible and student-friendly way. Author David Ting applies his 23 years of teaching to this practical reference which works to clarify phenomena, concepts and processes via nature-inspired examples, giving the readers a well-rounded understanding of the topic. It introduces the fundamentals of thermodynamics, heat transfer and fluid mechanics which underpin most engineering systems, providing the reader with a solid basis to transfer and apply to other engineering disciplines. With a strong focus on ecology and sustainability, this book will benefit students in various engineering disciplines including thermal energy, mechanical and chemical, and will also appeal to those coming to the topic from another discipline.
Electric Motor Drives and Its Applications with Simulation Practices provides comprehensive coverage of the concepts of electric motor drives and their applications, along with their simulation using MATLAB and other software tools. The book helps engineers and students improve their software skills by learning to simulate various electric drives and applications and assists with new ideas in the simulation of electrical, electronics and instrumentations systems. Covering power electronic converter fed drives and simulation model building using all possible software as well as the operation and relevant applications discussed, the book provides a number of examples and step-by-step procedures for successful implementation. Intended for engineers, students and research scholars in industry who are working in the field of power electronics and drives, this book provides a brief introduction to simulation software under different environments. Provides an in-depth analysis of Electric motors and drives, specifically focused on practical approaches Includes simulations of electric drives using best proven software tools like MATLAB and PSIM Details step-by-step approaches for creating and applying simulation of electric drives
Application of Machine Learning in Smart Agriculture is the first book to present a multidisciplinary look at how technology can not only improve agricultural output, but the economic efficiency of that output as well. Through a global lens, the book approaches the subject from a technical perspective, providing important knowledge and insights for effective and efficient implementation and utilization of machine learning. As artificial intelligence techniques are being used to increase yield through optimal planting, fertilizing, irrigation, and harvesting, these are only part of the complex picture which must also take into account the economic investment and its optimized return. The performance of machine learning models improves over time as the various mathematical and statistical models are proven. Presented in three parts, Application of Machine Learning in Smart Agriculture looks at the fundamentals of smart agriculture; the economics of the technology in the agricultural marketplace; and a diverse representation of the tools and techniques currently available, and in development. This book is an important resource for advanced level students and professionals working with artificial intelligence, internet of things, technology and agricultural economics. Addresses the technology of smart agriculture from a technical perspective Reveals opportunities for technology to improve and enhance not only yield and quality, but the economic value of a food crop Discusses physical instruments, simulations, sensors, and markets for machine learning in agriculture
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