The discovery of valproate.- The pharmacology of valproate.- Pharmacological effects and mechanisms of action.- Chemistry and biotransformation.- Absorption, distribution and excretion.- Toxicity.- Clinical use of valproate.- Valproate in the treatment of epilepsies in children.- Treatment of epilepsies in adults.- Valproate use in psychiatry: A focus on bipolar illness.- Valproate in the treatment of headache.- Adverse effects and interactions with other drugs.- The future of valproate.
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