Böcker av Buddhi Prakash Jain

Scaffold proteins assemble vanous signaling molecules into a signalosome and activate signal transduction cascade. These proteins thus provide platforms for receptors, kinases, phosphatases and other effectors into a functional modules (Good et al., 2011). Scaffold proteins are thus key components ofsignaling networks. Among various domain structures in scaffolding proteins, one commonly found is WD40 repeat. Proteins harboring this domain often act as signaling scaffold in which the WD40 repeat domain form a beta propeller structure for assembling signaling molecules.

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.