Böcker utgivna av Birkhauser Verlag AG

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors.

This volume provides a comprehensive, state-of-the art review of the field of cell therapy.

This book shows the importance of studying semilocal convergence in iterative methods through Newton's method and addresses the most important aspects of the Kantorovich's theory including implicated studies.

Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ¿

This book examines the design of two care pathways to establish how key principles associated with systems thinking, quality improvement, and supply chain management can improve the design of these services.

This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses.

In this book, Vladimir Maz'ya describes the first thirty years of his life. He describes his formative years in the Soviet Union, the awakening of his passion for mathematics and his early achievements, presenting, in the process, a vivid picture of the time.

This book contains selected papers based on talks given at the "Representation Theory, Number Theory, and Invariant Theory" conference held at Yale University from June 1 to June 5, 2015.

Utilizing the most current evidence, this practical book is the first publication of its kind to focus exclusively on the clinical and laboratory evaluation and therapy of thyroid nodules, including advances in evaluation and controversies in management.

This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer.

This practical resource provides the latest evidence, management strategies and recommendations for the treatment of disorders of the adrenal glands, including related physiology, genetics and pharmacology.

This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis.

This book presents the theory of waves propagation in a fluid-saturated porous medium (a Biot medium) and its application in Applied Geophysics.

This book explores the idea that while we see the vampire as a hero of romance, or as a member of an oppressed minority struggling to fit in and acquire legal recognition, the vampire has in many ways changed beyond recognition over recent decades due to radically shifting formations of the sacred in contemporary culture.

In studying this equation, all the necessary material is introduced in the most self-contained way possible, giving precise references to the literature when necessary.The results presented are original, but no particular prerequisite or knowledge of the previous literature is needed to read this text.

The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis.

This authoritative reference presents the modern concepts of mesenchymal stem cells (MSCs) and biomaterials as they pertain to the dental field. The book is organized around three main topics: MSCs biology, advanced biomaterials, and clinical applications. The chapters present basic information on stem cell biology and physiology, modern biomaterials that improve bone tissue regeneration, the biomatrices likeplatelet-rich fibrin (PRF) used to functionalize the biomaterials surface, the strategic and safe intraoral seats of harvesting, the new sources for MSCs, as well as the future perspectives and new challenges in these exciting fields. The contributors are top scientists with a great deal of experience in regenerative dentistry and biomedical research. They offer an international perspective and are richly cross-disciplinary, representing academia, research, and industry. MSCs and Innovative Biomaterials in Dentistry is indispensable reading for students, researchers, and clinicians who need to stay up-to-date on the cutting-edge developments of tissue engineering and regenerative medicine applied to dental sciences.

This volume contains extended abstracts outlining selected talks and other selected presentations given by participants throughout the "Intensive Research Program on Advances in Nonsmooth Dynamics 2016", held at the Centre de Recerca Matemàtica (CRM) in Barcelona from February 1st to April 29th, 2016. They include brief research articles reporting new results, descriptions of preliminary work or open problems, and outlines of prominent discussion sessions. The articles are all the result of direct collaborations initiated during the research program.The topic is the theory and applications of Nonsmooth Dynamics. This includes systems involving elements of: impacting, switching, on/off control, hybrid discrete-continuous dynamics, jumps in physical properties, and many others. Applications include: electronics, climate modeling, life sciences, mechanics, ecology, and more. Numerous new results are reported concerning the dimensionality and robustness of nonsmooth models, shadowing variables, numbers of limit cycles, discontinuity-induced bifurcations and chaos, determinacy-breaking, stability criteria, and the classification of attractors and other singularities. This material offers a variety of new exciting problems to mathematicians, but also a diverse range of new tools and insights for scientists and engineers making use of mathematical modeling and analysis.The book is intended for established researchers, as well as for PhD and postdoctoral students who want to learn more about the latest advances in these highly active areas of research.

This book is intended for established researchers, as well as for PhD and postdoctoral students who want to learn more about the latest advances in these highly active areas of research.The two parts of the present volume contain extended conference abstracts corresponding to selected talks from the "Biostatnet workshop on Biomedical (Big) Data" and from the "DoReMi LD-RadStats: Workshop for statisticians interested in contributing to EU low dose radiation research", the first held at the Centre de Recerca Matemàtica (CRM) in Barcelona from November 26th to 27th, 2015, and the second held at the Institut de Salut Global ISGlobal (former CREAL) from October 26th to 28th, 2015. Most of them are brief articles, containing preliminary presentations of new results not yet published in regular research journals.The first part is devoted to the challenges of analyzing the so called "Biomedical Big Data", large amounts of biomedical and health data that are generated every day due to the use of recent technological advances such as massive genomic sequencing, electronic health records or high-resolution medical imaging, among others. The analysis of this information poses significant challenges to researchers in the field of biostatistics, bioinformatics, and signal processing. Furthermore, other relevant challenges of biostatistical research, not necessarily involving big data, are also discussed. The second part is dedicated to low dose radiation research, where there is a need to fully understand sources of uncertainty and how to characterise them before they can be reduced. Further, formal uncertainty analysis has the potential to provide a common platform for multidisciplinary research in this field.

