Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. Provides information on the design and development of nanocarriers for targeting brain tumors Outlines the working principles of different nanocarriers for targeting brain tumors Includes case studies of different nanocarriers for targeting brain tumors
Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed. Highlights in silico approaches to drug design and discovery using computational tools and techniques Details ligand-based and structure-based drug design in a comprehensive and systematic approach Summarizes recent developments in computational drug design strategy as novel approaches of rational drug designing
Electrochemical Phenomena in the Cathode Impedance Spectrum of PEM Fuel Cells: Fundamentals, Modelling, and Applications establishes how the electrochemical and diffusion mechanisms of a polymer electrolyte membrane fuel cell (PEMFC) are related to electrochemical impedance spectroscopy (EIS) measurements using physics-based impedance models derived from fundamental electrode and diffusion theories. The contribution of the different phenomena occurring at the different layers comprising the cathode on the impedance response of the PEMFC is revealed through EIS-modelling analysis. The relation between EIS measurements and polarisation curves representing the performance of PEMFCs is established. Insight is gained into how the EIS response of the PEMFC changes at different operating conditions e.g. relative humidity, load demand, gas reactant stoichiometry and temperature using physics-based impedance models. The application of impedance models with EIS measurements carried out in the individual cells comprising a PEMFC stack is demonstrated, while recent modelling approaches and other impedance models reported in the literature to represent the EIS response of the PEMFC are also considered and discussed. Provides further understanding of ambiguities during the interpretation of the electrochemical impedance spectrum of the PEMFC. Includes impedance models written in MATLAB® for replication or application to other PEMFC-EIS measurements. Includes impedance spectra of the PEMFC at different operating conditions, electro/diffusion pathways for derivation of the impedance models and flowcharts for application of the impedance models with real-world measured EIS data.
Applications of Nanofluids in the Chemical and Biomedical Process Industry provides detailed knowledge about the mathematical, numerical and experimental methodologies of the application of nanofluids in heat transfer, mass transfer and biomedical processes. The book is divided into three main sections, with chapters detailing thermophysical and optical properties of nanofluids enhancement in heat exchangers and boiling operations, presenting a detailed overview of nanofluid application in CO2 absorption/regeneration and metal extraction/stripping operations, and finally providing an overview of the application of nanofluids in biomedical processes. The book includes recent advances, as well as challenges to nanofluid applications in industrial processes and will be useful for researchers and professionals working in industry or academia, as well as others interested in the applications of the nanofluids to industrial processes for design purposes. Includes numerical and experimental investigations of hybrid and mono nanoparticle based nanofluids Investigates the comparative performance of various nanofluids for CO2 absorption/regeneration and metal extraction/stripping operations Covers industrial operation challenges and scale-up challenges for nanofluid applications in the industrial process
Affine Arithmetic-Based Methods for Uncertain Power System Analysis presents the unique properties and representative applications of Affine Arithmetic in power systems analysis, particularly as they are deployed for reliability optimization. The work provides a comprehensive foundation in Affine Arithmetic necessary to understand the central computing paradigms that can be adopted for uncertain power flow and optimal power flow analyses. These paradigms are adapted and applied to case studies, which integrate benchmark test systems and full step-by-step procedure for implementation so that readers are able to replicate and modify. The work is presented with illustrative numerical examples and MATLAB computations.
