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This volume is designed to provide an updated picture of the existing knowledge about the association between steroid enzyme expression/function and the development and/or progression of major human cancers, including classical (breast, prostate) and nonclassical (lung, liver) hormone-related tumors.

At a microscopic level, organisms are ruled by interacting systems of biomolecules. Historically, scientists painstakingly elucidated chains of molecular events using experiments that reveal individual interactions, although they recognized that members of different pathways frequently interact.

Reviews main effects of natural compounds on the different apoptotic signaling pathways Topics covered include: effects of natural compounds on cancer cells, natural compounds as inducers of cell death, and diet in health and disease Part of the Annals of the New York Academy of Sciences series.

This volume features in-depth reviews of the major issues and emerging topics in ecology and conservation biology. The contributors are among the top researchers in the field. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.

Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases.

This volume contains the proceedings of the 5th International Conference on Rickettsiae and Rickettsial Diseases, in which an effort is made to address and clarify issues from clinical, diagnostic, epidemiologic, and molecular perspectives that have remained unsolved in the past.

Oligonucleotides modulate gene-specific expression within cells and can be used to identify genes involved in diseases. Continuing developments in oligonucleotide research have begun to unleash their potential as therapeutic agents.

The recent literature on whole genome sequences provides abundantevidence for the action of natural genetic engineering inevolution. Discoveries about natural genetic engineering havecoincided with rapid progress in our understanding of epigeneticcontrol and RNA-directed chromatin formation.

This volume explores the effects of glucocorticoids on mood and the mechanisms mediating these effects, including aspects of the clinical effects of glucocorticoids in a variety of illnesses and in health, including molecular mechanisms, glucocorticoid resistance and sensitivity, glucocorticoid receptor polymorphisms, and implications for therapy.

With ten million persons afflicted each year, no one is entirely immune to cancer and its devastating effects on individuals and families. But recent advances in the development of cancer vaccines-either as therapeutic agents or as preventative measures-are hopeful indicators of progress in this field.

Advances in biomarker development are revolutionizing the way we study, diagnose and treat disease. However, progress in the development and use of biomarkers for diseases of the central nervous system has been limited by a number of difficulties -- including the inherent barriers associated with studying the brain.

International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia.

This volumes examines the mechanisms that underlie the generationof sensory and motor activity in the functional and dysfunctionalspinal cord: a cutting-edge model system for both basic andtranslational neuroscience.

As anticipated for the series, this year s volume contains adiverse collection of timely reviews on current problems inconservation biology and their scientific, policy, and managementimplications.

This volumes features contributions on the latest advances in thechemistry, biology and clinical applications of the thymosins fromleading scientists and clinicians working in the field.

This volume recognizes the rapidly expanding research linkingaging, age-related diseases, and the delicate balance betweenneurodegeneration and cancer.

The new century brings challenges and opportunities with an agingpopulation and the rise of food prices and health care costs. Scientific advances are changing the way we approach and define thescientific questions about nutrition. We can now develop molecularand genomic approaches to human intervention.

This is the inaugural volume in a series of reviews on the theory,policy, and implementation of sustainability and sustainabledevelopment, with a focus on the economic, social, andenvironmental challenges facing the world today.

This volume features expert, refereed reviews of timely topics ineach of the areas relevant to addiction science and clinicalpractice to aid researchers and practitioners interested inaddictions. Authors from the United States, EU, Asia and elsewhereprovide an international perspective on the problems and practices.

This volume examines various approaches to neuroprotection,including methods for neuroprotection, mechanisms involved inneuroinjury, pharmacologic agents associated withneuroprotection. NOTE: Annals volumes are available for sale as individual booksor as a journal. .

This second volume in The Year in Neurology series focuses onpresent reviews covering novel approaches to our understandingneurological diseases through both basic science and clinicalapproaches.

This volume highlights key presentations from a meeting of international experts from academia, industry and government convened to discuss the scientific and clinical basis for the successes and failures of recombinant cytokines and cytokine antagonists as therapeutic agents, and possible strategies for improving their clinical success.

As part ofthe Annals of the New York Academy of Sciences series, this volumeexamines mechanisms involved in bone development and restructuring,including cellular and mechanical triggers, receptors, andsignalling pathways.

This third installment of The Year in Diabetes and Obesity review series includes reviews with a special focus on metabolic syndrome and health. NOTE: Annals volumes are available for sale as individual books or as a journal.

A recent upsurge of research examining inositol phospholipids (IP) membrane-bound species fundamental to cell signaling continues underscore the role of this pathway in both normal and disease-associated cellular physiology.

The latest volume of "The Year in Evolutionary Biology" series of the Annals features six synthetic reviews and two perspectives.

This volume examines the wide-ranging psychiatric and neurologic consequences of war affecting every level of human organization from the nation state to the molecular. The volume present these consequences from a multitude of perspectives and modes of inquiry; from the intrapsychic to the empirical.

This volume examines the phytoalexin resveratrol and the ongoing studies about its effects on lifespan and health.

The Year in Diabetes and Obesity will fulfill a critical need in by publishing timely, thought-provoking reviews on the molecular, basic, and clinical aspects of diabetes and obesity.

This is the inaugural volume in a new series of reviews. Each annual volume will contain authoritative reviews of developing research topics in antimicrobial therapeutics. Authors will describe how the research being reviewed can be applied to real-world problems.