This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells' surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.
Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology.
Advanced Calculus for Mathematical Modeling in Engineering and Physics: With Discrete and Numerical Analogies introduces the principles and methods of advanced calculus for mathematical modeling through a balance of theory and application using a state space approach with elementary functional analysis. This framework facilitates a deeper understanding of the nature of mathematical models, and of the behavior of their solutions. The work provides a variety of advanced calculus models for mathematical, physical science, and engineering audiences, with discussions on how calculus-based models and their discrete analogies are generated. This valuable textbook offers scientific computations driven by Octave/MATLAB script.
As Bayesian techniques become more common across a variety of fields, it becomes important for experts in those fields to understand those methods. An Introductory Handbook of Bayesian Thinking brings Bayesian thinking and methods to a wide audience beyond the mathematical sciences. Appropriate for students with some background in calculus and introductory statistics, particularly for nonstatisticians with a sufficient mathematical background, the text provides a gentle introduction to Bayesian ideas with a wide array of supporting examples from a variety of fields.
Cutting Edge Artificial Intelligence, Spatial Transcriptomics and Proteomics Approaches to Analyze Cancer, Volume 163 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting topics on the Impact of thermal processing on food flavonoids, Bioinformatics and bioactive peptides from foods: does it work together?, Food off-flavor volatiles generation, characterization and advances in novel strategies for mitigating off-flavor perception, Innovations in Food Packaging for a Sustainable and Circular economy, Upcycling of seafood side streams for circularity, Edible insects in foods, Effect of novel food processing technologies on Bacillus cereus spores, and more.
Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
Advances in Rhizostomeaen Jellyfish Research, Volume 97 in the Advances in Marine Biology series, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors.
Vertebrate Pattern Formation, Volume 159 in the Current Topics in Developmental Biology series, highlights advances in the field, with this volume presenting interesting chapters on timely topics, including Hox genes patterning the vertebrate body, Endodermal patterning, The use of organoids/gastruloids to understand development, Cell shape and movements controlling development, Neural crest and placodes in vertebrate development, Patterning of the neural tube, Non-canonical Wnt signaling in axial extension, The control of transitions along the main body axis, Emergence of a left-right symmetric body plan in vertebrate embryos, Formation of the vascular system, Generation of patterns in the paraxial mesoderm, and more.
Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors
Glycation, Volume 125 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.
Advances in Imaging and Electron Physics, Volume 218 merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. The series features articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, digital image processing, electromagnetic wave propagation, electron microscopy and the computing methods used in all these domains. Specific chapters in this release cover Phase retrieval methods applied to coherent imaging, X-ray phase-contrast imaging: a broad overview of some fundamentals, Graphene and borophene as nanoscopic materials for electronics - with review of the physics, and more.
Domino Effect: Its Prediction and Prevention, Volume Five in the Methods in Chemical Process Safety series, focuses on the process of learning from experience, including elements of process safety management, human factors in the chemical process industries, and the regulation of chemical process safety, including current approaches. Users will find this book to be an informative tool and user manual for process safety for a variety of professionals. This new release focuses on Domino effect - Case histories and accident statistics, the state-of-the-art in domino effect modeling, Fire Driven Domino Effect, Mitigation of Domino Effect, and much more.
Introduction to Optimum Design, Fifth Edition is the most widely used textbook in engineering optimization and optimum design courses. It is intended for use in a first course on engineering design and optimization at the undergraduate or graduate level within engineering departments of all disciplines, but primarily within mechanical, aerospace and civil engineering. The basic approach of the text presents an organized approach to engineering design optimization in a rigorous yet simplified manner, illustrating various concepts and procedures with simple examples and demonstrating their applicability to engineering design problems. Formulation of a design problem as an optimization problem is emphasized and illustrated throughout the text. Excel and MATLAB are featured as learning and teaching aids. This new edition has been enhanced with new or expanded content in such areas as reliability-based optimization, metamodeling, design of experiments, robust design, nature-inspired metaheuristic search methods, and combinatorial optimizaton.