Present-day interest in pyrochlore materials is immense. Academic and industrial researchers working with pyrochlore materials need a fundamental understanding of what pyrochlores are and their potential applications. Pyrochlore Ceramics: Properties, Processing, and Applications provides key knowledge and information needed on pyrochlore materials. With an emphasis on recent research developments, the contents review a broad spectrum of pyrochlore systems, focusing on their structures, their successful synthesis, multifaceted properties, and applications. The book brings all aspects together and presents recent research findings on pyrochlore materials. It will be the definitive text for all researchers who aim to venture into the eclectic world of pyrochlores. In addition, the book will be of interest to researchers who are already working on pyrochlore materials, providing them with novel information on the uncommon virtues of pyrochlore systems. All chapters presented in the book are at the cutting edge of research and have never been assembled in book form before. Any researcher working in related fields will gain not only a historical perspective but also a comprehensive overview of recent developments. The book will be a valuable reference resource for academic and industrial researchers working in ceramics and materials science, mechanical, electronics, and chemical engineering, as well as physical and chemical science. Provides an extensive review of novel pyrochlore material systems Compares different types of pyrochlore materials, including their structure, properties, and performance Describes potential applications
Algae Biotechnology: Integrated Algal Engineering for Bioenergy, Bioremediation, and Biomedical Applications covers key applications of algae for bioenergy and how to integrate the production of biofuels with environmental, nutraceutical and biomedical processes and products. The book emphasizes cost-effective biofuels production through integrated biorefinery, combining continuous processes and various algae as feedstock to produce biofuel, bioenergy and various high value biochemicals. Novel algal culturing technologies and bioprocess engineering techniques are provided for the optimization of operational approaches for commercial-scale production, as well as to reduce the overall costs. New and existing molecular methods for genetic and metabolic engineering of algae are also presented. Furthermore, methods for the optimization of existing biochemical pathways are explained, and new pathways are introduced, in order to maximize the potential for biofuels production and related nutraceutical and biomedical co-products. This book provides an ideal roadmap for bioenergy researchers and engineers who want to incorporate valuable nutraceutical and biomedical products and environmental practices into the production of biofuels. Addresses issues faced by the bioenergy sector and how to resolve them through the integration of algal biotechnology and engineering Provides a guide to the efficient and cost-effective production of bioenergy, while simultaneously mitigating pollution and producing valuable nutraceutical and biomedical biproducts Covers new and emerging approaches in integrated algal biotechnology Offers a roadmap to their application in the production of biofuels alongside nutraceutical, biomedical, and environmental processes and products
Machinery and Energy Systems for the Hydrogen Economy covers all major machinery and heat engine types, designs and requirements for the hydrogen economy, from production through storage, distribution and consumption. Topics such as hydrogen in pipeline transport, for energy storage, and as a power plant fuel are covered in detail. Hydrogen machinery applications, their selection criteria, economics, safety aspects and operational limitations in different sectors of the hydrogen economy are also discussed. Although the book covers the hydrogen economy as a whole, its primary focus is on machinery and heat engine design and implementation within various production, transport, storage and usage applications. An invaluable resource for industry, academia and government, this book provides engineers, scientists and technical leaders with the knowledge they need to design and build the infrastructure of a hydrogen economy. Updates the award-winning first edition in all aspects of sequence stratigraphy, from underlying theory to practical applications Includes broad coverage of topics, including sequence stratigraphic methodology, nomenclature, and classification, the role of modeling in sequence stratigraphy, the difference between modeling and methodology, and the issue of scale and stratigraphic resolution Presents the three-dimensional nature of stratigraphic architecture and the variability of stratigraphic sequences with the tectonic setting, depositional setting, and the climatic regime Illustrated with numerous high-quality diagrams, outcrop photographs and subsurface borehole and seismic data
Planetary Exploration Horizon 2061: A Long-Term Perspective for Planetary Exploration synthesizes all the material elaborated and discussed during three workshops devoted to the Horizon 2061 foresight exercise. Sections cover the science of planetary systems, space missions to solar system objects, technologies for exploration, and infrastructures and services to support the missions and to maximize their science return. The editors follow the path of the implementation of a planetary mission, from the needed support in terms of navigation and communication, through the handling of samples returned to Earth, to the development of more permanent infrastructures for scientific human outposts on the Moon and Mars. This book also includes a special chapter entirely devoted to contributions from students and early-career scientists: the ¿Horizon 2061 generation and a final chapter on important avenues for the actual implementation of the planetary missions coming out of our ¿Dreams for Horizon 2061: International cooperation, and the growing role and initiatives of private enterprise in planetary exploration.