The second of a two volume set on novel methods in harmonic analysis, this book draws on a number of original research and survey papers from well-known specialists detailing the latest innovations and recently discovered links between various fields. Along with many deep theoretical results, these volumes contain numerous applications to problems in signal processing, medical imaging, geodesy, statistics, and data science. The chapters within cover an impressive range of ideas from both traditional and modern harmonic analysis, such as: the Fourier transform, Shannon sampling, frames, wavelets, functions on Euclidean spaces, analysis on function spaces of Riemannian and sub-Riemannian manifolds, Fourier analysis on manifolds and Lie groups, analysis on combinatorial graphs, sheaves, co-sheaves, and persistent homologies on topological spaces. Volume II is organized around the theme of recent applications of harmonic analysis to function spaces, differential equations, and data science, covering topics such as:The classical Fourier transform, the non-linear Fourier transform (FBI transform), cardinal sampling series and translation invariant linear systems.Recent results concerning harmonic analysis on non-Euclidean spaces such as graphs and partially ordered sets.Applications of harmonic analysis to data science and statisticsBoundary-value problems for PDE's including the Runge¿Walsh theorem for the oblique derivative problem of physical geodesy.

The first of a two volume set on novel methods in harmonic analysis, this book draws on a number of original research and survey papers from well-known specialists detailing the latest innovations and recently discovered links between various fields. Along with many deep theoretical results, these volumes contain numerous applications to problems in signal processing, medical imaging, geodesy, statistics, and data science. The chapters within cover an impressive range of ideas from both traditional and modern harmonic analysis, such as: the Fourier transform, Shannon sampling, frames, wavelets, functions on Euclidean spaces, analysis on function spaces of Riemannian and sub-Riemannian manifolds, Fourier analysis on manifolds and Lie groups, analysis on combinatorial graphs, sheaves, co-sheaves, and persistent homologies on topological spaces. Volume I is organized around the theme of frames and other bases in abstract and function spaces, covering topics such as:The advanced development of frames, including Sigma-Delta quantization for fusion frames, localization of frames, and frame conditioning, as well as applications to distributed sensor networks, Galerkin-like representation of operators, scaling on graphs, and dynamical sampling.A systematic approach to shearlets with applications to wavefront sets and function spaces.Prolate and generalized prolate functions, spherical Gauss-Laguerre basis functions, and radial basis functions.Kernel methods, wavelets, and frames on compact and non-compact manifolds.

Now in a fully revised and updated second edition, written and editing by leading experts in the field, this comprehensive and practical text brings together the latest guidelines and recommendations on the benefits of exercise and physical activity in the management of diabetes and its complications, providing both the researcher and practitioner with evidence-based information that is both theoretically and clinically useful. Part one sets the stage by discussing the epidemiology and prevention of type 2 diabetes and the metabolic syndrome. The physiological effects of exercise in type 2 diabetes are covered in part two, covering molecular mechanisms, adiposity, sex differences, cardiovascular consequences and musculoskeletal changes. Part three addresses practical issues that are essential in order to safely engage patients with diabetes in exercise-related research protocols and clinical programs, including DPP and LOOK Ahead, nutrition, behavioral changes, and guidelines for exercise testing. The final section examines special considerations for exercise in people with diabetes, such as those with neuropathy, cardiac issues and peripheral artery disease. Taken together, Diabetes and Exercise, Second Edition brings together the latest information and thought leaders in the field to create a unique and useful text for all clinicians, researchers and therapists working to integrate physical activity into their management strategies for the increasing number of diabetic patients.

This book combines the current knowledge on the role of lipids in stem cell pluripotency and differentiation.

The construction of solutions of singularly perturbed systems of equations and boundary value problems that are characteristic for the mechanics of thin-walled structures are the main focus of the book.

Topics include Columbeau algebras, ultra-distributions, partial differential equations, micro-local analysis, harmonic analysis, global analysis, geometry, quantization, mathematical physics, and time-frequency analysis.