Offering focused, practical, and up-to-date content on immunotherapies used to treat a wide variety of cancer types, Clinical Immuno-Oncology covers the basic cellular and molecular mechanisms involved in cancer initiation and progression. The text reviews the development of tumor specific antigens and the challenges of developing cancer immunotherapies. Every effort is made to relate the fundamental aspects of host immunity to the efficacy of current immunotherapies and how they work in conjunction with the immune system to combat cancer. This foundational resource explains the basics of cancer immunotherapy, discusses best practices, and provides recommendations from experienced clinicians in the field. Dr. John E. Niederhuber and a team of expert contributing authors provide clinically focused information essential for integrating these new therapies into practice-making this an ideal resource for fellows, practitioners, and other cancer team members in medical oncology, radiation oncology, cancer surgery, immunology, and cancer research. Offers balanced and synthesized content on clinical science, clinical and translational research, and evidence-based practice for cutting-edge immunotherapies. Discusses clinical applications of immunotherapies in common types of cancer including melanoma, breast cancer, pancreatic cancer, colon and rectum cancer, prostate cancer, leukemias, and hematologic malignancies. Includes dedicated chapters on immune responses, innate immunity, active immunization against cancer, and cell-based therapies by leading experts. Covers key topics such as cancer immunotherapy in the presence of COVID-19, immunotherapeutics, new findings concerning the role of the microbiome in immunotherapy, advances in engineered cell-based therapies, and active immunization against cancer. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Comprehensive in scope, easy to use, and aligned to the gold standard text in the field, Creasy-Resnik's Study Guide for Maternal-Fetal Medicine is a highly effective study tool. Questions and answers written by Creasy-Resnik authors prepare you and assess your knowledge. Includes hundreds of questions and answers written by renowned experts in obstetrics, gynecology, and perinatology, with rationales linked directly to Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice, 9th Edition. Covers all topics and content in the core text, including maternal and fetal viral infections, sexually transmitted disease, and current information on genetics-all reflecting the latest evidence-based guidelines and research. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
High-Speed Railways: Environmental Impact and Pollution Prevention and Control considers environmental pollution and pollution control technology in the construction and operation of high-speed rail infrastructure. In six chapters, this new volume introduces high speed rail and environmental impact, considers environmental pollution and prevention in high speed railways, and covers the prediction, measurement and prevention of key environmental aspects of the railway. The title gives engineers the means to understand and mitigate the major environmental impacts of building and operating high-speed railways in the modern world. High-speed railways offer a low-carbon and environmentally-friendly future for public railways. However, building and operating high speed railways at scale causes stress both to the environment and to people living nearby. Impacts include noise, vibration, air and water pollution, electromagnetic radiation, and solid waste from construction sites and the normal operation of the railway. In turn, analyzing the impact of high speed rail has grown in urgency.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Critical Care**Edited by the American Association of Critical-Care Nurses and written by more than 100 critical care experts under the direction of Karen L. Johnson, PhD, RN, FAAN, this definitive reference represents the gold standard of care for procedures performed in progressive and critical care settings. It guides you through procedures common to the adult critical care environment, including those performed by advanced practice nurses, in an illustrated, step-by-step format. This edition - now in in full color - features new procedures, new and updated illustrations, and updated content throughout, reflecting the latest evidence-based guidelines and national and international protocols. Quick-reference tabs make it easier than ever to locate content quickly. This new edition integrates key AACN initiatives, such as Practice Alerts, and coordinates closely with the AACN Core Curriculum for Progressive and Critical Care Nursing, 8th Edition. Chapter-specific quick-links employ QR codes for instant access to high-quality online references. Edited by the American Association of Critical-Care Nurses, written by more than 100 expert critical care clinicians under the direction of Karen L. Johnson, PhD, RN, FAAN, and extensively reviewed by more than 100 additional critical care experts to ensure the accuracy and currency. Comprehensive coverage includes all procedures commonly performed in progressive and critical care settings, including those performed by advanced practice nurses (indicated by an AP icon). Straightforward, step-by-step organization uses consistent headings to make following a procedure (and finding the various supporting elements) quick and easy, with bulleted lists, tables, and detailed illustrations throughout to ensure that content is easy to reference and follow. Rationales for all interventions in patient and family education, assessment, patient preparation, procedure, and monitoring help students understand the rationale for every step, and a level of evidence is provided when a research base exists to substantiate an intervention, giving insight into the strength of recommendations. NEW! Additional procedures, new and updated illustrations, and updated content throughout reflect the latest evidence-based guidelines and national and international protocols. NEW! Full-color design with color reference tabs enhances navigation, plus full-color illustrations reinforce understanding. UPDATED! Key AACN initiatives, such as Practice Alerts, are integrated throughout, and content coordinates with the AACN Core Curriculum for Progressive and Critical Care Nursing, 8th Edition. NEW! Chapter-specific quick-links via QR codes provide quick access to online references, which have been updated and limited to the highest-value sources.