Environmental Sustainability and Industries identifies and discusses critical areas related to environmentally conscious industrial development of products and services that may support more sustainable and equitable societies. This book addresses pollution prevention by referring to the use of processes, practices, and materials that reduce or eliminate the generation of pollutants at the source of production, more efficient use of raw materials, energy, water or other resources, or by conserving natural resources by maintaining clean production. It explains industrial energy efficiency as the most cost-effective use of energy in manufacturing processes, reducing its wastage as well as the total consumption of primary energy resources. Life cycle assessment is used as an analytical method to quantify environmental impacts, focusing on environmental considerations concerning process design and optimization, and including various sustainable manufacturing parameters in the context of industrial processes and proposes a classification of identified parameters to evaluate and optimize the manufacturing performances. The book also dives into industrial ecology, investigating how, where, and why environmental improvements can be made to develop a sustainable industry, meeting the needs of current generations without sacrificing the needs of the future ones. This book analyzes a company''s environmental, social, and economic performance and their interrelationships, emphasizing the importance of identifying and understanding causal relationships between alternative approaches to action and their impact on financial and nonfinancial performance. It concludes with a view on the future of sustainable industrial systems stressing change as a joint effort of scientists, governments, people in business, and academicians. Offers compiled information on the environmental sustainability for industry Provides principles and advanced trends and approaches for environmental sustainability for the industrial sector Discusses established and emerging technologies and processes for sustainable approaches for industry Presents the development in the use of the assessment models as a tool to support the research and applications of different sustainable technologies and processes
Ceramic Science and Engineering: Basics to Recent Advancements covers the fundamentals, classification and applications surrounding ceramic engineering. In addition, the book contains an extensive review of the current published literature on established ceramic materials. Other sections present an extensive review of up-to-date research on new innovative ceramic materials and reviews recently published articles, case studies and the latest research outputs. The book will be an essential reference resource for materials scientists, physicists, chemists and engineers, postgraduate students, early career researchers, and industrial researchers working in R&D in the development of ceramic materials. Ceramic engineering deals with the science and technology of creating objects from inorganic and non-metallic materials. It combines the principles of chemistry, physics and engineering. Fiber-optic devices, microprocessors and solar panels are just a few examples of ceramic engineering being applied in everyday life. Advanced ceramics such as alumina, aluminum nitride, zirconia, ZnO, silicon carbide, silicon nitride and titania-based materials, each of which have their own specific characteristics and offer an economic and high-performance alternative to more conventional materials such as glass, metals and plastics are also discussed.
Relationship Between Microbes and Environment for Sustainable Ecosystem Services, Volume Two: Microbial Mitigation of Waste for Sustainable Ecosystem Services promotes advances in sustainable solutions, value-added products, and fundamental research in microbes and the environment. Topics include advanced and recent discoveries in the use of microbes for sustainable development. Volume Two describes the successful application of microbes and their derivatives for waste management of potentially toxic and relatively novel compounds. This proposed book will be helpful to environmental scientists, experts and policymakers working in the field of microbe- based mitigation of environmental wastes. The book provides reference information ranging from the description of various microbial applications for the sustainability in different aspects of food, energy, environment industry and social development. Covers the latest developments, recent applications and future research avenues in microbial biotechnology for sustainable development Includes expressive tables and figures with concise information about sustainable ecosystem services Provides a wide variety of applications and modern practices of harnessing the potential of microbes in the environment
Biogenic Sustainable Nanotechnology: Trends and Progress focuses on the green synthesis of nanomaterials with various biological systems, emphasizing the mechanisms of nanomaterial synthesis, spectroscopic characterizations, and applications in a variety of industrial sectors. Interest in developing eco-friendly, green, cost-effective, and facile methods for nanomaterials synthesis is rapidly growing. Green synthesis methods focus on a greener environment, minimizing generated waste, and implementing sustainable processes. As discussed in this book, green nanostructured materials often include phytochemical agent extracts, such as carbohydrates, flavonoids, saponins, proteins, amino acids, chromone, steroids, phytol, and terpenoids. These phytochemicals from plant extracts play a crucial role in improving the reduction rate, size, and stabilization, by acting as good reducers, surfactants, structure directors, and capping agents. This book is an essential reference source for materials scientists, bioengineers, and environmental scientists. Outlines the major synthesis methods used to create environmentally-friendly bionanomaterials for biomedical applications Explores how environmentally-friendly bionanomaterials are used for a variety of industry sectors Assesses the major challenges of producing environmentally-friendly biogenic nanomaterials on an industrial scale
Oxygen Reduction Reaction: Fundamentals, Materials and Applications covers the design, synthesis and performance efficacies of the entire spectrum of oxygen reduction catalysts, extrapolating down to their applications in practical, alternative, renewable energy devices. Catalysts covered include heme inspired iron-based, heme inspired non-iron-based, non-heme-based, noble metal-based, non-noble metal-based and metal-free homogeneous and heterogeneous catalysts. The book contains critical analyses and opinions from experts around the world, making it of interest to scientists, engineers, industrialists, entrepreneurs and students. Discusses the fundamental aspects of oxygen reduction reactions Offers a comprehensive analysis of the choice and development of catalyst materials for oxygen reduction reaction Reviews emerging catalyst systems for oxygen reduction reaction Includes analyses of catalytic performance parameters to evaluate their efficacy in oxygen reduction reactions under varied operating conditions Covers the importance of oxygen reduction reaction catalysts and processes in real-life applications
Hybrid and Combined Processes for Air Pollution Control: Methodologies, Mechanisms and Effect of Key Parameters provides an exhaustive inventory of hybrid and combined processes in the field of air treatment. The book covers principles, the effect of key parameters, technologies and reactors of the processes and their implementation, from lab-scale to industrial scale, also identifying future trends. Sections discuss effects on the environment and living beings, identify novel techniques and innovations, and offer a thorough assessment of the strengths and weaknesses of each. In this well-structured book, chapters are linked to the type of treatment, with a significant part dealing with treatment by transfer processes: (absorption and absorption) and on destruction treatments, such as advanced oxidation processes. Helps readers select the most appropriate process for air pollution treatment and control Provides a comprehensive overview of process performance under real conditions, from lab to industrial scale Identifies future trends in industrial developments and innovation
Metal Oxides for Optoelectronics and Optics-based Medical Applications reviews recent advances in metal oxides and their mechanisms for optoelectronic, photoluminescent and medical applications. In addition, the book examines the integration of key chemistry concepts with nanoelectronics that can improve performance in a diverse range of applications. Sections place a strong emphasis on synthesis processes that can improve the metal oxides'' physical properties and the reflected surface chemical changes that can impact their performance in various devices like light-emitting diodes, luminescence materials, solar cells, etc. Finally, the book discusses the challenges associated with the handling and maintenance of metal oxides crystalline properties. This book will be suitable for academics and those working in R&D in industry looking to learn more about cheaper and more effective methods to produce metal oxides for use in the fields of electronics, photonics, biophotonics and engineering. Reviews the latest advances in the utilization of metal oxide materials in photonics, optoelectronics and optics-based medical applications Considers the most relevant synthesis strategies for the development of high-performing metal oxide-based devices Addresses a wide range of metal oxides including photonic crystals, fibers, metastructures, glasses, and more
Sustainable Alternatives for Aviation Fuels presents a technical and economic guide on the development of sustainable aviation fuels from renewable sources. With a focus on commercial viability and cost reduction, the book explores every aspect of the alternative aviation fuels supply chain, including commercially feasible and environmentally sound feedstock, production routes, the roles of catalysts in processing, conceptual process design, process economics, engine performance, future market trends and case studies. Readers are provided with the tools to make decisions at every stage that are supported by in-depth techno-economic analyses, lifecycle assessments, and considerations for development prospects within the context of sustainability. This book offers an excellent overview for readers involved in bioenergy and aviation. It is an invaluable resource for researchers and industry practitioners seeking to produce commercially viable, alternative aviation fuels. Presents the current sustainable alternative fuels for aviation, including commercially viable and environmentally sound feedstock and production routes Provides practical guidance on topics such as the role of catalysts in processing, conceptual process design and engine performance analysis Explores process economics, market trends and LCA analysis, in addition to a techno-economic analysis of biojet fuel and its sustainability
