Space Geodesy for Environmental Monitoring Volume, Volume 65 in the Advances in Geophysics series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors and covering topics such as GNSS for natural hazard mitigation, Space & Earth Data for Global Sea level change monitoring: Current Approaches, Challenges, and Future Prospects, and Crowdsourcing GNSS for geophysical applications.
Advances in Ecological Research, Volume 70 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors
Plant Biochemistry, Sixth Edition examines the molecular mechanisms of photosynthesis and highlights and expands this view to all facets facilitating plant life. It delivers the fundamental knowledge of plant biochemistry and explains the biological processes of life, including growth, development, senescence, and interactions between organisms and the environment, with chemical reactions. This book is suitable for advanced undergraduates and graduate students in plant physiology, plant pathology, plant cell biology, and other plant sciences, researchers in industries actively involved in agribusiness, other biotechnology enterprises, and researchers in agronomy, agriculture, plant development and related areas. Covering a broad spectrum of topics in plant biochemistry, this book explores photosynthesis, energy metabolism, carbohydrate synthesis, photorespiration, starch biosynthesis and degradation, sulfate assimilation and nitrogen and nitrate assimilation and biosynthesis of plant proteins. The new edition delineates areas of latest and future research and includes a new and cutting-edge chapter on chlorophyll degradation.
Unveiling the Proteolytic Networks of Parasites, Volume 125 presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms. Top researchers in the field conduct multifaceted examinations, shedding light on the distinct roles of these proteases within significant parasite groups, including malaria, trematodes, nematodes, and blood-feeding arthropods. Chapters in this new release include Bioinformatic analysis of proteases across multiple helminth species: a case study using Wormbase, UniProt and Merops databases, Proteasomes of parasites, Proteases of Trematodes as a promising drug targets-tentative title, Astacins, and metalloproteases in nematodes, and Proteases of bloodfeeding arthropods.
Vitamin D and Health, Volume 109 reviews the versatility of vitamin D in enhancing the immune system and its potential role in combating many chronic diseases. While vitamin D's role in enhancing bone health is well established, recent studies demonstrated the safety and efficacy of peri-operative vitamin D supplementation in cardiac patients and its impact on post-operative outcomes. Chapters in this new release include discussions on Vitamin D and Immune Function, Vitamin D and Bone Heath, Vitamin D and Cardiovascular Disease, Vitamin D and Cancer, Vitamin D and Diabetes, Vitamin D and Neurological Diseases, Vitamin D and Celiac Disease, and much more.
Methods for Monitoring Mitochondrial Functions During Pathogen Infection, Volume 188 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Mitochondrial Labeling with Fluorescent Proteins for Enhanced Morphological Characterization and Visualization of Intercellular Mitochondrial Transfer, Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila, Quantitative assessment of mitochondrial membrane potential in macrophages in sepsis, Quantification of mitochondrial reactive oxygen species in macrophages during sepsis, and much more. Additional chapters cover Quantification of intracellular and mitochondrial ATP content in macrophages during lipopolysaccharide-induced inflammatory response, Analysis of cytosolic mtDNA release during Staphylococcus Aureus infection, Monitoring mitochondria dynamics upon infection using a tomographic approach, A screening system to determine bacterial effects on MADCAM1 expression by high endothelial venule cells, Isolation of mitochondria from Mycobacteria infected cells, Monitoring mitochondrial localization of Mycobacterial proteins, and more.
The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more. Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/development of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.
Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies, Volume 161 in the Advances in Cancer Research series, covers timely topics such as The Prostate Cancer Tissue N-glycome as a Source of Biomarkers, a Progression from Normal to Metastatic Disease, Multiplexed Targeted Proteomics for Prostate Cancer Biomarker Verification, MRI for the Detection of Clinically Significant Prostate Cancer: Update and Future Directions, Genetic and epigenetic factors for prostate cancer progression, Epigenetic regulation of androgen dependent and independent prostate cancer, Molecular Landscape of Prostate Cancer Bone Metastasis, Future of radioligand Therapy in PC, and more. Additional chapters of note include Advancements in Computer Vision and Pathology: Unraveling the Potential of Artificial Intelligence for Precision Diagnosis and Beyond and Extracellular Vesicles in Prostate Cancer.