Focusing on high-yield information, Neuroradiology: The Core Requisites, 5th Edition emphasizes the basics to help you establish a foundational understanding of neuroradiology during rotations, prepare for the core and certifying exams, and refresh your knowledge of key concepts. This completely rewritten and reorganized edition emphasizes the essential knowledge you need in an easy-to-read format, with thorough updates that cover new imaging modalities, the latest guidelines, and integration of physics information throughout. Emphasizes the essentials in a templated, quick-reference format that includes numerous outlines, tables, pearls, boxed material, and bulleted content for easy reading, reference, and recall. Prioritizes and explains key information to help you efficiently and effectively prepare for board exams. Helps you build and solidify conceptual, technical, and interpretive core knowledge needed for imaging the brain, spine, and head and neck. Features hundreds of high-quality images, including diffusion weighted imaging, perfusion imaging, MR and CT angiography, and MR spectroscopy. Published as part of the newly reimagined Core Requisites series, an update to the popular Requisites series aimed at radiology trainees and today's busy clinicians. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text and figures from the book on a variety of devices. Any additional digital ancillary content may publish up to 6 weeks following the publication date.
Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in an easy-to-access format. Chapters cover the key topics of greatest and most frequent concern to clinicians treating newborns, delivering current, data-driven management and treatment advice in a single source relevant to the seasoned practitioner, fellow, or trainee. A highly templated format makes it easy to find exactly the information you need.  Lavishly illustrated with photos, radiographs, drawings, and charts and graphs that clarify key concepts in a helpful and accessible way. Evidence-based focus ensures that only the most reliable treatment protocols and clear-cut, data-driven guidance are included. Coverage of all relevant topics in the NICU: skin lesions, congenital anomalies, architecture/development of neonatal intensive care units, pain control, anesthesia for newborn infants, and much more. Ideal for every member of the NICU team: neonatologists, neonatology fellows, residents, and neonatal nurses, as well as all other clinicians working in the NICU, including PAs, occupational therapists, respiratory therapists, and others. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.Â
Hierarchical Modeling of Energy Systems presents a detailed methodology for hierarchical modeling of large-scale complex systems with a focus on energy systems and their expansion planning and control. General methodological principles of hierarchical modeling are analyzed, and based on this analysis, a generalized technology for the hierarchical approach is presented. The mathematical foundations of decomposition and bi-level programming, as well as the possibility of using information technologies are also considered. The theoretical propositions are demonstrated by numerous hierarchical modeling examples aimed at planning the development of the energy sector and expansion of energy systems, analyzing, and optimizing these systems, and controlling their operation. In addition, codes and sample simulations are included throughout. This is an invaluable guide for researchers, engineers, and other specialists involved in the development, control and management of energy systems, while the summary of fundamental principles and concepts in energy modeling makes this an accessible learning tool for graduate students on any course involving energy systems or energy modeling.
33rd European Symposium on Computer Aided Process Engineering: ESCAPE-33, Volume 52 contains the papers presented at the 33rd European Symposium of Computer-Aided Process Engineering (ESCAPE) event held in Athens, Greece. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students and consultants in the chemical industries.
Phosphate Rock: An Industry in Transition takes an interdisciplinary approach to dealing with the phosphate rock chain and its exploration, extraction, processing, fertilizer making, and storage and transportation. The book treats the subject from a global perspective, giving readers insights into what is happening in the emerging economies of the world and possible solutions to problems. It also provides all the parameters necessary to evaluate economic viability of undertaking a mining venture, taking into consideration demands of sustainable mining - social responsibly, environmental pollution control measures, community development, and precautions necessary for ensuring health and safety in the hazardous conditions of mining operations. In recent years, supply chain management has grown in importance as it forms tighter links in integration of key business processes from initial extraction of raw phosphate rock to end customers through different stages of process techniques. The book surveys the changes in technology, including many game-changing innovations that could transform mining.
