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Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

Each volume of "Advances in Pharmacology" provides a collection of reviews on contemporary topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. This volume covers biochemistry and molecular biology.

Part of the "Advances in Pharmacology" series, this volume deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states. It covers anesthetics and cardiac function, and addresses disorders of the cardiovascular system and associated diseases. It explains therapeutic and pathophysiological implications.

Each volume in this series provides a collection of reviews on current topics in the field of pharmacology. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

This is an index for the 44 volumes in the "Advances in Pharmacology" series.

Each volume in "Advances in Pharmacology" provides a collection of reviews on current topics in the field. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Includes discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. This book deals with some of the effects of cyclic GMP on other second messengers.

This volume presents reviews on pharmacologic advances. The emphasis is on the molecular bases of drug action, both applied and experimental.

Volume 30 in the "Advances in Pharmacology" series, which offers a collection of reviews on contemporary topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Volumes in this series present recent developments in pharmacology, with emphasis on the molecular basis of drug action, both applied and experimental.

Part of the "Advances in Pharmacology" series, this volume includes reviews on some of the topics in pharmacology, including: multidrug resistance and the MDR1 gene in gene therapy; regulation of calcium channels in epithelial cells; gene therapy and vascular disease; potential therapeutic applications for Heparin; and calcium channel blockers.

Conjugation reactions have long been associated with the detoxification of xenobiotics. This volume features a two-color dust jacket, and summarizes the information on: xenobiotic conjugation; drug toxicity, hypersensitivity, and targeting; glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity; and more.

Neuropsychotherapeutics, Volume 86, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field, with this updated edition including sections on Pharmacotherapy of psychiatric disorders, Allosteric mechanisms for neuropsychopharmacology, Lipid rafts, Rapid-acting antidepressants, mGlu2/3 receptor antagonists, Nitric oxide: antidepressant mechanisms and inflammation, Anxiety disorders, mGlu receptors and schizophrenia, mAChR ligands for schizophrenia and addiction, PDE10 inhibitors, Obsessive-compulsive disorder, Addiction disorders (including eating), Dopamine D1 PAMs as a New Mode for Treatment of Neuropsychiatric Disorders, and more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. Includes the authority and expertise of leading contributors in pharmacologyPresents the latest release in the Advances in Pharmacology series

Presents catecholamine symposium proceedings. This title includes chapters that cover such topics as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters.

Suitable for pharmacologists, immunologists and biochemists alike, this title explores the antiviral agents. It includes chapters that cover such topics as virus entry inhibitors, interferon-free drug combinations, and antiviral agents for HSV.

Explores the state of Alzheimer's disease research and therapeutics. In this title, chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin.

Suitable for pharmacologists, immunologists and biochemists alike, this title explores the state of Alzheimer's disease research and therapeutics. It includes chapters that cover topics such as the role heat shock proteins play in the Alzheimer's Theater, and Gamma-Secretase as a Target for Alzheimer's Disease.

Development of targeted cancer therapies has already shown promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these advances. This book brings together some of foremost basic science and clinical researchers.

Explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. This title also explores advances in structure determination and structure-based drug design as well as concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones.

Offers an overview of the field of purinergic signalling through adenosine and ATP receptors.

Presents a collection of reviews and places emphasis on the molecular basis of drug action, both applied and experimental. This title includes articles written by some of the leading investigators in the field.

Provides a review of the scientific and regulatory perspectives of drug-drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies.