Böcker utgivna av Elsevier Science & Technology

Application of Natural Products in SARS-CoV-2 examines the potential for natural products to treat COVID-19, bringing together the most recent research. SARS-CoV-2 is a novel disease H54 that is still being researched despite being globally prevalent. There are still few proven treatments, so repurposing existing drugs and treatments is essential. While there have been many articles published on the subject, this book is the first to bring together data and research on the topic. It includes information about molecular mechanism, dosage and safety profiles, and an essential resource for all scientists and researchers working to combat SARS-CoV-2.

Energy storage plays an important role in supporting power-hungry devices and achieving stable power supply by optimally balancing supply and demand with ever-increasing requirement for computing power and the intermittent nature of renewable resources. Emerging Trends in Energy Storage Systems and Industrial Applications focuses on emerging trends in energy storage systems, applicable to various types of applications including heat and power generation, electrical and hybrid transportation. With performance limitations in current energy storage devices, such as limited energy density, power density, and cycle life, major challenges in the complex and dynamic environments of energy storage applications are examined in this reference. High-performance components, proper system configuration, effective modelling and control are keys to achieving seamlessly integrated and functional energy storage systems are also addressed, in order to provide guidance to achieving more reliable and efficient systems. Outcomes from this book serve as a resource for industrialists, academia and researchers working in the domain of advance energy storage technologies and their applications, giving them an overview of energy storage options, availability and technological trends enabling them to make longer-term, safe storage system decisions.

Viruses: From Understanding to Investigation, Second Edition presents the definitions and unique characteristics of viruses. The book includes major topics such as virus lifecycle, structure, taxonomy, evolution, history, host-virus interactions, and methods to study. In addition, the book assesses the connections between the aforementioned topics and provides an integrated approach and in-depth understanding of how viruses work. The new edition also provides an expanded methods chapter containing new information on deep sequencing for in virus identification, mathematical formulas to calculate titers and a description of quantitiative PCR for enumerating viruses. The vaccine chapter has been updated to include vaccine efficacy, mRNA vaccines and SARS-CoV-2 vaccine development. The viral pathogenesis chapter has been expanded to include mechanisms of virally induced cancers. Viral taxonomy sections have been updated and chapters revised to accommodate new virus family designations. New chapters include nucleocytoplasmic viruses (very large DNA viruses), replication of viroids and COVID-19/SARS-CoV-2.

RNA Methodologies: A Laboratory Guide for Isolation and Characterization, Sixth Edition provides the most up-to-date ribonucleic acid lab techniques for seasoned scientists and graduate students alike. This edition features new material on RNA sequencing, RNA in Situ Hybridization, non-coding RNAs, computational RNA biology, transcriptomes and bioinformatics, along with the latest advances in methods and protocols across the field of RNA investigation. As a leader in the field, Dr. Farrell provides a wealth of knowledge on the topic of RNA biology while also giving readers helpful hints and troubleshooting techniques from his own personal experience in this subject area. This book presents the essential knowledge and techniques to use when working with RNA for the experienced practitioner, while also aiding the beginner in fully understanding this important branch of molecular biology.

Data Mining: Concepts and Techniques, Fourth Edition introduces concepts, principles, and methods for mining patterns, knowledge, and models from various kinds of data for diverse applications. Specifically, it delves into the processes for uncovering patterns and knowledge from massive collections of data, known as knowledge discovery from data, or KDD. It focuses on the feasibility, usefulness, effectiveness, and scalability of data mining techniques for large data sets. After an introduction to the concept of data mining, the authors explain the methods for preprocessing, characterizing, and warehousing data. They then partition the data mining methods into several major tasks, introducing concepts and methods for mining frequent patterns, associations, and correlations for large data sets; data classificcation and model construction; cluster analysis; and outlier detection. Concepts and methods for deep learning are systematically introduced as one chapter. Finally, the book covers the trends, applications, and research frontiers in data mining.

Introduction to Materials Science and Engineering: A Design-Led Approach is ideal for a first course in materials for mechanical, civil, biomedical, aerospace and other engineering disciplines. The authors¿ systematic method includes first analyzing and selecting properties to match materials to design through the use of real-world case studies and then examining the science behind the material properties to better engage students whose jobs will be centered on design or applied industrial research. As with Ashby¿s other leading texts, the book emphasizes visual communication through material property charts and numerous schematics better illustrate the origins of properties, their manipulation and fundamental limits.