International Review of Movement Disorders series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
This is a study of the evolution of the principles and techniques of cranial surgery from Hippocrates to the nineteenth century. The methods of conveying information by text and image are considered.
Recent Advancements In Waste Water Management: Nano-based Remediation, Volume Ten highlights new advances in the field, with this new volume presenting interesting topics in chapters including Biogenic nanoparticles for dye removal, Membrane process for wastewater treatment, Nano-biocatalysts for wastewater remediation and redefining of pollutants, Nanobiosorption of toxic cations from wastewater, Nanotechnologies to mitigating the risks of emerging pollutants, Bioremediation of insecticides and herbicides using nanomaterials, Magnetically responsive nanocomposites for robust environmental remediation, Metal-organic frameworks for oil-water separation, and Electrochemical approaches in wastewater treatment. Other chapters focus on important tools and techniques for characterization of wastewater, Heterogenous catalysis for pharmaceutical wastewater treatment, Essential roles of graphene and graphene based membrane in water desalination and treatment, Contamination removal from waste water using electrochemical approaches, Combined treatments for wastewater treatment process, Water treatment and environmental applications of two-dimensional metal carbides, Oil-refinery wastewater treatment in a biofilm membrane bioreactor, Hybrid adsorptive-photocatalytic nanoparticle technology for remediation of organic pollutants, Green synthesis of nanoparticles for the remediation of organic pollutants in wastewater by adsorption, and more.
The Mechanisms Behind Developing Dependence, Sub-groups, and Novel Approaches to Treatment, Volume 174 in the Neurobiology of Alcohol Abuse series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Substitution therapy in alcohol treatment, with a focus on mechanisms and possibilities, Designing and analyzing studies on treatments for alcohol dependence, The harm reduction approach for treatment of alcohol dependence, Current treatments for alcohol dependence, with a suggested focus on mechanisms and possibilities, Metabolomics in relation to alcohol dependence with focus on possibilities for precision medicine, and Repurposing drugs for treatment of alcohol dependence.
Organizers in Development, Volume 157 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The organizer: what it meant, and means, to developmental biology, Organizers/signaling regions that pattern the limb, Organizers/signaling regions in the branchial arches, The notochord/floor plate as a possible organizer, Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula, and more.
Immunobiology of COVID19, Volume 202 in the Progress in Molecular Biology and Translational Science Series provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, lifecycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume will serve as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health.
Physics in Biology and Medicine, Sixth Edition includes new, revised material, and corresponding exercises on many exciting developments in the field. New sections cover biomechanics, biotribology, frictional properties of biological materials, 3-D printing and its use in medicine, new materials in dentistry, microfluidics, bioelectronic medicine, microsensors, and microscopy. This revised edition delivers helpful and engaging additions to the role and importance of physics in biology and medicine, including new coverage on metamaterials, metabolism, and environmental science. It is ideal for courses in biophysics, medical physics, and related subjects.
Topological Insulator and Related Topics, Volume 108 in the Semiconductors and Semimental series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Majorana modes at the ends of one dimensional topological superconductors, Optical/electronic properties of Weyl semimetals, High magnetic fields to unveil the electronic structure, magnetic field-induced transitions, and unconventional transport properties of topological semimetals, New aspects of strongly correlated superconductivity in the nearly flat-band regime, Anomalous transport properties in topological semimetals, Pseudo-gauge field and piezo-electromagnetic response in topological materials, Topological Gapped States Protected by Spatial Symmetries, and more.
Adrenal Gland, Volume 124 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
The goal for this special edition of Progress in Brain Research extends beyond merely probing the yet-to-be-uncovered links between physical exercise and cognitive improvement. We aim to advance our knowledge, pushing the envelope of what is currently understood. We are particularly focused on how purposefully structured physical activities, carefully chosen participant groups, and specific cognitive areas can optimize the cognitive and mental health benefits derived from physical exercise. The inaugural volume of this series introduces 3 review articles and 7 original pieces of research, encompassing both behavioral experiments and neuroimaging studies. Our focus is on experimental research that sheds light on the immediate and long-term impact of physical exercise on cognition as well as expert opinions and systematic reviews that compile current findings and suggest avenues for upcoming research.
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