Advances in Metal Oxides and their Composites for Emerging Applications reviews key properties of metal-oxide based composites, including their structural, physicochemical, optical, electrical components and resulting performance in a wide range of diverse applications. Synthetic protocols used to create metal oxides with desirable morphologies, properties and performance for applications in solar energy harvesting, energy storage and environmental remediation are emphasized. Emerging technologies that address important global challenges such as energy shortage, the hazardous effects of non-renewable energy sources, unaffordable energy technologies, and the contaminants present in air and water are also covered. This book is an ideal resource for materials scientists and engineers working in academia and R&D. In addition, it''s appropriate for those who either need an introduction to potential research directions or for experienced researchers and practitioners looking for a key reference on the latest advances. Introduces the fundamental properties of metal oxide-based composites, paying special attention to physicochemical, optical, electrical and structural characteristics Provides an overview of the synthetic protocols used to design and tune the properties of metal oxide-based composites for key emerging applications Discusses metal oxide-based composites and their use in energy applications such as energy storage, energy harvesting and environmental remediation
Global Urban Heat Island Mitigation provides a comprehensive picture of global UHI micro-thermal interaction in different built environments. The book explains physical principles and how to moderate undesirable consequences of swift and haphazard urban development to create more sustainable and resilient cities. Sections provide extensive discussion on numerous UHI mitigation technologies and their effectiveness in cities around the globe. In addition, the book proposes novel UHI mitigation technologies and strategies while also assessing the effectiveness and suitability of UHI mitigation interventions in various climates and urban forms. Adopts a multidisciplinary approach, bridging theoretical and applied urban climatology with urban heat mitigation Compiles disparate urban climate research concepts and technologies into a coherent framework Includes contributions from leaders in fields from around the globe
Plasmonic Materials and Metastructures: Fundamentals, Current Status, and Perspectives reviews the current status and emerging trends in the development of conventional and alternative plasmonic materials. Sections cover fundamentals and emerging trends of plasmonic materials development, including synthesis strategies (chemical and physical) and optical characterization techniques. Next, the book addresses fundamentals, properties, remaining barriers for commercial translation, and the latest advances and opportunities for conventional noble metal plasmonic materials. Fundamentals and advances for alternative plasmonic materials are also reviewed, including two-dimensional hybrid materials composed of graphene, monolayer transition metal dichalcogenides, boron nitride, etc. In addition, other sections cover applications of plasmonic metastructures enabled by plasmonic materials with improved material properties and newly discovered functionalities. Applications reviewed include quantum plasmonics, topological plasmonics, chiral plasmonics, nanolasers, imaging (metalens), active, and integrated technologies.
Nano-Enabled Technologies for Water Remediation highlights several aspects of wastewater treatment using low-dimensional carbon-based materials. The book also focuses on advances in membrane-based separation, specifically on the pressure driven membrane process. In the case of membrane advances, the focus is exclusively on metal and metal oxide, mixed matrix membranes, GO, and CNT loaded membranes for targeted pollutant removal. Further, new and upcoming technologies of membrane preparation, via the electrospinning method, and advances in membrane distillation and wastewater remediation are discussed. In addition, the book includes coverage of recent advances occurring in sustainable technologies for wastewater remediation with bio-active nanomaterials, bio-inspired, and bio-templated nanomaterials which assist readers in gaining a new perspective for implementing nature-mimicked designs for water treatment and conservation. Covers fundamental theories for complex technologies so that the readers do not need to sift through large quantities of available literature Provides information on major nano-enabled technologies for wastewater treatment, such as composite membranes, electrospun nanofibrous membranes, visible-light catalysts, multi-functional adsorbents, hydrogels, bio-active materials, bio-inspired materials, and more Assesses the major challenges to integrating nanotechnology solutions to water remediation processes in a scalable and cost-efficient manner
Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis summarizes the most significant progress in the field of chiral phosphine ligand chemistry and a broad range of earth-abundant transition metal/chiral phosphine ligand-catalyzed enantioselective transformations. The book provides an authoritative and in-depth understanding of important topics about asymmetric catalysis based on earth-abundant transition metals/chiral phosphine ligands, making it ideal for organic chemistry researchers working in the field of asymmetric catalysis, synthetic methodologies and total synthesis.The development of new chiral phosphine ligands to achieve precise stereo control in many earth-abundant transition metal-catalyzed reactions is a very important field in organic synthesis, materials science and medicinal chemistry. The asymmetric synthesis promoted by transition metal/chiral phosphine ligands provides one of the most ideal ways to produce valuable optically active chemicals.
Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale
In this issue of Critical Care Clinics, guest editors Drs. Robert M. Kliegman and Brett J. Bordini bring their considerable expertise to the topic of Undiagnosed and Rare Diseases in Critical Care. Top experts in the field cover key topics such as critical genetic arrhythmia disorders, uncommon causes of rhabdomyolysis,  status epilepsy syndromes, autoimmune encephalitis, rapid-onset paralysis and weakness, and more. Contains 17 relevant, practice-oriented topics including understanding cognitive diagnostic errors in the ICU; rapid WES/WGS in the ICU; diagnostic time-outs to improve diagnosis; when "sepsis” is not sepsis: MAS, HLH, malignancies and other sepsis mimics; all that wheezes is not asthma or bronchiolitis; and more.  Provides in-depth clinical reviews on undiagnosed and rare diseases in critical care, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 
In this issue of Pediatric Clinics of North America, guest editors Drs. Huma Quraishi and Michael Chee bring their considerable expertise to the topic of Pediatric Otolaryngology. National health statistics indicate that disorders of the ear, nose, and throat are among the primary reasons children visit a physician, with ear infections ranking as the number one reason. This issue provides a comprehensive overview of otolaryngologic issues affecting children, providing the clinical information pediatricians need to make prompt diagnoses and facilitate positive patient outcomes. Contains 14 relevant, practice-oriented topics including otitis media and myringotomy tubes; congenital sensorineural hearing loss; tethered oral tissue/ankyloglossia/tongue and lip tie; adenotonsillectomy; pediatric obstructive sleep apnea syndrome; recurrent croup; and more.  Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 
Covering the entire spectrum of this fast-changing field, Diagnostic Imaging:Musculoskeletal Non-Traumatic Disease, third edition, is an invaluable resource formusculoskeletal radiologists, general radiologists, and trainees-anyone whorequires an easily accessible, highly visual reference in this complex area ofimaging. Drs. Kirkland W. Davis, Donna G. Blankenbaker, Stephanie A. Bernard, andtheir team of highly regarded experts provide up-to-date information on recentadvances in technology and the understanding of musculoskeletal diseasesand disorders to help you make informed decisions at the point of care. The textis lavishly illustrated, delineated, and referenced, making it a useful learning tool aswell as a handy reference for daily practice. Guides readers through the complexities of the full range of non-traumatic musculoskeletal disorders, including arthritis, collagen vascular diseases, bone tumors, soft tissue tumors, infections, systemic diseases, developmental and congenital abnormalities, and metabolic diseases Contains multiple new chapters on topics such as musculoskeletal genetics, neurinomas, and rapidly progressive osteoarthritis, among others, as well as updates throughout on reclassified lesions, tumors, and neoplasms; musculoskeletal infection details, including image-guided aspirations and biopsies for infections; and evolving medical and surgical treatments for many musculoskeletal conditions Reflects recent changes in the World Health Organization''s classification of tumors and tumor-like conditions regarding terminology and diagnostic criteria Covers evolving imaging techniques such as ultrasound in non-traumatic disease imaging, contrast-enhanced ultrasound use in tumor biopsies, enhanced MR of musculoskeletal tumors, and diffusion-weighted MR, and PET/CT and PET/MR use for rapidly progressive osteoarthritis Provides up-to-date discussions of enhancements in bone and soft tissue tumor pathology and imaging of orthopedic implants and related hardware Features more than 3,750 annotated images (with an additional 2,100+ digital-only examples), including radiologic images, full-color medical illustrations, clinical and histologic photographs, and gross pathology images Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care
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