Grapevine: Added-Value and Applications, Volume 111 in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters on exciting and timely topics such as Biorefinery based bioproducts and future prospective of vineyard and winery waste, Side-streams of wine industry: insights and learned lessons for making real the vision of reliable pharmacological applications, Grapevine as a natural resource in the cosmetic industry, Biology of the main grapevine viruses and their effects on vine growth, yield, and grape chemical composition, Table grapes: Health implications and approaches to improve the quality during the cultivation, and more. Additional sections cover topics such as Controlling authenticity throughout the wine production chain and Wine consumption versus health: the dilemma.
Metalloproteins account for nearly half of all proteins in living organisms. Protein metal-binding sites are responsible for catalyzing some of the most important functions such as photosynthesis, respiration, water oxidation, molecular oxygen reduction, nitrogen fixation, etc. Motor proteins are another class of important proteins that can move along the cytoplasm of cells. They convert chemical energy into mechanical work by the hydrolysis of ATP. Much effort has been devoted toward understanding the structure and function of metalloproteins and motor proteins. The ultimate test is to utilize this knowledge to design new metalloproteins and motor proteins that reproduce structures and functions of native ones. While it is much more challenging to design these two groups of proteins compared to the rest of proteins, much progress has been made in this field, particularly toward functional design, thanks to recent progress in areas such as computational and structural biology. This thematic volume focuses on recent advances in studying metalloproteins and motor proteins, their roles in different pathologies and drug-resistance.
Up and Running with AutoCAD(R) 2025: 2D and 3D Drawing, Design and Modeling presents a combination of step-by-step instructions, examples, and insightful explanations. The book emphasizes core concepts and practical application of AutoCAD in engineering, architecture, and design. Equally useful in instructor-led classroom training, self-study, or as a professional reference, the book is written by a long-time AutoCAD professor and instructor with the user in mind.
Coulomb Interactions in Particle Beams, Volume 230, the latest release in the Advances in Imaging and Electron Physics series, merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. The series features articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains
Special Volume on Kogia Biology, Part Two, Volume 97 presents reviews on all aspects of marine biology. Published since 1963, this serial updates on marine biology, fisheries science, ecology, zoology and biological oceanography. Topics include Stranding data of Kogia spp. from the seas around Japan, The biology of pygmy sperm whales (Kogia breviceps) from New Zealand waters, Age, growth and reproduction of pygmy (Kogia breviceps) and dwarf (K. sima) sperm whales stranded in South Africa, The fast lane revisited: life history strategy of Kogia spp, and Stomach content analysis of pygmy and dwarf sperm whales and its ecological implications: is there niche partitioning?
Advances in Microbial Physiology, Volume 84 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include Mycobacterial Efflux systems, New insights in bacterial organophosphorus cycling: from human pathogens to environmental bacteria, Link between gut sulfidogenic bacteria and disease, The Formate-H2 Axis and its Importance for Microbial Physiology, Physiology of diazotrophs, Antibiotic efficacy, and Microbial metabolites as modulators of host physiology.
Advances in Heat Transfer, Volume 57 presents the latest in a serial that highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors.
Advances in Motivation Science, Volume Eleven, the latest release in the Motivation Science series, contains interesting articles that cover topics such as An Ecology of Meaning: An Integrative Framework for Understanding Human Motivations, Beer AMS Quest for Self Knowledge, Boundary conditions of the rational model Finding the limits of rationality, Growth goals: A review of the construct Predictors, Consequences, and Intervention, Pragmatic Prospection Theory, Research, and Practice, and The Quest for Self-Knowledge What Do We Want to Know (and not Know) About Ourselves.
This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells' surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.
Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology.
Advanced Calculus for Mathematical Modeling in Engineering and Physics: With Discrete and Numerical Analogies introduces the principles and methods of advanced calculus for mathematical modeling through a balance of theory and application using a state space approach with elementary functional analysis. This framework facilitates a deeper understanding of the nature of mathematical models, and of the behavior of their solutions. The work provides a variety of advanced calculus models for mathematical, physical science, and engineering audiences, with discussions on how calculus-based models and their discrete analogies are generated. This valuable textbook offers scientific computations driven by Octave/MATLAB script.
As Bayesian techniques become more common across a variety of fields, it becomes important for experts in those fields to understand those methods. An Introductory Handbook of Bayesian Thinking brings Bayesian thinking and methods to a wide audience beyond the mathematical sciences. Appropriate for students with some background in calculus and introductory statistics, particularly for nonstatisticians with a sufficient mathematical background, the text provides a gentle introduction to Bayesian ideas with a wide array of supporting examples from a variety of fields.