Food Quality Analysis: Applications of Analytical Methods Coupled With Artificial Intelligence provides different spectroscopic techniques and their application to food quality analysis, with the unique approach of adding multivariate analysis as well as artificial intelligence applications. It also brings chromatographic methods for the analysis of a wide range of food items including wheat flours, oils and fats. Written by a team of interdisciplinary experts, this is a valuable resource for researchers and personnel involved in food industries.

"Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on the research methodology for substance misuse and addiction intended for researchers and consumers of research information at all levels. The book is divided into three major parts: Research Methodology for Clinical Trials, Animal Research, and Retrospective Studies; Mechanisms of Drug Misuse and Addiction; and Investigative Therapeutics: Designing and Measuring Outcomes. It serves as a source that addresses all aspects of research design, methods, and analysis within the context of the field of opioids, alchohol, and other substances. The book discusses in detail the research methods used in designing prevention, screening, pharmacological management, and health services needed for substance misuse and addiction of all major illicit and prescribed drugs, foods, alcohol, and tobacco products. Research design and useful tips are provided for researchers and consumers of the literature, describing various biological methods, specialists, and analytical methods. The background is set up on the development of the discipline in question, its key features and applications, how the methods compare to other methods/analyses, and their advantages and limitations."--Back cover.

The Veterinary Psychiatry of Cats introduces veterinary behavioral medicine and veterinary psychiatry using the domestic cat as its model. This book combines the most up-to-date understanding of biology of this beloved, revered and often maligned species with learnings from the fields of normal and abnormal psychology. Written by a leading expert in feline behavior, this book begins by assessing "normal? factors of feline behavior, from neuroanatomy, neuroendocrinology, cognitive and social abilities. Delving into psychiatry, it then discusses mental health disorders, hindered development, and trauma. Psychopharmacology, including medications and supplements, are also explained. The Veterinary Psychiatry of Cats finishes with a comprehensive view of feline welfare management, how to treat cats humanely and how to house them responsibly given their behaviors. This is an ideal resource for feline behavioral specialists, veterinarians and domestic animal researchers and practitioners, including veterinary technicians, students and even feline owners.

Nanotechnological Applications in Virology explores the use of nanoparticles-based technologies to fight against viruses, also discussing the use of nanoparticles in the preparation of nano masks and as sanitizing agents. The role of nanotechnology against HIV, Hepatitis, Influenza, Herpes, Ebola and Zika using rapid detection and diagnostic techniques is included, as is a brief description of SARS, MERS, the novel Coronavirus, and recent advancements in its treatment process. Other sections cover the formulation of novel nano-vaccines for the treatment and control of viral infections like HIV, Hepatitis and COVID-19. Included toxicological studies of nanoparticles provide readers with a brief overview on global scenarios regarding viral infections. Nanotechnology is the present age technology, with wide usage in different areas of medical science, including drug delivery, gene therapy, antimicrobials, biosensors and bio-labelling. Nanoparticles play a competent role as an anti-infection agent and thus act as efficient antiviral agents.

Development and Commercialization of Biopesticides: Costs and Benefits provides a uniquely comprehensive view of the commercial production of biopesticides, from research to application, featuring case studies in various developed and developing countries of the world. The book offers guidance for future strategies to researchers, along with considerations for the industry¿s economic concerns, i.e., costs and benefits compared to conventional pesticides, future perspectives for application strategies, bioavailability and environmental safety, and impacts on intellectual property issues during commercialization. Finally, the book covers why the development of this industry must be strategic, comprehensive and forward-looking in order to be an accepted, safe and sustainable. There is no doubt that biopesticides are now in large-scale use, and a variety of novel techniques have been used to improve or modify existing biopesticides, which will further accelerate their development.