This isn't just another book about anatomy or physiology - it's a straightforward, practical guide that answers all the common concerns and questions of every student nurse. How to Make It as a Student Nurse has evolved from the online advice provided to student nurses in the UK by well-known advocate and nurse Claire Carmichael. She has teamed up with experienced nursing lecturer Ann Marie Dodson to provide a complete guide to being a student nurse, from the application stage through to writing assignments, passing exams, undertaking clinical placements and working in a team. This wonderful new guide is packed full of invaluable advice, including how to handle your finances and juggle your caring responsibilities. The content is supported by real life case studies and vlogs to summarise key points. Engaging and easy to read - ideal for busy students Easy to navigate - takes you through each stage of the student nurse journey Covers the whole nursing degree experience Video vlogs to summarise key points Real life perspectives of nursing students Top tips on everything you will come across throughout your nursing education
In this issue of Critical Care Clinics, guest editor Dr. Hannah Wunsch brings her considerable expertise to the topic of History of Critical Care Medicine. The term "Critical Care Medicine? was first introduced in the 1950s at the University of Southern California-making 2023 the 70th anniversary of this subspecialty. This issue provides a fascinating look at important aspects of the history of the field, which originated with the concept that immediately life-endangered patients, the critically ill and injured, may have substantially better chances of survival if provided with professionally advanced minute-to-minute objective measurements. Contains 10 practice-oriented topics including early pediatric ICU care; mechanical ventilation: negative to positive and back again; airway management over the last 100 years; critical care nursing from the 1950s to the 2020s; from strict bedrest to early mobilization: a history of physiotherapy in the ICU; visiting hours and the changing place of family in the ICU; and more.
Master proven techniques for the handling and restraint of common animals! Providing clear guidelines to each procedure, Animal Restraint for Veterinary Professionals, 3rd Edition includes photos showing the exact steps needed to achieve safe restraint of animals seen in the veterinary clinic and visited on farm calls. Separate chapters are devoted to each domestic animal species, including cats, dogs, cattle, horses, sheep, goats, pigs, rabbits, rodents, ferrets, and birds. This edition adds descriptions of new restraint techniques for cats, dogs, and other species. Written by expert veterinary technician instructors C.C. Sheldon, and James A. Topel, this practical guide also includes a chapter on knot tying! Step-by-step guidelines make it easy to understand safe, commonly used restraint procedures, and include alternative restraint techniques for several different species. More than 500 full-color images and a clear, non-technical writing style depict and simplify animal restraint concepts. Comprehensive coverage includes normal and abnormal animal behavior characteristics, precautions, special handling, restraint devices, and descriptions of special restraint techniques for medical procedures such as venipuncture. Restraint Principles chapter summarizes the considerations for proper restraint, animal safety, circumstances for restraint, the effect of restraint on animals, and complications. Knot Tying chapter presents basic types of knots that may be used to safely restrain larger animals. NEW! Additional restraint techniques are included for several species. NEW! Restraint of Cats chapter is updated to include guidelines and photos for the removal of cats from a carrier, examination in a carrier, and examination in a towel on the handler's lap. NEW! Restraint of Dogs chapter is updated to include canine head control using a towel, along with safe techniques for administering intramuscular injections to aggressive dogs including the use of a door as a squeeze area and hip catch. NEW! Learning objectives, chapter outlines, and key terms are added to the beginning of each chapter.