Brains and Machines: Towards a unified Ethics of AI and Neuroscience provides a comprehensive overview of concepts and ethical issues at the intersection of two emerging technological trends in the 21st century: AI and neurotechnology. In line with recent advances across both fields, debates about philosophical, ethical, regulatory and social issues raised by neuroscience and AI have considerably expanded in the past decade. Yet, despite many intersections and fruitful interactions between the two scientific domains, ethical debates about neuroscience and AI have mostly moved in parallel. This volume assembles voices from various disciplines to provide a more unified view and offer novel perspectives on two complementary lines of discourse. The volume provides scientific background by outlining the state of the art of applying AI in the field of neuroscience and discussing instances where findings and debates from neuroscience provide cues and inspiration to the study of AI. Based on this background, the book then addresses conceptual frameworks, identifies ethical challenges at the intersection of neuroscience and AI, and highlights challenges and opportunities of finding common ground in interdisciplinary settings.
Advances in Rhizostomeaen Jellyfish Research, Volume 97 in the Advances in Marine Biology series, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors.
Natural Behavior, Volume 66 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. There is a long history of studying natural behavior in science. In 1872, Charles Darwin documented his observations on the development of his children in words, which was published in an article titled "A Biographical Sketch of an Infant." Traditionally, observational studies like this had been viewed as insightful but also criticized as not objective and quantitative. More recently, building on advanced computation, the contemporary approaches to studying natural behavior in the real world delivered quantitative results. New sensing and wearable technologies allow researchers to collect high-density data in everyday contexts. With technological advances, we can scale up and obtain quantitative results from real-world data. This volume contains a collection of papers on studying natural behavior of child development. Those papers aim at understanding and predicting behavior and cognition as it occurs within complex real-world situations. Compared with findings from laboratories, the results derived from natural behavior are remarkably reliable, which provides an answer to the reproducibility crisis in science. Moreover, the findings based on natural behavior can be directly applied to the real world, especially in the health and education domains.
Vertebrate Pattern Formation, Volume 159 in the Current Topics in Developmental Biology series, highlights advances in the field, with this volume presenting interesting chapters on timely topics, including Hox genes patterning the vertebrate body, Endodermal patterning, The use of organoids/gastruloids to understand development, Cell shape and movements controlling development, Neural crest and placodes in vertebrate development, Patterning of the neural tube, Non-canonical Wnt signaling in axial extension, The control of transitions along the main body axis, Emergence of a left-right symmetric body plan in vertebrate embryos, Formation of the vascular system, Generation of patterns in the paraxial mesoderm, and more.
Glycation, Volume 125 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.
Advances in Imaging and Electron Physics, Volume 218 merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. The series features articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, digital image processing, electromagnetic wave propagation, electron microscopy and the computing methods used in all these domains. Specific chapters in this release cover Phase retrieval methods applied to coherent imaging, X-ray phase-contrast imaging: a broad overview of some fundamentals, Graphene and borophene as nanoscopic materials for electronics - with review of the physics, and more.
Domino Effect: Its Prediction and Prevention, Volume Five in the Methods in Chemical Process Safety series, focuses on the process of learning from experience, including elements of process safety management, human factors in the chemical process industries, and the regulation of chemical process safety, including current approaches. Users will find this book to be an informative tool and user manual for process safety for a variety of professionals. This new release focuses on Domino effect - Case histories and accident statistics, the state-of-the-art in domino effect modeling, Fire Driven Domino Effect, Mitigation of Domino Effect, and much more.
Introduction to Optimum Design, Fifth Edition is the most widely used textbook in engineering optimization and optimum design courses. It is intended for use in a first course on engineering design and optimization at the undergraduate or graduate level within engineering departments of all disciplines, but primarily within mechanical, aerospace and civil engineering. The basic approach of the text presents an organized approach to engineering design optimization in a rigorous yet simplified manner, illustrating various concepts and procedures with simple examples and demonstrating their applicability to engineering design problems. Formulation of a design problem as an optimization problem is emphasized and illustrated throughout the text. Excel and MATLAB are featured as learning and teaching aids. This new edition has been enhanced with new or expanded content in such areas as reliability-based optimization, metamodeling, design of experiments, robust design, nature-inspired metaheuristic search methods, and combinatorial optimizaton.
DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist
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