In the recent past, beneficial microorganisms have been sustainably used in agriculture as a safe, economic, and effective alternative to chemical fertilizers or pesticides. These beneficial microbes, including bacteria, actinomycetes, and yeast, were efficiently applied in soil, seeds, fruits, or plants as inoculants, to achieve the optimum agricultural yield. An efficient delivery method or enhanced shelf life of microbial inoculants in the soil or seed is still a matter of concern. The response of local genetic or ecological factors, after microbial applications, are also unknown and less studied. Therefore, Microbial Inoculants: Recent Progress and Applications fulfills the need to explore and learn about an efficient delivery mechanism, selection of microbial strain as inoculants, and related technological advances, for the efficient and productive use of microbial inoculants. Moreover, factors like methods of formulation, interaction between host plant and microbe, impact of inoculation on the metabolomics of plants, the effect of microbial inoculants on soil dynamics, proteomics approach of plant-microbe interaction, as well as the registration and regulation process of bio inoculants for commercial production are described in 16 chapters by the leading academicians and researchers from different parts of the world.

Advances in Parasitology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Parasitology serials pdated release includes the latest information on Accomplishment of Malaria Elimination in the People''s Republic of China

Methods in Cancer Stem Cell Biology: Part B, Volume 171 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of Methods in Cancer Stem Cell Biology

Advanced Fiber Access Networks takes a holistic view of broadband access networks-from architecture to network technologies and network economies. The book reviews pain points and challenges that broadband service providers face (such as network construction, fiber cable efficiency, transmission challenges, network scalability, etc.) and how these challenges are tackled by new fiber access transmission technologies, protocols and architecture innovations. Chapters cover fiber-to-the-home (FTTH) applications as well as fiber backhauls in other access networks such as 5G wireless and hybrid-fiber-coax (HFC) networks. In addition, it covers the network economy, challenges in fiber network construction and deployment, and more. Finally, the book examines scaling issues and bottlenecks in an end-to-end broadband network, from Internet backbones to inside customer homes, something rarely covered in books. Provides the latest information on end-to-end broadband access networks, from architecture to network technologies and network economies

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

Statistical Modeling in Machine Learning: Concepts and Applications presents the basic concepts and roles of statistics, exploratory data analysis and machine learning. The various aspects of Machine Learning are discussed along with basics of statistics. Concepts are presented with simple examples and graphical representation for better understanding of techniques. This book takes a holistic approach ¿ putting key concepts together with an in-depth treatise on multi-disciplinary applications of machine learning. New case studies and research problem statements are discussed, which will help researchers in their application areas based on the concepts of statistics and machine learning. Statistical Modeling in Machine Learning: Concepts and Applications will help statisticians, machine learning practitioners and programmers solving various tasks such as classification, regression, clustering, forecasting, recommending and more.

Postharvest Management of Fresh Produce: Recent Advances critically addresses the latest issues, challenges, and technological advancements in postharvest management of fresh commodities, especially fruits, nuts, and vegetables. The book covers the intriguing correlation of preharvest treatments, maturity indices and postharvest operations that significantly affect the postharvest quality of fresh produce. Further topics include packaging, logistics and storage technologies, the role of microbial communities, and 'omics' strategies in postharvest disease management. Special attention is given to the latest trends of nanotechnology, internet of things (IoTs), and blockchain technologies in food supply chain management of perishable products. The book is a great resource for young and experienced professionals in academia, industry, and UG/PG students to explore a diversified range of topics in postharvest strategies relevant to food processing, food technologies, agro-processing and quality control.

Preceded by: Health information exchange / edited by Brian E. Dixon. [2016].

Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis has been a key area of biological inquiry for decades. The next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution. Transcriptome analysis has evolved from the detection of single RNA molecules to large-scale gene expression profiling and genome annotation initiatives. Written by a team of global experts, key topics in Transcriptome Profiling include transcriptome characterization, expression analysis of transcripts, transcriptome and gene regulation, transcriptome profiling and human health, medicinal plants transcriptomics, transcriptomics and genetic engineering, transcriptomics in agriculture, and phylotranscriptomics.

Connectome Analysis: Characterization, Methods, and Analysis is a comprehensive companion for the analysis of brain networks, or connectomes. The book provides sources of constituent structural and functional MRI signals, network construction and practices for analysis, cutting-edge methods that address the latest challenges in neuroscience, and the fundamentals of network theory in the context of giving practical methods for building connectomes for analysis. Emphasis is placed on quality control of the individual analysis steps. Subsequent chapters discuss networks in neuroscience in clinical and general populations, including how findings are related to underlying neurophysiology and neuropsychology. This book is aimed at students and early-career researchers in brain connectomics and neuroimaging who have a background in computer science, mathematics and physics, as well as more broadly to neuroscientists and psychologists who want to start incorporating connectomics into their research.

