Böcker i Chromatographic Science Series-serien

This book summarizes all the important aspects of multidimensional separations, providing information on gas, liquid and thin-layer chromatography, as well as the techniques and applications of supercritical fluid chromatography in the multidimensional mode.

Covering definitions, concepts, and applications, this title recounts the developments in two types of liquid-liquid chromatography termed countercurrent-high-speed countercurrent chromatography (HSCCC) and centrifugal partition chromatography (CPC).

Presenting a constructive evaluation of the most significant developments in liquid chromatography - mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, this title offers coverage of the technological developments and applications.

Explores the chromatographic methods used for the measurement of drugs, impurities, and excipients in pharmaceutical preparations - such as tablets, ointments, and injectables. This title contains a table listing the chromatographic data of over 1300 drugs and related substances - including sample matrix analyzed and sample handling procedures.

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials.

Explains to chromatographers that gas-liquid chromatography, a development of gas chromatography, is itself just a limited case of gas-liquid-solid chromatography.

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists. This book strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, practices, and case studies from the pharmaceutical industry. Exploring the safety, quality, and regulatory aspects of GTIs, the text explains the how and why of various GTI control tactics and practices, including GTI control examples in drug substance and drug product development processes from large and small pharmaceutical firms in multiple geographical regions.

Focuses on the various aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations and its breakthroughs over the years. This work emphasizes analytical applications of microfluidic technology and offers coverage of micromachining methods, microfluidic operations and injection methods.

Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

Shows how to choose the most effective techniques for assessing the toxicity of chemicals in both food and the environment. This title examines a range of volatile compounds from toxic aldehydes and pesticides to micotoxins and dioxins.

This book covers a range of topics of interest to those involved in the fractionation and characterization of polymeric substances. It deals with problems that are encountered in modern gel permeation chromatography with dual detection when calculating average molecular weights.

This book documents the principles of operation, the advantages and drawbacks, and the potential future of currently available liquid chromatographic detectors. In offering a snapshot of the current technology, it provides clear explanations and possible new horizons for both beginners and experts.

The first book to focus entirely on reactions for analyte detection and characterization,Reaction Detection in Liquid Chromatography depicts off- and on-line, pre- and postcolumnapproaches that have been successfully used for many classes of compounds, bothorganic and inorganic, in high performance liquid chromatography

Covering advancements in separation technique, this book presents concepts including monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, and capillary electromigration techniques. It covers areas of HPLC application, including chiral pharmaceutical, food, and forensic analysis.

Focuses on TLC which applies to the separation, identification, quantification, and isolation of medicinal plant components. This title offers an overview of TLC and phytochemistry. It emphasizes real strategies and procedures for analyzing various types of primary and secondary plant metabolites.

This book covers the principles, kinetics, and applications of derivatization reactions in liquid chromatography. It emphasizes detection-oriented derivatization procedures that can be used to enhance to detectability of a wide variety of solutes using absorbance and fluorescence detection.

This book informs the reader about the practical methods, possibilities, and limits of template chromatography. It shows the various techniques for immobilization of nucleic acids fragments, polynucleotides, and nucleic acids by which the desired separation of materials can be achieved.

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

This book describes new gel permeation chromatography/liquid chromatography applications and techniques that will provide polymer scientists and practitioners with insight into the development of new polymers and plastics and improvement of existing materials.

This book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism. It aids chromatographers, biochemists, biomedical researchers, and chemists by giving information on applications of HPLC technique.

This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

Beginning with classification, nomenclature, and structures, this reference discussesphysicochemical properties of alkaloids relevant to the chromatographic process

Considers three fundamental aspects of molecular interactions important in chromatography, taking care not to duplicate information readily available in other references. Surveys the basic factors involved in complex formation, which governs the retention mechanism and selectivity in either donor or

This book provides a detailed description of technical elements of a microbore column liquid chromatograph suitable for use in trace analysis. It presents examples of analyses, especially from the spheres of biochemistry, pharmacology, and environmental analytical chemistry.

This volume is the first book to give a complete description of the techniques, materials, and instrumentation of column HPLC and its application to essentially all primary and secondary plant metabolites. It describes the techniques and instrumentation of HPLC analysis, such as HPLC/nuclear magnetic resonance spectrometry, HPLC with photodiode array detection, and HPLC chiral analysis. It explores the application of HPLC to primary and secondary plant metabolites and discusses how HPLC is used for analyzing herbal drugs and dietary supplements.

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President's Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

Comprehensively covers the design, construction, and operation of gas chromatography, liquid chromatography, and thin-layer chromatography detectors. This title emphasizes the essential use of common specifications to describe various detectors, allowing easy comparison of their attributes.