Böcker av Adler Brown

The nervous system is a highly complex network of nerves that coordinates actions and sensory information by transmitting signals to and from various parts of the body. Random molecular damage that steadily accumulates with age drives the ageing process at the cellular level. Many molecular mechanisms are involved and exogenous factors, like stress, also play a role in the aging process. The nervous system at the cellular level comprises a special cell called a neuron, which transmits signals to the other cells. Many physical, chemical, or biological changes in the status of neurons characterize brain aging. It is manifested in the form of deterioration in cognitive function and dementia. Dendritic regression in pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia are the common features of brain aging. The consequence of molecular and cellular alterations in brain aging is characterized by a plethora of anatomical changes, such as significant neuronal loss in hippocampus and neocortex. This book provides comprehensive insights on the molecular and cellular mechanisms of aging. The readers would gain knowledge that would broaden their perspective about this area of study.

Aging is the process of growing older. It is a risk factor for most prevalent neurodegenerative diseases, such as mild cognitive impairment, dementias involving Alzheimer's disease, cerebrovascular disease, Parkinson's disease, and Lou Gehrig's disease. The brain is a complicated organ that is made up of many different types of tissue and matter. The function of various tissues in brain may be more or less susceptible to age- induced changes. The structure of brain's network is formed through anatomical connection of the neurons. The aging of brain is a complex process that begins early in life and accelerates with age, affecting everything from the subcellular to the organ level. Brain volume loss, cortical thinning, white matter degradation, loss of gyrification, and ventricular enlargement are morphological symptoms of brain aging. Neuron cell shrinking, dendritic degeneration, demyelination, small vessel disease, metabolic slowing, microglial activation, and the formation of white matter lesions are pathophysiological symptoms of brain aging. This book explores all the important aspects of ageing in the present day scenario. It will provide comprehensive knowledge to the readers.