Regarded as the ¿go-to reference on this complex and intricate procedure, Dr. William P. Chen¿s Asian Blepharoplasty and the Eyelid Crease, 4th Edition, has been thoroughly revised to include the most up-to-date and authoritative information you need to expand your practice or refine your skills. Ideal for plastic surgeons, ophthalmologists, and cosmetic dermatologic surgeons, this unique multimedia resource offers comprehensive coverage of eyelid anatomy, surgical approaches, and revision surgery¿all highlighted by more than 450 step-by-step illustrations, 35 comprehensive videos, and 10 ¿short step videos that provide operative guidance and illustrate patient outcomes over time. Revised throughout with updated case examples, select new patient photos, and updated coverage based on the recent literature. Eight new chapters cover Control of Eyelid Crease Depth During Construction; Ratios in Double Lid Segment; Revisional Asian Blepharoplasty; Paths, Pitfalls, and Solutions in Asian Blepharoplasty; Failure Analysis; An Operative Primer, and more. Contains a new paradigm of scoring suboptimal findings based on eyelid crease height, depth, and crease shape, providing realistic assessment and comparison. Step-by-step instructions for optimizing the biodynamics for eyelid crease formation; how to eliminate the prominent medial upper lid fold; removing tissues as a trapezoidal block using minimized steps; and much more. Expanded guidance on managing complications integrated throughout, with surgical pearls and summative boxes where relevant. High-quality, full-color artwork shows three-dimensional representations of key anatomy and procedural steps. Extensive collection of case studies, with before and after patient photos; plus practice worksheets, appendix tables, comprehensive references, and pearls and pitfalls throughout. 35 comprehensive videos cover primary surgery as well as revisional procedures, and can be viewed step by step or as an entire sequence. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Authored by current and former physicians at the Mayo Clinic, Faust's Anesthesiology Review, 6th Edition, is an invaluable review source for success on exams and in practice. It covers a broad range of important and timely topics in a succinct, easy-to-read format, providing the essential information you need to master the latest advances, procedures, guidelines, and protocols in anesthesiology. Provides in-depth, yet succinct clinical synopses of all topic areas found on the ABA/ASA exam, with the perfect amount of information to ensure exam success. Contains five new chapters: Principles of Preoperative Evaluation; Anesthesia for Patients who are Lactating; Peripheral Nerve Blocks of the Anterior Trunk; Sustainability in Anesthesiology and the Operating Room; and Anesthesia During a Pandemic. Covers the core knowledge needed to succeed in today's anesthesiology practice, including awake craniotomy, non-OR anesthesia (NORA), neuromodulation, using arterial pressure waveform to derive cardiac output, enhanced recovery (ERAS) pathways, chemical dependency in anesthesia personnel, lung transplantation, anesthesia for robotic surgery, and more. Includes boxes, tables, charts, and graphs throughout to provide visual guidance and summarize critical information. Features concise chapters for efficient review and effective recall, making this an ideal study tool for certification, recertification, or as a refresher for anesthesiology practice. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
The Anatomical Basis of Dentistry, 5th Edition fulfills the need for a textbook of gross anatomy written specifically for the dental profession. It features core anatomy of the entire body and in-depth chapters dealing with the head and neck and provides a solid foundation for the future dentist and review material for the dental specialty resident. The 5th edition includes a revised chapter on supplemental anatomy for the general dentist and dental specialties, such as oral and maxillofacial surgery, orthodontics, prosthodontics, periodontics, and radiology, along with updated illustrations and clinical applications. In addition, an eBook version is included with print purchase, providing access to all the text, figures, and references and the ability to search, customize content, make notes and highlights, and have content read aloud. Using a clear, accessible style, with practical Clinical Notes boxes updated to include more of a case-based approach, this book closely relates the basic science of applied anatomy to the clinical practice of dentistry and provides an excellent review for board exam preparation. Tailored content for dental practice focuses on core, need-to-know content. Regional approach to anatomy breaks down anatomical structures and body systems into easy-to-understand modules. Key cadaver dissection photographs of the head with interactive labelling clearly depict the location of anatomic structures. Review questions and answers at the end of each chapter reinforce and assess comprehension. REVISED! Chapter on clinically applied anatomy for dentists and dental specialties includes oral and maxillofacial surgery, orthodontics, prosthodontics, periodontics, and radiology. UPDATED! Clinical applications and Clinical Notes boxes provide incentive to learning and relate basic science concepts to the actual clinical practice of dentistry. NEW! An ebook version is included with print purchase, allowing access to all the text, figures, and references, as well as the ability to search, customize content, make notes and highlights, and have content read aloud. UPDATED! Enhanced and modern illustrations visually clarify key content.