The excessive use of antibiotics has given rise to an increase in microbial resistance, threatening our ability to treat infectious diseases. The growth in resistance to antimicrobials and antibiotics threatens to reverse almost a century of medical progress. urgent action plans to tackle the crisis of Antimicrobial Resistance (AMR) and multi-resistant bacteria are needed. It is a major research task to find effective ways to reduce the release and degradation of antibiotics and ARBs to the environment. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources addresses various issues related the generations and degradations, eliminations of antibiotics and antibiotics resistance bacteria. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources contains both practical and theoretical latest and broad aspects of antibiotics and antibiotics resistance bacteria management through the various recent methods. Various factors which are responsible for the efficient degradations are highlighted in the Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources as separate chapters. Socioeconomic and policies on the ARBs are also discussed.

Deep neural networks (DNNs) with their dense and complex algorithms provide real possibilities for Artificial General Intelligence (AGI). Meta-learning with DNNs brings AGI much closer: artificial agents solving intelligent tasks that human beings can achieve, even transcending what they can achieve. Meta-Learning: Theory, Algorithms and Applications shows how meta-learning in combination with DNNs advances towards AGI. Meta-Learning: Theory, Algorithms and Applications explains the fundamentals of meta-learning by providing answers to these questions: What is meta-learning?; why do we need meta-learning?; how are self-improved meta-learning mechanisms heading for AGI ?; how can we use meta-learning in our approach to specific scenarios? The book presents the background of seven mainstream paradigms: meta-learning, few-shot learning, deep learning, transfer learning, machine learning, probabilistic modeling, and Bayesian inference. It then explains important state-of-the-art mechanisms and their variants for meta-learning, including memory-augmented neural networks, meta-networks, convolutional Siamese neural networks, matching networks, prototypical networks, relation networks, LSTM meta-learning, model-agnostic meta-learning, and the Reptile algorithm. The book takes a deep dive into nearly 200 state-of-the-art meta-learning algorithms from top tier conferences (e.g. NeurIPS, ICML, CVPR, ACL, ICLR, KDD). It systematically investigates 39 categories of tasks from 11 real-world application fields: Computer Vision, Natural Language Processing, Meta-Reinforcement Learning, Healthcare, Finance and Economy, Construction Materials, Graphic Neural Networks, Program Synthesis, Smart City, Recommended Systems, and Climate Science. Each application field concludes by looking at future trends or by giving a summary of available resources. Meta-Learning: Theory, Algorithms and Applications is a great resource to understand the principles of meta-learning and to learn state-of-the-art meta-learning algorithms, giving the student, researcher and industry professional the ability to apply meta-learning for various novel applications.

Biomedical Defense Principles to Counter DNA Deep Hacking presents readers with a comprehensive look at the emerging threat of DNA hacking. Dr. Rocky Termanini goes in-depth to uncover the erupting technology being developed by a new generation of savvy bio-hackers who have skills and expertise in biomedical engineering and bioinformatics. The book covers the use of tools such as CRISPR for malicious purposes, which has led agencies such as the U.S. Office of the Director of National Intelligence to add gene editing to its annual list of threats posed by "weapons of mass destruction and proliferation." Readers will learn about the methods and possible effects of bio-hacking attacks, and, in turn the best methods of autonomic and cognitive defense strategies to detect, capture, analyze, and neutralize DNA bio-hacking attacks, including the versatile DNA symmetrical AI Cognitive Defense System (ACDS). DNA bio-hackers plan to destroy, distort and contaminate confidential, healthy DNA records and potentially create corrupted genes for erroneous diagnosis of illnesses, disease genesis and even wrong DNA fingerprinting for criminal forensics investigations.

Quinoa: Chemistry and Technology provides an overview of the chemistry, processing, and technology of quinoa grain and its components, covering the development of quinoa grain in different parts of the world for food production, including its structure, molecular and chemical composition, milling properties, processing characteristics, and food products. Increasing demand for plant-based, gluten-free foods that are nutritious, healthy, sustainable, and affordable has caused quinoa cultivation to expand to over 70 countries due to its attractive nutritional and food security properties. This practical resource is designed to support the development of quinoa in different sectors, such as the food industry.