Böcker av Shein-Chung (Duke Univ Chow

-A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.-

Written by one of the preeminent experts in the field, this book covers commonly encountered controversial statistical issues in clinical trials and, whenever possible, makes recommendations to resolve these problems. It focuses on issues occurring at various stages of clinical research and development, including early-phase clinical development

"Focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It will cover current issues, and recent development in analytical similarity assessment"--

Details statistical inference of linear models including parameter estimation, hypothesis testing, confidence intervals, and prediction. This work discusses the application of statistical theories and methodologies to various linear models such as the linear regression model, the analysis of variance model, and the analysis of covariance model.