Böcker utgivna av Cold Spring Harbor Laboratory Press,U.S.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology focuses on the critical questions currently debated in the field of immune memory and vaccination. Topics include the plasticity of memory CD4 T cells, the formation of germinal centers by memory B cells, the contributions of natural killer cells to immune memory, and the influence of commensal microbiota on immune responses. Several contributors respond to each question, providing a variety of fresh, concise perspectives on each topic.

Color and learn! Welcome to your familyDLall the wonderful inhabitants of Planet Earth. We share something very special with every human being, animal, plant, and microscopic creature. What do we share with all living things? We are all GENE MACHINES! Discover all the books in the ENJOY YOUR CELLS series, each available in coloring book and full-color formats! Recommended for ages 7 and up.

Epilepsy affects millions worldwide and represents a variety of disorders characterized by seizures. This book examines the neurobiological bases of these conditions and current research into treatment strategies.

This collection reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Contributors discuss how cells coordinate signaling pathways, membrane trafficking, and cytoskeletal remodeling to ensure proper spatial arrangement of cellular components. Processes such as transcytosis, exocyst-mediated vesicle trafficking, and endosomal sorting are covered in detail. Throughout, the focus is on epithelial cells and how polarity mechanisms facilitate the development of their apical and basolateral surfaces, tube formation, exchange of waste and nutrients, and the generation and maintenance of specialized structures at the cell surface.

The machinery that controls how DNA is packaged and genes are activated plays an important role in cancer. This book examines the functions of components of this machinery, how they can be dysregulated, and the prospects for targeting them therapeutically.

CRISPR-Cas-based techniques are revolutionizing molecular biology and genetics. The technology is based on a bacterial immune system that uses specific guide RNAs to target foreign DNA sequences for degradation. It has been adapted for genetic engineering and has a wide variety of applications in all fields of biology and the development of new therapeutic approaches.

Hepatitis B affects hundreds of millions of individuals worldwide and is a leading cause of liver cancer. This book examines our understanding of the biology of the Hepatitis B virus that causes the disease, the immune responses it elicits, and its role in liver cancer. It also discusses the related Hepatitis Delta virus and its effects.

As universities increasingly spin off biotech companies and academics work more closely with these companies and the pharma industry, it is essential that they gain an understanding of intellectual property law and patenting. This book introduces the basic ideas and discusses how they apply to biomedical research and product development in the age of genomics.

Recent work has improved our understanding of the molecular and cellular bases of heart development and function. This book discusses these advances and the implications for diagnosis and treatment of heart disease, including stem cell therapy, tissue engineering, and transplantation.

Neuroscientists must now routinely use advanced molecular biology and tissue culture techniques in their research. This book provides a detailed practical guide to both fundamental and cutting-edge methods in these areas. Aimed specifically at neuroscientists, it includes protocols for working with DNA and RNA, cell purification and tissue culture, and microscopy, as well as numerous organism-specific techniques.

One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, andthe development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

An essential guide for students in the life sciences, established researchers, and career counselors, this resource features discussions of job security, future trends, and potential career paths. Even those already working in the industry will find helpful information on how to take advantage of opportunities within their own companies and elsewhere.

Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases.

The majority of PhDs trained in biomedical sciences do not remain in academia. They are now presented with a broad variety of career options, including science journalism, publishing, science policy, patent law, and many more. This book examines the numerous different careers that scientists leaving the bench can pursue, from the perspectives of individuals who have successfully made the transition. In each case, the book sets out what the job involves and describes the qualifications and skills sets required.

Bacterial pathogens cause numerous human diseases. This collection from Cold Spring Harbor Perspectives in Medicine surveys the spectrum of bacterial pathogens from Salmonella and Shigella to Heliobacter pylori. It examines the basic biology of these parasites, their virulence mechanisms and the host's response to infection. The effectiveness of antibiotics and vaccine strategies are also covered, along with the novel antimicrobial therapies that are being developed.

During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of "cellular ingestion" is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. Pathogens (e.g., HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and post-endocytic trafficking, and how they regulate cellular and organismal physiology. Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. They review the numerous machineries (e.g., Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered. This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process.

Cell death plays a critical role in development, normal physiology and many diseases, including cancer. Research in this area is rapidly advancing and involves a variety of specific techniques. This manual provides a step-by-step guide to these techniques, along with background information informing researchers when they should be used.

In the 1920s, the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world's leading center for the study of human genetics and susceptibility to disease. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov's The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the purge of many of the country's finest biologists and a major setback to the development of science internationally.

Parkinson's Disease is an incurable neurodegenerative disease characterized by a progressive loss of dopaminergic neurons that leads to slowness of movement, muscle rigidity, and tremors. Insoluble aggregates of proteins such as alpha-synuclein accumulate in the affected neurons, which also appear to be subject to oxidative stress. This collection from Cold Spring Harbor Perspectives in Medicine discusses recent work that has begun to uncover the molecular mechanisms that underlie the condition, including studies that implicate dysfunction of mitochondrial proteins such as parkin and pink1.