The unique and award-winning Unofficial Guides series is a collaboration between senior students, junior doctors and specialty experts. This combination of contributors understands what is essential to excel on your course, in exams and in practice - as well as the importance of presenting information in a clear, fun and engaging way. Packed with hints and tips from those in the know, when you are in a hurry and need a study companion you can trust, reach for an Unofficial Guide. Candidate Briefings, Patient Briefings and Mark Schemes allows you to role play a real life OSCE exam. It walks you through each station you will encounter- complete with a briefing for the actor playing the patient, a briefing for the student, and a mark scheme and questions to ask for the examiner. Ideal for OSCE candidates as a clear, compact revision guide, this book will also make a useful day-to-day reference guide for professionals. Companion to The Unofficial Guide to Passing OSCEs 4e Provides a step-by-step, practical guide to all OSCE exams and revision Practice examples of examiner questions, with model answers, to minimise the risk of surprises on the day Written and reviewed by doctors and senior medical students - practical guidance from those in the know Facilitates practice in groups of 2-3 as if going through the real exam References COVID regulations for exams New matched stations around data interpretation and ophthalmology Multiple answers to examiner questions in each scenario
In this issue of Orthopedic Clinics, a team of eleven guest editors from the Campbell Clinic bring their considerable expertise to the topic of Managing Comorbidities. Top experts in the field cover key topics such as preventing the impact of hyperglycemia and diabetes on patients undergoing total joint arthroplasty; managing the patient with peripheral artery disease before TKA surgery; how to best utilize pediatric subspecialists; management of gout in the upper extremity; and more. Contains 12 relevant, practice-oriented topics including an update on the management and optimization of the patient with morbid obesity; managing comorbid conditions in geriatric orthopedic trauma patients; T1DM overview and perioperative management; what the orthopaedic surgeon should know about new trends in the medical management of diabetes; comorbidities in spine surgery: preoperative evaluation, treatment, and outcomes; and more. Provides in-depth clinical reviews on managing comorbidities, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In this issue of Dermatologic Clinics, guest editor Dr. Susan C. Taylor brings her considerable expertise to the topic of Diagnosing Skin Disease in Skin of Color. Top experts in the field cover key topics such as hidradenitis suppurativa; psoriasis; atopic dermatitis; diagnosing disorders of facial erythema; disorders of facial hyperpigmentation; disorders of hypopigmentation and depigmentation; and more. Contains 14 relevant, practice-oriented topics including scarring alopecia; scalp infections and inflammation; collagen vascular disease; cosmetic enhancement pitfalls; sarcoidosis; skin cancer in skin of color; disorders of children; and more. Provides in-depth clinical reviews on diagnosing skin disease in skin of color, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In this issue of Neurosurgery Clinics, guest editors Drs. Randy L. Jensen and Gabriel Zada bring their considerable expertise to the topic of Meningioma. Top experts in the field cover key topics such as genomic and epigenomic landscape of meningioma; current pathology of meningiomas; medical management of meningiomas; endoscope endonasal and keyhole surgery for skull base meningiomas; open craniotomy for meningiomas; and more. Contains 17 relevant, practice-oriented topics including management of intraventricular meningioma; spinal meningiomas; immunotherapy and other targeted therapies for meningiomas; the role of radiotherapy in the treatment of higher-grade meningioma; advanced meningioma imaging; and more. Provides in-depth clinical reviews on meningioma, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Master the critical imaging content you need to know with this thoroughly updated title in the popular Case Review series. Thoracic Imaging offers a highly illustrated, case-based preparation for board review to help residents and recertifying radiologists succeed on exams, demonstrate a clinical understanding of thoracic imaging, and improve imaging accuracy and interpretation. Cases include both common and difficult-to-diagnose disorders spanning the range of diseases impacting the thorax, including sarcoidosis, lymphoma, traumatic aortic injury, small airway disease, idiopathic interstitial pneumonias, developmental lung disease, and lung cancer. Presents more than 145 high-yield case studies organized by level of difficulty, helping you build your knowledge and confidence in stages. All cases have been refreshed and rewritten to capture the latest clinical implications and diagnostic pearls on thoracic conditions that you will be tested on. Includes multiple-choice questions, answers, and rationales that mimic the format of certification exams. Uses short, easily digestible chapters covering the full range of thoracic imaging for efficient, effective learning and exam preparation. Features hundreds of high-quality, full-color images (many new to this edition) representing a wide range of clinical situations encountered in thoracic imaging. Images include chest radiographs, CT, PET-CT, and MRI to help you expand your visual identification and diagnostic skills. Clearly see and interpret 400 high-quality, state-of-the-art images representing a wide range of clinical situations encountered in thoracic imaging. Get fresh perspectives from 200 updated or new cases reflecting the most recent changes in thoracic imaging, including PET-CT, emerging pulmonary infections, smoking-related lung diseases, Fleischner guidelines for management of incidentally detected lung nodules, and ground glass and part-solid lung nodules. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty.
Photoelectrochemical Bioanalysis: Fundamentals and Emerging Applications covers the fundamentals from a basic to advanced level, along with the latest accounting of emerging applications. As photoelectrochemical bioanalysis is a rapidly developing area with a wide range developments occurring alongside, it can be difficult for beginners to grasp the understanding of the ever-growing and continuously expanding body of knowledge. Sections detail information on applications in bioanalysis, their working principles, the methodologies of constructions and the approaches adopted with their respective advantages and disadvantages. This book will assist researchers in understanding the latest advances in the materials and engineering aspects of PCE bioanalysis. It also provides researchers with an overview of modern strategies applied for the performance enhancement of PCE materials as well as the modifications suggested to improve the potential of PCE bioanalytical techniques. Last but not least, it will assist researchers in finding gaps and potential opportunities in the field to impart novelty in their research
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